Progress in treatment of gynecological cancer in 2023

Zheng FENG; Qinhao GUO; Jun ZHU; Xiaohua WU; Hao WEN

doi:10.19401/j.cnki.1007-3639.2024.04.002

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Progress in treatment of gynecological cancer in 2023

Specialist' Commentary | 更新时间：2025-12-31

- Progress in treatment of gynecological cancer in 2023
- China Oncology Vol. 34, Issue 4, Pages: 340-360(2024)
- 作者机构：
  
  复旦大学附属肿瘤医院妇瘤科，复旦大学上海医学院肿瘤学系，上海 200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2024.04.002
  CLC： R737.3
- Received：12 March 2024，
  
  Revised：2024-04-06，
  
  Published：30 April 2024
- 稿件说明：
移动端阅览
Zheng FENG, Qinhao GUO, Jun ZHU, et al. Progress in treatment of gynecological cancer in 2023[J]. China Oncology, 2024, 34(4): 340-360.
DOI：

Zheng FENG, Qinhao GUO, Jun ZHU, et al. Progress in treatment of gynecological cancer in 2023[J]. China Oncology, 2024, 34(4): 340-360. DOI： 10.19401/j.cnki.1007-3639.2024.04.002.

摘要

对比中国与全球情况可知，中国癌症发病率与世界平均水平接近，但死亡率与全球平均水平有差异。中国妇科恶性肿瘤负担日益加重，城乡差异较大，地区分布不均衡，癌症防控形势严峻。近年来，新技术、新药物[如免疫检查点抑制剂（immune checkpoint inhibitor，ICI）、抗体-药物偶联物（antibody-drug conjugate，ADC）等]陆续进入临床，为妇科恶性肿瘤的治疗带来新希望。本文对2023年度妇科恶性肿瘤的重大研究进展进行梳理，其中，在宫颈癌治疗方面，本文回顾了标准治疗模式革新、晚期复发转移性宫颈癌后线治疗的相关进展（ENGOT-cx11/GOG-3047/KEYNOTE-A18、KEYNOTE-826研究等）；在卵巢癌治疗方面，本文总结了PARP抑制剂及免疫治疗、新诊断卵巢癌一线治疗、复发性卵巢癌治疗的最新进展（FLAMES、ANITA/ENGOT-Ov41/GEICO 69-O、NRG-GY004研究等）；而在子宫内膜癌治疗方面，本文按照局部晚期子宫内膜癌治疗（GOG 258、Lunchbox研究等）、晚期/复发转移性子宫内膜癌治疗方面的进展（如ENGOT-EN6-NSGO/GOG-3031/RUBY研究等）进行综述，并对后线靶向治疗和免疫治疗探索进行总结（如KEYNOTE-775、ADAGIO等研究）。本文从上述方面对妇科肿瘤2023年度的进展进行述评，旨在为临床实践及临床研究的开展提供参考。

Abstract

Compared with the global situation

it can be found that the cancer incidence in China is close to the world average level

but the mortality rate has difference compared with the global average level. The burden of gynecological cancers in China is increasing

with large differences between urban and rural areas and uneven regional distribution. Therefore

the situation of cancer prevention and control is still challenging. In recent years

new technologies and drugs

such as immune checkpoint inhibitors (ICIs) and antibody-drug conjugate (ADC)

have been introduced into clinical practice

bringing new hope for the treatment of gynecological cancers. This article reviewed the major research progress of gynecological cancers in 2023. Among them

in terms of the progress of treatment for cervical cancer

we reviewed the innovation of standard treatment mode and the related progress of post-line treatment for advanced recurrent and metastatic cervical cancer (clinical research such as ENGOT-cx11/GOG-3047/KEYNOTE-A18

KEYNOTE-826). In terms of treatment for ovarian cancer

this review summarized the latest progress of PARP inhibitors

immunotherapy

first-line treatment of newly diagnosed ovarian cancer and treatment of recurrent ovarian cancer (FLAMES

ANITA/ENGOT-Ov41/GEICO 69-O

NRG-GY004

etc.). In terms of treatment for endometrial cancer

this study reviewed the progress in the treatment of locally advanced endometrial cancer (GOG 258

Lunchbox clinical research

etc.) and advanced/recurrent metastatic endometrial cancer (ENGOT-EN6-NSGO/GOG-3031/RUBY research

etc.)

and summarized the exploration of back-line targeted immunotherapy (such as KEYNOTE-775

ADAGIO and other clinical studies). This study combed the progress of gynecological tumors in 2023 from the above aspects

aiming at providing reference for clinical practice and clinical research.

关键词

Keywords

references

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郭勤浩 , 余敏 , 吴小华 . 2022年度妇科肿瘤诊治进展 [J ] . 中国癌症杂志 , 2023 , 33 ( 1 ): 14 - 24 . DOI: 10.19401/j.cnki.1007-3639.2023.01.002 http://doi.org/10.19401/j.cnki.1007-3639.2023.01.002

GUO Qinhao , YU Min , WU Xiaohua . Progress in diagnosis and treatment of gynecological tumors in 2022 [J ] . China Oncology , 2023 , 33 ( 1 ): 14 - 24 . DOI: 10.19401/j.cnki.1007-3639.2023.01.002 http://doi.org/10.19401/j.cnki.1007-3639.2023.01.002

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