Survival analysis of 6 737 surgically resected gastric cancer cases in China from a large single institution hospital-based cancer registry database

Jie SHEN; Jiangli WANG; Zezhou WANG; Miao MO; Changming ZHOU; Jing YUAN; Dazhi XU; Ying ZHENG

doi:10.19401/j.cnki.1007-3639.2024.03.004

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Survival analysis of 6 737 surgically resected gastric cancer cases in China from a large single institution hospital-based cancer registry database

Specialist' Article | 更新时间：2025-12-31

- Survival analysis of 6 737 surgically resected gastric cancer cases in China from a large single institution hospital-based cancer registry database
- China Oncology Vol. 34, Issue 3, Pages: 268-277(2024)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院肿瘤预防部，复旦大学上海医学院肿瘤学系，上海 200032
  2. 复旦大学附属肿瘤医院胃外1科，复旦大学上海医学院肿瘤学系，上海 200032
  3. 上海肿瘤疾病人工智能工程技术研究中心，上海 200032
- 作者简介：
- 基金信息：
  
  Three-year action plan for strengthening the construction of the public health system in Shanghai(GWVI-11.2-YQ37);Shanghai Shenkang Hospital Development Center City-Level Hospital Diagnosis and Treatment Technology Promotion and Optimization Management Project(SHDC22022308)
- DOI：10.19401/j.cnki.1007-3639.2024.03.004
  CLC： R735.2
- Received：18 January 2024，
  
  Revised：2024-03-10，
  
  Published：30 March 2024
- 稿件说明：
移动端阅览
Jie SHEN, Jiangli WANG, Zezhou WANG, et al. Survival analysis of 6 737 surgically resected gastric cancer cases in China from a large single institution hospital-based cancer registry database[J]. China Oncology, 2024, 34(3): 268-277.
DOI：

Jie SHEN, Jiangli WANG, Zezhou WANG, et al. Survival analysis of 6 737 surgically resected gastric cancer cases in China from a large single institution hospital-based cancer registry database[J]. China Oncology, 2024, 34(3): 268-277. DOI： 10.19401/j.cnki.1007-3639.2024.03.004.

摘要

背景与目的：

收集以医院登记为基础的6 737例接受手术切除的胃癌患者的随访资料，分析其1、3和5年观察总生存（overall survival，OS）率和无病生存（disease-free survival，DFS）率，为中国的胃癌防控和政策制定提供真实世界研究证据。

方法：

纳入2015年1月1日—2020年12月31日在复旦大学附属肿瘤医院接受手术治疗的胃癌患者共6 737例，通过查阅患者病史了解患者的临床信息，并通过复诊病史、电话随访和死因数据链接等方式收集患者的生存随访资料，随访统计时间截至2023年11月30日。采用Kaplan-Meier法估计患者1、3和5年OS率和DFS率，并在不同年龄组、性别、治疗时期、肿瘤分期及病理学特征等亚组中分别描述。

结果：

接受手术切除的胃癌患者经中位50.99个月随访后，5年OS率和Ⅰ ~ Ⅲ期患者5年DFS率分别为70.37%和69.46%。Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期胃癌患者的5年OS率分别为94.32%、82.56%、51.01%和23.97%。不同年龄、部位、大体分型、Borrmann分型和Lauren分型的患者生存有显著差异。

结论：

肿瘤分期是影响胃癌患者生存的重要因素，应加强人群（尤其是高危人群）胃癌的筛查和早诊早治，进一步改善患者的生存。

Abstract

Background and purpose:

Follow-up data of 6 737 patients undergoing surgery for gastric cancer were collected based on hospital registration

and the 1-

3- and 5-years observed overall survival (OS) rates and disease-free survival (DFS) rates were analyzed to provide real-world research evidence for the prevention and control of gastric cancer and policy making in China.

Methods:

A total of 6 737 gastric cancer patients who underwent surgical treatment at Fudan University Shanghai Cancer center from 2015 to 2020 were included in this study. Clinical information and the follow-up endpoint data were collected through medical records review

telephone visits and death registry data linkage. The last follow-up date was November 30

2023

. Kaplan-Meier method was applied in evaluating the 1-

3- and 5-year OS rate and DFS rate

and survival data were described by different subgroups including age group

gender

treatment period

tumor staging

and pathological characteristics.

Results:

With a median follow-up time of 50.99 months

the 5-year OS rate of surgically resected gastric cancer patients was 70.37%

and 5-year DFS rate in Ⅰ-Ⅲ stage cases was 69.46%. The 5-year OS rates of stage Ⅰ

Ⅱ

Ⅲ and Ⅳ were 94.32%

82.56%

51.01% and 23.97%

respectively. The differences in survival among patients with different age

tumor location

gross classification

Borrmann classification and Lauren classification were significant.

Conclusion:

Staging is an important factor directly affecting the survival of gastric cancer patients. Screening and early diagnosis and treatment in large population

especially high-risk group

should be strengthened to further improve the patients’ survival.

关键词

Keywords

references

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