Research progress on the role of glutamine metabolism-related proteins in tumor metastasis

Xuerou LIU; Yumei YANG; Qian ZHAO; Xiangyu RONG; Wei LIU; Ruijie ZHENG; Jinlong PANG; Xian LI; Shanshan LI

doi:10.19401/j.cnki.1007-3639.2024.01.007

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Research progress on the role of glutamine metabolism-related proteins in tumor metastasis

Review | 更新时间：2025-12-31

- Research progress on the role of glutamine metabolism-related proteins in tumor metastasis
- China Oncology Vol. 34, Issue 1, Pages: 97-103(2024)
- 作者机构：
  
  1. 蚌埠医科大学药学院，安徽蚌埠 233030
  2. 安徽省生化药物工程技术研究中心，安徽蚌埠 233030
- 作者简介：
  
  LI Shanshan.
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2024.01.007
  CLC： R73-37
- Received：26 October 2023，
  
  Revised：2023-12-20，
  
  Published：30 January 2024
- 稿件说明：
移动端阅览
Xuerou LIU, Yumei YANG, Qian ZHAO, et al. Research progress on the role of glutamine metabolism-related proteins in tumor metastasis[J]. China Oncology, 2024, 34(1): 97-103.
DOI：

Xuerou LIU, Yumei YANG, Qian ZHAO, et al. Research progress on the role of glutamine metabolism-related proteins in tumor metastasis[J]. China Oncology, 2024, 34(1): 97-103. DOI： 10.19401/j.cnki.1007-3639.2024.01.007.

摘要

肿瘤转移是导致癌症患者高死亡率的主要原因。谷氨酰胺在肿瘤的恶性进展中发挥重要作用，近年来研究发现，谷氨酰胺与肿瘤转移密切相关，谷氨酰胺作为肿瘤细胞重要的碳源和氮源，不仅影响肿瘤细胞的增殖，还参与调控肿瘤细胞的迁移和侵袭。此外，谷氨酰胺代谢过程中的各种酶及转运体通过不同的信号转导通路参与肿瘤转移过程。本文综述近年来谷氨酰胺在肿瘤转移中作用的研究进展，并梳理有关治疗靶点，以期为临床治疗肿瘤转移提供新的策略。

Abstract

Tumor metastasis is closely related to high mortality rate of cancer. It is well known that glutamine plays an important role in the malignant progression of cancer. Notably

as an important carbon and nitrogen donor

glutamine has been found to be closely related to tumor metastasis in recent years. Glutamine is not only involved in regulating the proliferation of tumor cells

but is also closely related to the migration and invasion of tumor cells. Furthermore

various enzymes along with transporters in the metabolism of glutamine are involved in the process of tumor metastasis through different signaling pathways. This review provided a summary of the role of glutamine in tumor metastasis in recent years and proposed therapeutic targets to provide new strategies for the clinical treatment of tumor metastases.

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Keywords

references

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Targeted therapy and immunotherapy combined with chemotherapy bring effective response to AFP positive colon cancer patients: a case report and literature review

Research status and progress of third-line treatment for metastatic colorectal cancer

Effectiveness and safety analysis of camrelizumab combined with chemotherapy and targeted therapy in patients with recurrent, metastatic, and treatment-naive advanced cervical cancer: a retrospective cohort study

Research status and prospects of treatment for malignant pleural mesothelioma

Related Author

LU Ye

ZHANG Wenxiang

KONG Xiangyi

FANG Yi

WANG Jing

GAO Jidong

LIU Miao

LI Jinze

Related Institution

Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital& Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Department of Pathology, the Fourth Hospital of Hebei Medical University

Department of Gastroenterology, the Fourth Hospital of Hebei Medical University

Department of Oncology, The First Affiliated Hospital of Naval Medical University

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