The latest progress of breast cancer treatment at 2023 ESMO

Teng ZHOU; Jian ZHANG

doi:10.19401/j.cnki.1007-3639.2023.11.002

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The latest progress of breast cancer treatment at 2023 ESMO

Specialist' Commentary | 更新时间：2025-12-31

- The latest progress of breast cancer treatment at 2023 ESMO
- China Oncology Vol. 33, Issue 11, Pages: 981-988(2023)
- 作者机构：
  
  复旦大学附属肿瘤医院大内科，复旦大学附属肿瘤医院Ⅰ期临床试验病房，复旦大学上海医学院肿瘤学系，上海 200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2023.11.002
  CLC： R737.9
- Received：10 November 2023，
  
  Revised：2023-11-17，
  
  Published：30 November 2023
- 稿件说明：
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Teng ZHOU, Jian ZHANG. The latest progress of breast cancer treatment at 2023 ESMO[J]. China Oncology, 2023, 33(11): 981-988.
DOI：

Teng ZHOU, Jian ZHANG. The latest progress of breast cancer treatment at 2023 ESMO[J]. China Oncology, 2023, 33(11): 981-988. DOI： 10.19401/j.cnki.1007-3639.2023.11.002.

摘要

在2023年欧洲肿瘤内科学会（European Society of Medical Oncology，ESMO）年会上，多项乳腺癌领域的最新研究成果公布。在早期乳腺癌方面，免疫检查点抑制剂不仅持续证实了在三阴性乳腺癌新辅助治疗中的价值（KEYNOTE-522和NeoTRIP），也显示出其在激素受体+/人表皮生长因子受体2（human epidermal growth factor receptor 2，HER2）-乳腺癌新辅助治疗中的潜在获益（KEYNOTE-756和CheckMate 7FL）；细胞周期蛋白依赖性激酶4/6（cyclin-dependent kinase 4/6，CDK4/6）抑制剂（如monarchE和NATALEE研究所示）也巩固了在激素受体+/HER2-乳腺癌辅助强化治疗中的重要地位。在晚期乳腺癌治疗方面，新的内分泌治疗选择及抗体药物偶联物（如T-DXd和Dato-DXd）为激素受体+/HER2-患者带来治疗新机遇；汇总分析提示T-DXd对HER2+乳腺癌脑转移疗效表现突出；Dato-DXd联合免疫治疗、新靶点抗体药物偶联物HS-20089分别在一线和后线三阴性乳腺癌治疗中产生可喜效果。

Abstract

At 2023 Annual Meeting of European Society of Medical Oncology (ESMO)

Several latest research achievements in the field of breast cancer were announced. For early-stage breast cancer

immune checkpoint inhibitor has not only continued to prove their value in the neoadjuvant treatment of triple-negative breast cancer (KEYNOTE-522 and NeoTRIP)

but also shown their potential benefit in the neoadjuvant therapy of hormone receptor+/human epidermal growth factor receptor 2 (HER2)- breast cancer (KEYNOTE-756 and CheckMate 7FL). Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors (as shown in the MONARCHE and NATALEE studies) have also solidified an important position in the adjuvant intensive treatment of hormone receptor+/HER2- breast cancer. In advanced breast cancer treatment

new endocrine therapy options and antibody-drug conjugate (T-DXd and Dato-DXd) have opened up new therapeutic opportunities for hormone receptor+/HER2- patients. Pooled analyses suggest that T-DXd has demonstrated outstanding efficacy in brain metastases of HER2+ breast cancer. Dato-DXd in combination with immunization and the new targeted antibody-drug conjugate HS-20089 produced promising efficacy in first-line treatment of and post-line triple-negative breast cancer

respectively.

关键词

Keywords

references

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