Effect of bevacizumab assisted PD-1 inhibitor on serum miR-20a-5p and miR-515-3p in the treatment of gastric cancer

Fei WANG; Pei LIU; Nan HU

doi:10.19401/j.cnki.1007-3639.2024.05.006

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Effect of bevacizumab assisted PD-1 inhibitor on serum miR-20a-5p and miR-515-3p in the treatment of gastric cancer

Article | 更新时间：2025-12-31

- Effect of bevacizumab assisted PD-1 inhibitor on serum miR-20a-5p and miR-515-3p in the treatment of gastric cancer
- China Oncology Vol. 34, Issue 5, Pages: 493-500(2024)
- 作者机构：
  
  南京医科大学第四附属医院肿瘤科，江苏南京 210000
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2024.05.006
  CLC： R735.2
- Received：12 October 2023，
  
  Revised：2024-03-01，
  
  Published：30 May 2024
- 稿件说明：
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Fei WANG, Pei LIU, Nan HU. Effect of bevacizumab assisted PD-1 inhibitor on serum miR-20a-5p and miR-515-3p in the treatment of gastric cancer[J]. China Oncology, 2024, 34(5): 493-500.
DOI：

Fei WANG, Pei LIU, Nan HU. Effect of bevacizumab assisted PD-1 inhibitor on serum miR-20a-5p and miR-515-3p in the treatment of gastric cancer[J]. China Oncology, 2024, 34(5): 493-500. DOI： 10.19401/j.cnki.1007-3639.2024.05.006.

摘要

背景与目的：

二线化疗方案治疗胃癌疗效欠佳，贝伐珠单抗属于抗血管生成分子靶向抗癌药物，信迪利单抗是一种国产的程序性死亡蛋白-1（programmed death-1，PD-1）抑制剂，两者结合是临床治疗胃癌的新方向。本研究旨在探究贝伐珠单抗辅助PD-1抑制剂治疗胃癌对血清miR-20a-5p和miR-515-3p的影响。

方法：

选取2019年1月—2021年7月于南京医科大学第四附属医院就诊的84例胃癌患者进行回顾性研究，根据治疗方案的不同将其分为观察组和对照组（每组各42例），对照组给予二线化疗方案治疗，观察组在对照组基础上给予贝伐珠单抗联合PD-1抑制剂（信迪利单抗）治疗，比较两组的客观缓解率（objective response rate，ORR）、疾病控制率（disease control rate，DCR）、血清肿瘤标志物、免疫功能指标、血清miR-20a-5p、miR-515-3p及不良反应总发生率。本研究已通过南京医科大学第四附属医院伦理委员会的伦理审批（批件号：20230531--K061）。

结果：

观察组的ORR（69.05%）和DCR（85.71%）均高于对照组（40.48%、64.29%）。观察组治疗后的血清糖类抗原12-5（carbohydrate antigen 12-5，CA12-5）、癌胚抗原（carcinoembryonic antigen，CEA）及细胞角蛋白19片段抗原21-1（cytokerantin-19-fragment antigen 21-1，CYFRA21-1）水平均低于对照组。观察组治疗后的CD4

T淋巴细胞、CD4

/CD8

淋巴细胞比值均高于对照组，CD8

T淋巴细胞低于对照组，差异均有统计学意义（

0.05）。观察组治疗后的血清miR-20a-5p、miR-515-3p水平均低于对照组，差异有统计学意义（

0.05）。观察组（28.57%）的不良反应总发生率与对照组（38.10%）相比，差异无统计学意义（

0.05）。

结论：

贝伐珠单抗辅助信迪利单抗可有效地提高胃癌治疗效率，改善免疫功能，降低血清miR-20a-5p、miR-515-3p及肿瘤标志物表达量，且不会增加不良反应，效果显著。

Abstract

Background and purpose:

Second-line chemotherapy is not effective in the treatment of gastric cancer. Bevacizumab is a molecularly targeted anticancer drug

and sindilizumab is a domestic programmed death-1 (PD-1) inhibitor. The combination of the two is a new direction for clinical treatment of gastric cancer. This study aimed to analyze the effects of bevacizumab assisted PD-1 inhibitor in the treatment of gastric cancer on serum miR-20a-5p and miR-515-3p.

Methods:

A retrospective study was conducted on 84 patients with gastric cancer treated in the Fourth Affiliated Hospital of Nanjing Medical University from January 2019 to July 2021

and they were divided into the observation group and the control group with 42 cases each according to different treatment plans. The control group was given second-line chemotherapy

and the observation group was given bevacizumab combined with PD-1 inhibitor (sindilizumab) on the basis of the control group. objective response rate (ORR)

disease control rate (DCR)

serum tumor markers

immune function indexes

serum miR-20a-5p and miR-515-3p levels and total incidence of toxic and side effects were compared between the two groups. This study has been approved by the Ethics Committee of the Fourth Affiliated Hospital of Nanjing Medical University (approval number: 20230531--K061).

Results:

The ORR (69.05%) and DCR (85.71%) of the observation group were higher than those of the control group (40.48% and 64.29%)

and the difference was statistically significant (

0.05). After treatment

serum carbohydrate antigen 1

2-5 (CA12-5)

carcinoembryonic antigen (CEA) and cytokerantin-19-fragment antigen 21-1 (CYFRA21-1) levels were lower in observation group than in control group (

0.05). CD4

T lymphocyte and CD4

/CD8

T lymphocyte ratio were higher in observation group than in control group after treatment (

0.05)

and CD8

T lymphocyte was lower in observation group than in control group after treatment (

0.05). After treatment

the serum levels of miR-20a-5p and miR-515-3p were lower in the observation group than in the control group (

0.05). There was no significant difference in total incidence of adverse effects between the observation group (28.57%) and the control group (38.10%) (

0.05).

Conclusion:

Bevacizumab assisted sindilizumab can effectively improve the treatment efficiency of gastric cancer

improve immune function

and reduce the expression levels of serum miR-20a-5p

miR-515-3p and tumor markers

without increasing toxic and side effects.

关键词

Keywords

references

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