The latest research progress on P53 and tumor metabolism

Haihui ZHAI; Yuanqi LIU; Congzheng ZHANG; Liping GUAN; Tao HAN

doi:10.19401/j.cnki.1007-3639.2023.11.009

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The latest research progress on P53 and tumor metabolism

Review | 更新时间：2025-12-31

- The latest research progress on P53 and tumor metabolism
- China Oncology Vol. 33, Issue 11, Pages: 1032-1040(2023)
- 作者机构：
  
  1. 新乡医学院健康中原研究院，河南新乡 453003
  2. 新乡医学院基础医学院，河南新乡 453003
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2023.11.009
  CLC： R730.2
- Received：09 August 2023，
  
  Revised：2023-10-17，
  
  Published：30 November 2023
- 稿件说明：
移动端阅览
Haihui ZHAI, Yuanqi LIU, Congzheng ZHANG, et al. The latest research progress on P53 and tumor metabolism[J]. China Oncology, 2023, 33(11): 1032-1040.
DOI：

Haihui ZHAI, Yuanqi LIU, Congzheng ZHANG, et al. The latest research progress on P53 and tumor metabolism[J]. China Oncology, 2023, 33(11): 1032-1040. DOI： 10.19401/j.cnki.1007-3639.2023.11.009.

摘要

由

53编码的P53蛋白是防止细胞癌变所需的关键因子，有广泛而强大的功能。P53在诱导细胞周期停滞、DNA损伤修复、细胞凋亡和衰老等过程中发挥重要作用，且这些功能的丧失不会使P53失去抑癌活性。新陈代谢是生命的基础，代谢异常导致多种疾病如肿瘤的发生，是癌症进展的主要驱动力之一。最近研究发现P53在调节全身代谢中起关键作用。P53介导的细胞代谢调节是控制肿瘤发生、发展的基本机制，有助于抑制肿瘤活性。本文就P53与葡萄糖、脂肪酸、氨基酸和核苷酸代谢的关系进行综述，并梳理肿瘤发展中P53在这些代谢调控中的复杂机制和最新研究进展。

Abstract

P53 is a key factor encoded by the

and it prevents cells from becoming cancerous and has a wide range of powerful functions. p53 is found to play an important role in inducing DNA repair

apoptosis

cell cycle arrest and senescence

and the loss of these functions does not abrogate P53’s tumor suppressive activity. Metabolism is the basis of life

and metabolic abnormalities can lead to a variety of diseases

including tumors

and is one of the main drivers of cancer progression. It has recently been discovered that P53 plays a key role in regulating metabolism. P53-mediated regulation of cell metabolism is a fundamental mechanism controlling cancer occurrence and development and contributes to its tumor suppressive activity. Here

this article reviewed the relationship between P53 and glucose

fatty acid

amino acid and nucleotide metabolism

and discussed the complex mechanism and the latest research progress of P53 in the metabolic regulation in tumor development.

关键词

Keywords

references

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