New advances in basic research, clinical diagnosis and treatment of pancreatic cancer in 2024

Ting WANG; Yi QIN; Xiaowu XU; Xianjun YU

doi:10.19401/j.cnki.1007-3639.2025.01.001

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New advances in basic research, clinical diagnosis and treatment of pancreatic cancer in 2024

Specialist' Commentary | 更新时间：2025-12-31

- New advances in basic research, clinical diagnosis and treatment of pancreatic cancer in 2024
- China Oncology Vol. 35, Issue 1, Pages: 1-11(2025)
- 作者机构：
  
  复旦大学附属肿瘤医院胰腺外科，复旦大学上海医学院肿瘤学系，上海市胰腺肿瘤研究所，上海市胰腺肿瘤精准诊疗重点实验室，复旦大学胰腺肿瘤研究所，上海 200032
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China(U21A20374);National Natural Science Foundation of China(82373006);National Natural Science Foundation of China(82172948);National Natural Science Foundation of China(82141129);National Natural Science Foundation of China(82173281);Shanghai Municipal Science and Technology Major Project(21JC1401500)
- DOI：10.19401/j.cnki.1007-3639.2025.01.001
  CLC： R735.9
- Received：31 December 2024，
  
  Revised：2025-01-21，
  
  Published：30 January 2025
- 稿件说明：
移动端阅览
Ting WANG, Yi QIN, Xiaowu XU, et al. New advances in basic research, clinical diagnosis and treatment of pancreatic cancer in 2024[J]. China Oncology, 2025, 35(1): 1-11.
DOI：

Ting WANG, Yi QIN, Xiaowu XU, et al. New advances in basic research, clinical diagnosis and treatment of pancreatic cancer in 2024[J]. China Oncology, 2025, 35(1): 1-11. DOI： 10.19401/j.cnki.1007-3639.2025.01.001.

摘要

胰腺癌是一种恶性程度极高的恶性肿瘤，其发病率自2000年以来呈缓慢增长趋势。尽管诊疗水平的提升促使胰腺癌患者的5年生存率相较于50年前有了一定提高，但仍是预后不容乐观的恶性肿瘤之一。步入2024年，胰腺癌早期筛查策略、疾病机制探索、临床诊疗方案等研究领域取得了诸多进展，并显示出良好的临床应用前景。早期筛查方面，人工智能（artificial intelligence，AI）技术赋能胰腺癌早诊、早筛，使临床诊疗踏上新台阶；此外，液体活检等技术的准确率提升，为胰腺癌早筛提供了新方向。疾病发病机制研究方面，3D基因组映射技术揭示了胰腺导管上皮内瘤变（pancreatic intraepithelial neoplasm，PanIN）的多克隆起源和遗传异质性。基础研究方面，模拟胰腺癌独特结构特征的分支器官模拟系统为胰腺癌体外研究提供了新模型；肿瘤重要代谢物乳酸将胰腺癌代谢微环境与表观遗传学改变联系在一起，揭示了潜在治疗靶点；组蛋白H3K36三甲基转移酶SETD2缺陷导致胰腺癌内源性表观遗传失调，并促进线粒体氧化磷酸化（oxidative phosphorylation，OXPHOS）和肿瘤进展；基质细胞与癌细胞间信号分子血小板衍生生长因子受体（platelet-derived growth factor receptor，PDGFR）轴形成双向分泌回路，或能成为治疗新靶点；嵌合抗原受体巨噬细胞（chimeric antigen receptor macrophage，CAR-M）靶向c-MET的疗法展现出与化疗药物协同增效的潜力；胰腺癌微环境中的巨噬细胞通过CCL5/TRAF6/核因子-κB（nuclear factor-κB，NF-κB）通路促进胰腺癌恶病质进展，表明巨噬细胞有望成为预测及干预胰腺癌恶病质发生、发展的有效靶点。诊疗方面，新辅助化疗后手术可改善可切除与交界可切除患者的总生存（overall survival，OS），但仍需进一步优化新辅助化疗方案；首个临床有效的KRAS

G12D

靶向药物已见报道，广谱

KRAS

突变体抑制剂研究不断涌现；通过糖酵解相关评分（glycolysis-related scores，GRS）进行患者分层能够进一步指导治疗方案选择；“智能外泌体”（Exo

Smart

）通过增强细胞摄取能力协助提高化疗效果；免疫治疗联合化疗临床试验的实施，有望协同提高胰腺癌疗效；派安普利单抗和安罗替尼联合白蛋白结合型紫杉醇/吉西他滨（PAAG）在一线转移性胰腺癌（metastatic pancreatic cancer，mPC）患者中显示出较好的疗效和安全性；靶向

KRAS

突变编码新抗原的癌症疫苗ELI-002 2P能够诱导抗肿瘤免疫反应；溶瘤腺病毒疗法能够协同化疗

药物提高晚期胰腺导管腺癌患者的疗效。本文就2024年度胰腺癌基础研究和诊疗领域的最新重大进展进行综述。

Abstract

Pancreatic cancer is a highly malignant tumor

and its incidence rate has been slowly increasing since 2000. Although the improvement of diagnosis and treatment has led to an increase in the five-year survival rate of pancreatic cancer compared to 50 years ago

it remains one of the discouraging tumor diseases regarding its prognosis. In 2024

many achievements were made in the research of early screening

disease mechanism

clinical diagnosis and treatment of pancreatic cancer

showing a good prospect for clinical application. In early screening

artificial intelligence (AI) technology has empowered early diagnosis and screening of pancreatic cancer

pushing clinical diagnosis and treatment to a new level. Additionally

improvements in the accuracy of technologies such as liquid biopsy have provided new directions for early screening of pancreatic cancer. In terms of research on disease pathogenesis

3D genome mapping technology has revealed the polyclonal origin and genetic heterogeneity of pancreatic intraepithelial neoplasm (PanIN). In basic research

a branched organ simulation system that mimics the unique structural characteristics of pancreatic cancer provides a new model for

in vitro

studies of pancreatic cancer. Lactate

an important tumor metabolite

links the metabolic microenvironment of pancreatic cancer with epigenetic changes

revealing potential therapeutic targets. Defects in the histone H3K36 trimethyltransferase SETD2 contribute to endogenous epigenetic dysregulation in pancreatic cancer and promote mitochondrial oxidative phosphorylation (OXPHOS) and tumor progression. The platelet-derived growth factor receptor (PDGFR) axis

which facilitates communication between stromal cells and cancer cells

forms a bidirectional secretory circuit and may become a new therapeutic target. Chimeric antigen receptor macrophage (CAR-M) therapy targeting

the tyrosine kinase receptor c-MET demonstrates potential for synergistic enhancement with chemotherapy drugs. Macrophages in the pancreatic cancer microenvironment promote the development of pancreatic cancer cachexia through the CCL5/TRAF6/nuclear factor-κB (NF-κB) pathway

suggesting that macrophages could be an effective target for predicting and intervening in the development of pancreatic cancer cachexia. In terms of advancements in diagnosis and treatment

surgery following neoadjuvant chemotherapy can improve overall survival (OS) in resectable and borderline resectable patients

but further optimization of neoadjuvant chemotherapy protocols is needed. The first clinically effective KRAS

G12D

-targeted drug has been reported

and research on inhibitors of a wide range of KRAS mutants is continually emerging. Patient stratification based on glycolysis-related scores (GRS) can further guide the selection of treatment protocols. “Intelligent exosomes” (Exo

Smart

) enhance cellular uptake capacity to assist in improving chemotherapy efficacy. The implementation of clinical trials combining immunotherapy with chemotherapy is expected to synergistically improve the efficacy of pancreatic cancer treatment. Pembrolizumab and anlotinib combined with albumin-bound paclitaxel/gemcitabine (PAAG) have shown great efficacy and safety in first-line treatment of metastatic pancreatic cancer (mPC) patients. The cancer vaccine ELI-002 2P

which targets

KRAS

mutation-encoded neoantigens

can induce an antitumor immune response. Oncolytic adenovirus therapy can synergistically improve the efficacy of treatment in advanced pancreatic ductal adenocarcinoma patients when combined with chemotherapy. This article reviewed the latest major progress in the field of basic research and diagnosis and treatment of pancreatic cancer in 2024.

关键词

Keywords

references

SIEGEL R L , GIAQUINTO A N , JEMAL A . Cancer statistics, 2024 [J ] . CA Cancer J Clin , 2024 , 74 ( 1 ): 12 - 49 .

BRAY F , LAVERSANNE M , SUNG H , et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J ] . CA Cancer J Clin , 2024 , 74 ( 3 ): 229 - 263 .

WU Y , HE S , CAO M , et al. Comparative analysis of cancer statistics in China and the United States in 2024 [J ] . Chin Med J (Engl) , 2024 , 137 ( 24 ): 3093 - 3100 .

KAMISAWA T , WOOD L D , ITOI T , et al. Pancreatic cancer [J ] . Lancet , 2016 , 388 ( 10039 ): 73 - 85 . DOI: 10.1016/S0140-6736(16)00141-0 http://doi.org/10.1016/S0140-6736(16)00141-0

MAZER B L , LEE J W , ROBERTS N J , et al. Screening for pancreatic cancer has the potential to save lives, but is it practical? [J ] . Expert Rev Gastroenterol Hepatol , 2023 , 17 ( 6 ): 555 - 574 .

PREVENTIVE SERVICES TASK FORCE U S , OWENS D K , DAVIDSON K W , et al. Screening for pancreatic cancer: US preventive services task force reaffirmation recommendation statement [J ] . JAMA , 2019 , 322 ( 5 ): 438 - 444 . DOI: 10.1001/jama.2019.10232 http://doi.org/10.1001/jama.2019.10232

DBOUK M , KATONA B W , BRAND R E , et al. The multicenter cancer of pancreas screening study: impact on stage and survival [J ] . J Clin Oncol , 2022 , 40 ( 28 ): 3257 - 3266 .

VASEN H , IBRAHIM I , PONCE C G , et al. Benefit of surveillance for pancreatic cancer in high-risk individuals: outcome of long-term prospective follow-up studies from three European expert centers [J ] . J Clin Oncol , 2016 , 34 ( 17 ): 2010 - 2019 . DOI: 10.1200/JCO.2015.64.0730 http://doi.org/10.1200/JCO.2015.64.0730

CANTO M I , ALMARIO J A , SCHULICK R D , et al. Risk of neoplastic progression in individuals at high risk for pancreatic cancer undergoing long-term surveillance [J ] . Gastroenterology , 2018 , 155 ( 3 ): 740 - 751 .e2. DOI: S0016-5085(18)34568-2 http://doi.org/S0016-5085(18)34568-2

CALDERWOOD A H , SAWHNEY M S , THOSANI N C , et al. American Society for Gastrointestinal Endoscopy guideline on screening for pancreatic cancer in individuals with genetic susceptibility: methodology and review of evidence [J ] . Gastrointest Endosc , 2022 , 95 ( 5 ): 827 - 854 .e3. DOI: 10.1016/j.gie.2021.12.002 http://doi.org/10.1016/j.gie.2021.12.002

BLACKFORD A L , CANTO M I , DBOUK M , et al. Pancreatic cancer surveillance and survival of high-risk individuals [J ] . JAMA Oncol , 2024 , 10 ( 8 ): 1087 - 1096 . DOI: 10.1001/jamaoncol.2024.1930 http://doi.org/10.1001/jamaoncol.2024.1930

RAMÍREZ-MALDONADO E , LÓPEZ GORDO S , MAJOR BRANCO R P , et al. Clinical application of liquid biopsy in pancreatic cancer: a narrative review [J ] . Int J Mol Sci , 2024 , 25 ( 3 ): 1640.

LAN B , ZENG S Y , GRÜTZMANN R , et al. The role of exosomes in pancreatic cancer [J ] . Int J Mol Sci , 2019 , 20 ( 18 ): 4332.

LUO G P , LIU C , GUO M , et al. Potential biomarkers in lewis negative patients with pancreatic cancer [J ] . Ann Surg , 2017 , 265 ( 4 ): 800 - 805 . DOI: 10.1097/SLA.0000000000001741 http://doi.org/10.1097/SLA.0000000000001741

FAHRMANN J F , MAX SCHMIDT C , MAO X Y , et al. Lead-time trajectory of CA19-9 as an anchor marker for pancreatic cancer early detection [J ] . Gastroenterology , 2021 , 160 ( 4 ): 1373 - 1383 .e6. DOI: 10.1053/j.gastro.2020.11.052 http://doi.org/10.1053/j.gastro.2020.11.052

RAHBARGHAZI R , JABBARI N , SANI N A , et al. Tumor-derived extracellular vesicles: reliable tools for cancer diagnosis and clinical applications [J ] . Cell Commun Signal , 2019 , 17 ( 1 ): 73.

LI H , CHIANG C L , KWAK K J , et al. Extracellular vesicular analysis of glypican 1 mRNA and protein for pancreatic cancer diagnosis and prognosis [J ] . Adv Sci (Weinh) , 2024 , 11 ( 11 ): e23 06373.

LIU M C , OXNARD G R , KLEIN E A , et al. Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA [J ] . Ann Oncol , 2020 , 31 ( 6 ): 745 - 759 . DOI: 10.1016/j.annonc.2020.02.011 http://doi.org/10.1016/j.annonc.2020.02.011

DOR Y , CEDAR H . Principles of DNA methylation and their implications for biology and medicine [J ] . Lancet , 2018 , 392 ( 10149 ): 777 - 786 . DOI: S0140-6736(18)31268-6 http://doi.org/S0140-6736(18)31268-6

SCHRAG D , BEER T M , MCDONNELL C H 3rd , et al. Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study [J ] . Lancet , 2023 , 402 ( 10409 ): 1251 - 1260 . DOI: 10.1016/S0140-6736(23)01700-2 http://doi.org/10.1016/S0140-6736(23)01700-2

中国抗癌协会肿瘤标志专业委员会 . 肿瘤DNA甲基化标志物检测及临床应用专家共识(2024版) [J ] . 中国癌症防治杂志 , 2024 , 16 ( 2 ): 129 - 142 .

Committee of Tumor Biomarker of China Anti-Cancer Association . Expert consensus on the detection and clinical application of tumor DNA methylation biomarkers (2024 edition) [J ] . Chin J of Oncol Prev and Treat , 2024 , 16 ( 2 ): 129 - 142 .

BEN-AMI R , WANG Q L , ZHANG J M , et al. Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer [J ] . Gut , 2024 , 73 ( 4 ): 639 - 648 .

CAO K , XIA Y D , YAO J W , et al. Large-scale pancreatic cancer detection via non-contrast CT and deep learning [J ] . Nat Med , 2023 , 29 ( 12 ): 3033 - 3043 .

MAITRA A , TOPOL E J . Early detection of pancreatic cancer and AI risk partitioning [J ] . Lancet , 2024 , 403 ( 10435 ): 1438.

DAHER H , PUNCHAYIL S A , ISMAIL A A E , et al. Advancements in pancreatic cancer detection: integrating biomarkers, imaging technologies, and machine learning for early diagnosis [J ] . Cureus , 2024 , 16 ( 3 ): e56583.

BRAXTON A M , KIEMEN A L , GRAHN M P , et al. 3D genomic mapping reveals multifocality of human pancreatic precancers [J ] . Nature , 2024 , 629 ( 8012 ): 679 - 687 .

DREYER S B , UPSTILL-GODDARD R , LEGRINI A , et al. Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence [J ] . Gastroenterology , 2022 , 162 ( 1 ): 320 - 324 .e4.

PUNEKAR S R , VELCHETI V , NEEL B G , et al. The current state of the art and future trends in RAS-targeted cancer therapies [J ] . Nat Rev Clin Oncol , 2022 , 19 ( 10 ): 637 - 655 . DOI: 10.1038/s41571-022-00671-9 http://doi.org/10.1038/s41571-022-00671-9

LUO J . KRAS mutation in pancreatic cancer [J ] . Semin Oncol , 2021 , 48 ( 1 ): 10 - 18 . DOI: 10.1053/j.seminoncol.2021.02.003 http://doi.org/10.1053/j.seminoncol.2021.02.003

MCINTYRE C A , GRIMONT A , PARK J , et al. Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer [J ] . Cancer Cell , 2024 , 42 ( 9 ): 1614 - 1629 .e5.

MAHADEVAN K K , MCANDREWS K M , LEBLEU V S , et al. KRAS G12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8 + T cells [J ] . Cancer Cell , 2023 , 41 ( 9 ): 1606 - 1620 .e8.

Single-agent divarasib (GDC-6036) in solid tumors with a KRAS G12C mutation-PubMed [J/OL ] . [ 2024-12-19 ] . https://pubmed.ncbi.nlm.nih.gov/37611121/ https://pubmed.ncbi.nlm.nih.gov/37611121/ https://pubmed.ncbi.nlm.nih.gov/37611121/.

STRICKLER J H , SATAKE H , GEORGE T J , et al. Sotorasib in KRAS advanced pancreatic cancer [J ] . N Engl J Med , 2023 , 388 ( 1 ): 33 - 43 .

ZHENG Q H , ZHANG Z Y , GUILEY K Z , et al. Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D [J ] . Nat Chem Biol , 2024 , 20 : 1114 - 1122 . DOI: 10.1038/s41589-024-01565-w http://doi.org/10.1038/s41589-024-01565-w

HALLIN J , BOWCUT V , CALINISAN A , et al. Anti-tumor efficacy of a potent and selective non-covalent KRAS G12D inhibitor [J ] . Nat Med , 2022 , 28 ( 10 ): 2171 - 2182 .

WANG X L , ALLEN S , BLAKE J F , et al. Identification of MRTX1133, a noncovalent, potent, and selective KRAS G12D inhibitor [J ] . J Med Chem , 2022 , 65 ( 4 ): 3123 - 3133 .

WEI D Y , WANG L , ZUO X S , et al. A small molecule with big impact: MRTX1133 targets the KRAS G12D mutation in pancreatic cancer [J ] . Clin Cancer Res , 2024 , 30 ( 4 ): 655 - 662 .

ZHOU C C , LI C Y , LUO L B , et al. Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer [J ] . Cancer Cell , 2024 , 42 ( 7 ): 1286 - 1300 .e8.

KIM D , HERDEIS L , RUDOLPH D , et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth [J ] . Nature , 2023 , 619 ( 7968 ): 160 - 166 .

WASKO U N , JIANG J J , DALTON T C , et al. Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer [J ] . Nature , 2024 , 629 ( 8013 ): 927 - 936 .

JIANG J J , JIANG L Y , MALDONATO B J , et al. Translational and therapeutic evaluation of RAS-GTP inhibition by RMC-6236 in RAS-driven cancers [J ] . Cancer Discov , 2024 , 14 ( 6 ): 994 - 1017 .

EVAN T , WANG V M , BEHRENS A . The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma [J ] . Oncogene , 2022 , 41 ( 42 ): 4686 - 4695 . DOI: 10.1038/s41388-022-02448-x http://doi.org/10.1038/s41388-022-02448-x

COLLISSON E A , BAILEY P , CHANG D K , et al. Molecular subtypes of pancreatic cancer [J ] . Nat Rev Gastroenterol Hepatol , 2019 , 16 ( 4 ): 207 - 220 . DOI: 10.1038/s41575-019-0109-y http://doi.org/10.1038/s41575-019-0109-y

PAPARGYRIOU A , NAJAJREH M , COOK D P , et al. Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma [J ] . Nat Biomed Eng , 2024 .

CHANG Y , CHEN Q , LI H , et al. The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells [J ] . Dev Cell , 2024 , 59 ( 10 ): 1317 - 1332 .e5.

YANG J S , REN B , YANG G , et al. The enhancement of glycolysis regulates pancreatic cancer metastasis [J ] . Cell Mol Life Sci , 2020 , 77 ( 2 ): 305 - 321 . DOI: 10.1007/s00018-019-03278-z http://doi.org/10.1007/s00018-019-03278-z

EL KAOUTARI A , FRAUNHOFFER N A , AUDEBERT S , et al. Pancreatic ductal adenocarcinoma ubiquitination profiling reveals specific prognostic and theranostic markers [J ] . EBioMedicine , 2023 , 92 : 104634 .

LIN J , LIU G , CHEN L D , et al. Targeting lactate-related cell cycle activities for cancer therapy [J ] . Semin Cancer Biol , 2022 , 86 ( Pt 3 ): 1231 - 1243 . DOI: 10.1016/j.semcancer.2022.10.009 http://doi.org/10.1016/j.semcancer.2022.10.009

LI H D , SUN L C , GAO P , et al. Lactylation in cancer: current understanding and challenges [J ] . Cancer Cell , 2024 , 42 ( 11 ): 1803 - 1807 .

LI F , SI W Z , XIA L , et al. Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma [J ] . Mol Cancer , 2024 , 23 ( 1 ): 90.

NIU N N , SHEN X Q , WANG Z , et al. Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer [J ] . Cancer Cell , 2024 , 42 ( 5 ): 869 - 884 .e9. DOI: 10.1016/j.ccell.2024.03.005 http://doi.org/10.1016/j.ccell.2024.03.005

HO W J , JAFFEE E M , ZHENG L . The tumour microenvironment in pancreatic cancer: clinical challenges and opportunities [J ] . Nat Rev Clin Oncol , 2020 , 17 : 527 - 540 .

HUANG P W , GAO W N , FU C Y , et al. Clinical functional proteomics of intercellular signalling in pancreatic cancer [J ] . Nature , 2025 , 637 : 726 - 735 .

UPADHRASTA S , ZHENG L . Strategies in developing immunotherapy for pancreatic cancer: recognizing and correcting multiple immune “defects” in the tumor microenvironment [J ] . J Clin Med , 2019 , 8 ( 9 ): 1472.

Immunotherapy for pancreatic cancer: barriers and breakthroughs-torphy-2018-annals of gastroenterological surgery-wiley online library [EB/OL ] . [ 2024-12-19 ] . https://onlinelibrary.wiley.com/doi/10.1002/ags3.12176 https://onlinelibrary.wiley.com/doi/10.1002/ags3.12176 https://onlinelibrary.wiley.com/doi/10.1002/ags3.12176.

YE X R , YU Y , ZHENG X H , et al. Clinical immunotherapy in pancreatic cancer [J ] . Cancer Immunol Immunother , 2024 , 73 ( 4 ): 64.

LIU R J , LI J N , LIU L , et al. Tumor-associated macrophages (TAMs): constructing an immunosuppressive microenvironment bridge for pancreatic ductal adenocarcinoma (PDAC) [J ] . Cancer Pathog Ther , 2024 .

ZHENG H J , YANG X Z , HUANG N , et al. Chimeric antigen receptor macrophages targeting c-MET (CAR-M-c-MET) inhibit pancreatic cancer progression and improve cytotoxic chemotherapeutic efficacy [J ] . Mol Cancer , 2024 , 23 ( 1 ): 270.

Pancreatic cancer and cachexia-metabolic mechanisms and novel insights-PubMed [EB/OL ] . [ 2024-12-19 ] . https://pubmed.ncbi.nlm.nih.gov/32466362/ https://pubmed.ncbi.nlm.nih.gov/32466362/ https://pubmed.ncbi.nlm.nih.gov/32466362/.

YULE M S , BROWN L R , WALLER R , et al. Cancer cachexia [J ] . BMJ , 2024 , 387 : e080040 .

LIU M Y , REN Y , ZHOU Z J , et al. The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia [J ] . Cancer Cell , 2024 , 42 ( 5 ): 885 - 903 .e4. DOI: 10.1016/j.ccell.2024.03.009 http://doi.org/10.1016/j.ccell.2024.03.009

MIZRAHI J D , SURANA R , VALLE J W , et al. Pancreatic cancer [J ] . Lancet , 2020 , 395 ( 10242 ): 2008 - 2020 . DOI: S0140-6736(20)30974-0 http://doi.org/S0140-6736(20)30974-0

STOOP T F , THEIJSE R T , SEELEN L W F , et al. Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer [J ] . Nat Rev Gastroenterol Hepatol , 2024 , 21 ( 2 ): 101 - 124 . DOI: 10.1038/s41575-023-00856-2 http://doi.org/10.1038/s41575-023-00856-2

HE J X , LV N , YANG Z Y , et al. Comparing upfront surgery with neoadjuvant treatments in patients with resectable, borderline resectable or locally advanced pancreatic cancer: a systematic review and network meta-analysis of randomized clinical trials [J ] . Int J Surg , 2024 , 110 ( 6 ): 3900 - 3909 . DOI: 10.1097/JS9.0000000000001313 http://doi.org/10.1097/JS9.0000000000001313

CONROY T , HAMMEL P , HEBBAR M , et al. FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer [J ] . N Engl J Med , 2018 , 379 ( 25 ): 2395 - 2406 .

NEOPTOLEMOS J P , PALMER D H , GHANEH P , et al. Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial [J ] . Lancet , 2017 , 389 ( 10073 ): 1011 - 1024 . DOI: S0140-6736(16)32409-6 http://doi.org/S0140-6736(16)32409-6

CONROY T , DESSEIGNE F , YCHOU M , et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer [J ] . N Engl J Med , 2011 , 364 ( 19 ): 1817 - 1825 .

SUKER M , BEUMER B R , SADOT E , et al. FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis [J ] . Lancet Oncol , 2016 , 17 ( 6 ): 801 - 810 . DOI: S1470-2045(16)00172-8 http://doi.org/S1470-2045(16)00172-8

LABORI K J , BRATLIE S O , ANDERSSON B , et al. Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial [J ] . Lancet Gastroenterol Hepatol , 2024 , 9 ( 3 ): 205 - 217 .

GOLAN T , KINDLER H L , PARK J O , et al. Geographic and ethnic heterogeneity of germline BRCA1 or BRCA2 mutation prevalence among patients with metastatic pancreatic cancer screened for entry into the POLO trial [J ] . J Clin Oncol , 2020 , 38 ( 13 ): 1442 - 1454 .

National Comprehensive Cancer Network . Pancreatic adenocarcinoma, version 2.2024. NCCN clinical practice guidelines in oncology [EB/OL ] . [ 2024-12-19 ] . https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1455 https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1455 https://www.nccn.org/guidelines/guidelines-detail?category=1 & id=1455.

XIAO M M , TANG R , PAN H Q , et al. TPX2 serves as a novel target for expanding the utility of PARPi in pancreatic cancer through conferring synthetic lethality [J ] . Gut , 2024 : gutjnl- 2024 - 332782 .

GE W Y , WANG Y L , QUAN M , et al. Activation of the PI3K/AKT signaling pathway by ARNTL2 enhances cellular glycolysis and sensitizes pancreatic adenocarcinoma to erlotinib [J ] . Mol Cancer , 2024 , 23 ( 1 ): 48.

MOORE M J , GOLDSTEIN D , HAMM J , et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase Ⅲ trial of the National Cancer Institute of Canada Clinical Trials Group [J ] . J Clin Oncol , 2007 , 25 ( 15 ): 1960 - 1966 .

CREEDEN J F , SEVIER J , ZHANG J T , et al. Smart exosomes enhance PDAC targeted therapy [J ] . J Control Release , 2024 , 368 : 413 - 429 .

TIMMER F E F , GEBOERS B , RUARUS A H , et al. MRI-guided stereotactic ablative body radiotherapy versus CT-guided percutaneous irreversible electroporation for locally advanced pancreatic cancer (CROSSFIRE): a single-centre, open-label, randomised phase 2 trial [J ] . Lancet Gastroenterol Hepatol , 2024 , 9 ( 5 ): 448 - 459 .

TIMMER F E F , GEBOERS B , NIEUWENHUIZEN S , et al. Pancreatic cancer and immunotherapy: a clinical overview [J ] . Cancers (Basel) , 2021 , 13 ( 16 ): 4138.

TAO J X , YANG G , ZHOU W C , et al. Targeting hypoxic tumor microenvironment in pancreatic cancer [J ] . J Hematol Oncol , 2021 , 14 ( 1 ): 14.

CHENG K , LI X Y , LV W R , et al. Spatial interactions of immune cells as potential predictors to efficacy of toripalimab plus chemotherapy in locally advanced or metastatic pancreatic ductal adenocarcinoma: a phase Ⅰb/Ⅱ trial [J ] . Signal Transduct Target Ther , 2024 , 9 : 321 .

GOURGOU-BOURGADE S , BASCOUL-MOLLEVI C , DESSEIGNE F , et al. Impact of FOLFIRINOX compared with gemcitabine on quality of life in patients with metastatic pancreatic cancer: results from the PRODIGE 4/ACCORD 11 randomized trial [J ] . J Clin Oncol , 2013 , 31 ( 1 ): 23 - 29 .

GIORDANO G , MILELLA M , LANDRISCINA M , et al. Prognostic analysis and outcomes of metastatic pancreatic cancer patients receiving nab-paclitaxel plus gemcitabine as second or later-line treatment [J ] . Cancer Med , 2024 , 13 ( 12 ): e7345.

VON HOFF D D , ERVIN T , ARENA F P , et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine [J ] . N Engl J Med , 2013 , 369 ( 18 ): 1691 - 1703 .

SHA H Z , TONG F , NI J Y , et al. First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase Ⅱ trial [J ] . Signal Transduct Target Ther , 2024 , 9 ( 1 ): 143.

ROJAS L A , SETHNA Z , SOARES K C , et al. Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer [J ] . Nature , 2023 , 618 ( 7963 ): 144 - 150 .

PANT S , WAINBERG Z A , WEEKES C D , et al. Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial [J ] . Nat Med , 2024 , 30 ( 2 ): 531 - 542 . DOI: 10.1038/s41591-023-02760-3 http://doi.org/10.1038/s41591-023-02760-3

CLARK C E , HINGORANI S R , MICK R , et al. Dynamics of the immune reaction to pancreatic cancer from inception to invasion [J ] . Cancer Res , 2007 , 67 ( 19 ): 9518 - 9527 . DOI: 10.1158/0008-5472.CAN-07-0175 http://doi.org/10.1158/0008-5472.CAN-07-0175

MUSHER B L , ROWINSKY E K , SMAGLO B G , et al. LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001): results from arm 1 of a non-randomised, single-centre, phase 1/2 study [J ] . Lancet Oncol , 2024 , 25 ( 4 ): 488 - 500 . DOI: 10.1016/S1470-2045(24)00079-2 http://doi.org/10.1016/S1470-2045(24)00079-2

PARK W , CHAWLA A , O’REILLY E . Pancreatic cancer: a review [J ] . JAMA , 2021 , 326 ( 9 ): 851 - 862 . DOI: 10.1001/jama.2021.13027 http://doi.org/10.1001/jama.2021.13027

OSIPOV A , NIKOLIC O , GERTYCH A , et al. The Molecular Twin artificial-intelligence platform integrates multi-omic data to predict outcomes for pancreatic adenocarcinoma patients [J ] . Nat Cancer , 2024 , 5 ( 2 ): 299 - 314 .

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Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Pancreatic Cancer Institute, Fudan University; Shanghai Pancreatic Cancer Institute

复旦大学附属肿瘤医院胰腺外科，复旦大学胰腺肿瘤研究所，上海市胰腺肿瘤研究所，复旦大学上海医学院肿瘤学系

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Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University

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