Development and progress of fluorescence imaging technology in diagnosis and treatment of oral cancer

Hongtao XU; Xiaojuan HUANG; Chongyang ZHENG; Zhiyuan ZHANG

doi:10.19401/j.cnki.1007-3639.2023.09.008

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Development and progress of fluorescence imaging technology in diagnosis and treatment of oral cancer

Review | 更新时间：2025-12-31

- Development and progress of fluorescence imaging technology in diagnosis and treatment of oral cancer
- China Oncology Vol. 33, Issue 9, Pages: 874-878(2023)
- 作者机构：
  
  上海交通大学医学院附属第九人民医院口腔颌面头颈肿瘤科，上海交通大学口腔医学院，国家口腔医学中心，国家口腔疾病临床医学研究中心，上海市口腔医学重点实验室，上海市口腔医学研究所，中国医学科学院口腔颌面再生医学创新单元，上海 200011
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2023.09.008
  CLC： R739.85
- Received：01 February 2023，
  
  Revised：2023-05-04，
  
  Published：30 September 2023
- 稿件说明：
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Hongtao XU, Xiaojuan HUANG, Chongyang ZHENG, et al. Development and progress of fluorescence imaging technology in diagnosis and treatment of oral cancer[J]. China Oncology, 2023, 33(9): 874-878.
DOI：

Hongtao XU, Xiaojuan HUANG, Chongyang ZHENG, et al. Development and progress of fluorescence imaging technology in diagnosis and treatment of oral cancer[J]. China Oncology, 2023, 33(9): 874-878. DOI： 10.19401/j.cnki.1007-3639.2023.09.008.

摘要

口腔癌治疗目前面临的主要临床问题是术后复发和转移。如何提高手术切除效率、改善患者预后是实现口腔癌根治的关键。荧光成像技术作为辅助性手段应用于口腔癌的诊断和治疗，能够以非侵入、无辐射的方式提供实时、超高分辨率的影像学资料，达到术前肿瘤识别诊断、术中肿瘤边界确定及术后癌床检查的效果，有助于降低复发率、提高患者生存率和生存质量。本文就应用于口腔癌临床和基础研究的代表性荧光探针及其特点、局限性和应用前景予以综述。

Abstract

The main clinical problems in treatment of oral cancer are tumor recurrence and metastasis after surgery. To improve the efficiency of resection and the prognosis of patients is a key to curing oral cancer. Fluorescence imaging

as an adjuvant in the diagnosis and treatment of oral cancer with no invasion and radiation

can provide real-time and ultrahigh-resolution graphics for preoperative tumor diagnosis

intraoperative tumor margin determination and postoperative tumor bed checking

which can help reduce the recurrent rate

enhance the survival rate and improve the life quality of patients. This article reviewed several typical fluorescent probes and discussed their characteristics

limitations and application prospects in clinic or research for oral cancer.

关键词

Keywords

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