Current status and future perspectives of antibody-drug conjugates in breast cancer therapy

Jialin LIN; Wenna WANG; Binghe XU

doi:10.19401/j.cnki.1007-3639.2025.02.002

您当前的位置：

首页 >

文章列表页 >

Current status and future perspectives of antibody-drug conjugates in breast cancer therapy

Specialist's Commentary | 更新时间：2025-12-31

- Current status and future perspectives of antibody-drug conjugates in breast cancer therapy
- China Oncology Vol. 35, Issue 2, Pages: 154-166(2025)
- 作者机构：
  
  国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院、北京协和医学院肿瘤医院内科，北京 100021
- 作者简介：
- 基金信息：
  
  CAMS Innovation Fund for Medical Sciences (CIFMS)(2021-12M-1-014);CAMS Innovation Fund for Medical Sciences (CIFMS)(2022-12M-2-002)
- DOI：10.19401/j.cnki.1007-3639.2025.02.002
  CLC： R737.9
- Received：29 December 2024，
  
  Revised：2025-02-11，
  
  Published：28 February 2025
- 稿件说明：
移动端阅览
Jialin LIN, Wenna WANG, Binghe XU. Current status and future perspectives of antibody-drug conjugates in breast cancer therapy[J]. China Oncology, 2025, 35(2): 154-166.
DOI：

Jialin LIN, Wenna WANG, Binghe XU. Current status and future perspectives of antibody-drug conjugates in breast cancer therapy[J]. China Oncology, 2025, 35(2): 154-166. DOI： 10.19401/j.cnki.1007-3639.2025.02.002.

摘要

抗体药物偶联物（antibody-drug conjugate，ADC）作为乳腺癌精准治疗的突破性药物，其独特的靶向递送机制能够有效地提高抗肿瘤治疗的选择性，并降低传统化疗的非特异性毒性。近年来，ADC在乳腺癌治疗中的应用范围不断拓展，尤其是在人表皮生长因子受体2（human epidermal growth factor receptor 2，HER2）阳性及HER2低表达乳腺癌中的成功应用，显著改变了疾病的治疗格局。其中，恩美曲妥珠单抗（trastuzumab emtansine，T-DM1）是首个取代拉帕替尼+卡培他滨方案，成为HER2阳性乳腺癌二线治疗的ADC类药，而德曲妥珠单抗（trastuzumab deruxtecan，DS-8201，T-DXd）在DESTINY-Breast04研究中展现出对HER2低表达乳腺癌的显著疗效，并成为首个获批用于该亚型患者的ADC。针对滋养层细胞表面抗原2（trophoblast cell surface antigen 2，Trop-2）靶点的ADC如戈沙妥珠单抗（sacituzumab govitecan，SG）也已在三阴性乳腺癌（triple-negative advanced breast cancer，TNBC）及激素受体阳性/HER2阴性乳腺癌患者中展现出良好的临床获益。此外，新一代ADC技术的优化，如提高连接子稳定性、优化药物抗体比（drug-to-antibody ratio，DAR）及增强旁观者效应，进一步提升了药物的抗肿瘤活性及安全性，使其成为乳腺癌精准治疗的重要发展方向。虽然ADC药物在提高疗效的同时仍可能伴随一定的靶点相关及载荷相关的不良反应，但随着管理策略的不断优化，其安全性已得到有效提升。HER2靶向ADC的不良反应主要包括T-DXd相关的间质性肺病（interstitial lung disease，ILD）、T-DM1的血小板减少及肝功能异常，而Trop-2靶向ADC如SG的血液毒性及胃肠道反应亦需关注。值得注意的是，新一代ADC在结构优化后已显著改善其安全性，并且通过早期监测、个体化剂量调整及支持治疗，可以有效地降低严重不良事件的发生风险。临床上ADC治疗的毒性管理已趋向成熟，绝大多数不良反应均可通过优化治疗方案和联合支持治疗得到有效控制。因此，在实际临床操作中，应综合考虑患者的个体因素、既往治疗史及伴随疾病情况，以制定最优的ADC应用策略，确保疗效与安全性的最大化。随着ADC技术的不断进步，未来乳腺癌治疗将更加精准化。新型HER2-Trop-2双靶点ADC的研发为HER2低表达及HER2阴性乳腺癌患者提供了新的治疗可能，而T-DXd联合免疫检查点抑制剂（immune checkpoint inhibitor，ICI）、CDK4/6抑制剂及多腺苷二磷酸核糖聚合酶[poly（ADP-ribose）polymerase，PARP]抑制剂的研究显示出协同抗肿瘤效应。本综述系统总结乳腺癌ADC的最新研究进展，重点探讨HER2及Trop-2靶向ADC的临床应用、安全性管理策略及新型ADC的发展趋势，旨在为乳腺癌的精准治疗提供参考。

Abstract

Antibody-drug conjugates (ADCs) represent a breakthrough in precision therapy for breast cancer

offering a unique targeted drug delivery mechanism that enhances tumor selectivity while reducing the nonspecific toxicity associated with conventional chemotherapy. In recent years

the clinical applications of ADCs in breast cancer have expanded significantly

particularly in human epidermal growth factor receptor 2 (HER2)-positive and HER2-low breast cancer

reshaping the therapeutic landscape. Trastuzumab emtanserin (T-DM1) was the first ADC drug to replace lapatinib plus capecitabine as a second-line treatment for HER2-positive breast cancer

while trastuzumab deruxtecan (T-DXd) demonstrated remarkable efficacy in HER2-low breast cancer in the DESTINY-Breast04 trial

becoming the first approved ADC for this patient subgroup. Furthermore

trophoblast cell surface antigen 2 (Trop-2)-targeting ADCs

such as sacituzumab govitecan (SG)

have shown promising clinical benefits in patients with triple-negative breast cancer (TNBC) and hormone receptor-positive/HER2-negative breast cancer. Advances in next-generation ADC technologies

including improvements in linker stability

drug-to-antibody ratio (DAR) optimization

and enhanced bystander effects

have further improved the therapeutic efficacy and safety profile of these agents

reinforcing their role in the precision treatment of breast cancer. Although ADCs have demonstrated substantial clinical benefits

they are associated with target- and payload-related toxicities. However

with ongoing advancements in management strategies

their safety profile has been significantly improved. HER2-targeting ADCs present specific adverse events

including interstitial lung disease (ILD) associated with T-DXd

thrombocytopenia

and liver function abnormalities observed with T-DM1

while Trop-2-targeting ADCs such as SG are linked to hematologic toxicity and gastrointestinal side effects. Notably

structural optimizations in next-generation ADCs have led to significant improvements in their safety profile. Early monitoring

individualized dose modifications

and supportive care measures have been shown to effectively reduce the incidence of severe adverse events. Clinical studies indicate that toxicity management strategies for ADCs have matured

with most adverse effects being effectively controlled through optimized treatment regimens and adjunctive supportive care. Thus

in clinical practice

it is essential to consider patient-specific factors

prior treatment history

and comorbidities to devise an optimal ADC treatment strategy that maximizes both efficacy and safety. As ADC technology continues to evolve

breast cancer treatment is expected to become increasingly precise. The development of novel HER2-Trop-2 bispecific ADCs offers new therapeutic options for patients with HER2-low and HER2-negative breast cancer. Additionally

studies investigating the combination of T-DXd with immune checkpoint inhibitors (ICIs)

CDK4/6 inhibitors

and poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated synergistic antitumor effects

further expanding the prospects for precision medicine in breast cancer. This review systematically summarized the latest advancements in ADCs for breast cancer

with a focus on the clinical applications

safety management strategies

and future development of HER2- and Trop-2-targeting ADCs

aiming to provide valuable insights for the future of precision breast cancer treatment.

关键词

Keywords

references

DUMONTET C , REICHERT J M , SENTER P D , et al . Antibody-drug conjugates come of age in oncology [J ] . Nat Rev Drug Discov , 2023 , 22 ( 8 ): 641 - 661 . DOI: 10.1038/s41573-023-00709-2 http://doi.org/10.1038/s41573-023-00709-2

BECK A , GOETSCH L , DUMONTET C , et al . Strategies and challenges for the next generation of antibody-drug conjugates [J ] . Nat Rev Drug Discov , 2017 , 16 ( 5 ): 315 - 337 . DOI: 10.1038/nrd.2016.268 http://doi.org/10.1038/nrd.2016.268

CHAU C H , STEEG P S , FIGG W D . Antibody-drug conjugates for cancer [J ] . Lancet , 2019 , 394 ( 10200 ): 793 - 804 . DOI: S0140-6736(19)31774-X http://doi.org/S0140-6736(19)31774-X

PEREZ H L , CARDARELLI P M , DESHPANDE S , et al . Antibody-drug conjugates: current status and future directions [J ] . Drug Discov Today , 2014 , 19 ( 7 ): 869 - 881 . DOI: 10.1016/j.drudis.2013.11.004 http://doi.org/10.1016/j.drudis.2013.11.004

GOLDENBERG D M , SHARKEY R M . Sacituzumab govitecan, a novel, third-generation, antibody-drug conjugate (ADC) for cancer therapy [J ] . Expert Opin Biol Ther , 2020 , 20 ( 8 ): 871 - 885 . DOI: 10.1080/14712598.2020.1757067 http://doi.org/10.1080/14712598.2020.1757067

HUNTER F W , BARKER H R , LIPERT B , et al . Mechanisms of resistance to trastuzumab emtansine (T-DM1) in HER2-positive breast cancer [J ] . Br J Cancer , 2020 , 122 ( 5 ): 603 - 612 .

OGITANI Y , HAGIHARA K , OITATE M , et al . Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity [J ] . Cancer Sci , 2016 , 107 ( 7 ): 1039 - 1046 .

VERMA S , MILES D , GIANNI L , et al . Trastuzumab emtansine for HER2-positive advanced breast cancer [J ] . N Engl J Med , 2012 , 367 ( 19 ): 1783 - 1791 .

HURVITZ S A , MARTIN M , SYMMANS W F , et al . Neoadjuvant trastuzumab, pertuzumab, and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer (KRISTINE): a randomised, open-label, multicentre, phase 3 trial [J ] . Lancet Oncol , 2018 , 19 ( 1 ): 115 - 126 . DOI: S1470-2045(17)30716-7 http://doi.org/S1470-2045(17)30716-7

OGITANI Y , AIDA T , HAGIHARA K , et al . DS-8201a, a novel HER2-targeting ADC with a novel DNA topoisomerase I inhibitor, demonstrates a promising antitumor efficacy with differentiation from T-DM1 [J ] . Clin Cancer Res , 2016 , 22 ( 20 ): 5097 - 5108 .

SHITARA K , IWATA H , TAKAHASHI S , et al . Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive gastric cancer: a dose-expansion, phase 1 study [J ] . Lancet Oncol , 2019 , 20 ( 6 ): 827 - 836 . DOI: S1470-2045(19)30088-9 http://doi.org/S1470-2045(19)30088-9

TAMURA K , TSURUTANI J , TAKAHASHI S , et al . Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study [J ] . Lancet Oncol , 2019 , 20 ( 6 ): 816 - 826 . DOI: S1470-2045(19)30097-X http://doi.org/S1470-2045(19)30097-X

DOI T , SHITARA K , NAITO Y , et al . Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody-drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study [J ] . Lancet Oncol , 2017 , 18 ( 11 ): 1512 - 1522 . DOI: S1470-2045(17)30604-6 http://doi.org/S1470-2045(17)30604-6

MODI S N , SAURA C , YAMASHITA T , et al . Trastuzumab deruxtecan in previously treated HER2-positive breast cancer [J ] . N Engl J Med , 2020 , 382 ( 7 ): 610 - 621 .

CORTÉS J , HURVITZ S A , IM S A , et al . Trastuzumab deruxtecan versus trastuzumab emtansine in HER2-positive metastatic breast cancer: long-term survival analysis of the DESTINY-Breast03 trial [J ] . Nat Med , 2024 , 30 ( 8 ): 2208 - 2215 .

YAMASHITA T , SOHN J H , TOKUNAGA E , et al . Trastuzumab deruxtecan versus treatment of physician’s choice in previously treated Asian patients with HER2-low unresectable/metastatic breast cancer: subgroup analysis of the DESTINY-Breast04 study [J ] . Breast Cancer , 2024 , 31 ( 5 ): 858 - 868 .

SCHETTINI F , CHIC N , BRASÓ-MARISTANY F , et al . Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer [J ] . NPJ Breast Cancer , 2021 , 7 ( 1 ): 1 . DOI: 10.1038/s41523-020-00208-2 http://doi.org/10.1038/s41523-020-00208-2

MODI S N , JACOT W , YAMASHITA T , et al . Trastuzumab deruxtecan in previously treated HER2-low advanced breast cancer [J ] . N Engl J Med , 2022 , 387 ( 1 ): 9 - 20 .

MODI S , JACOT W , IWATA H , et al . Trastuzumab deruxtecan (T-DXd) versus treatment of physician’s choice (TPC) in patients (pts) with HER2-low unresectable and/or metastatic breast cancer (mBC): updated survival results of the randomized, phase Ⅲ DESTINY-Breast04 study [J ] . Ann Oncol , 2023 , 34 : S334-S335.

WANG J Y , LIU Y J , ZHANG Q Y , et al . Disitamab vedotin, a HER2-directed antibody-drug conjugate, in patients with HER2-overexpression and HER2-low advanced breast cancer: a phase Ⅰ/Ⅰb study [J ] . Cancer Commun (Lond) , 2024 , 44 ( 7 ): 833 - 851 .

DAL CORSO A , CAZZAMALLI S , GÉBLEUX R , et al . Protease-cleavable linkers modulate the anticancer activity of noninternalizing antibody-drug conjugates [J ] . Bioconjug Chem , 2017 , 28 ( 7 ): 1826 - 1833 .

CHEN M T , HUANG R Q , CHEN R S , et al . Optimal sequential strategies for antibody-drug conjugate in metastatic breast cancer: evaluating efficacy and cross-resistance [J ] . Oncologist , 2024 , 29 ( 8 ): e957-e966.

SHAO Z , WANG R , ZHANG J , et al . A randomized, multicenter, open-label phase Ⅱ neoadjuvant study to evaluate the safety and efficacy of HER2-ADC disitamab vedotin in combination toripalimab or sequence chemotherapy in participants with HR-negative, HER2 low-expressing breast cancer [J ] . Ann Oncol , 2024 , 35 : S347 .

QU F , LI W , YI Y . Efficacy and safety of the recombinant humanized anti-HER2 monoclonal antibody-MMAE conjugate RC48-ADC in patients with HER2-positive or HER2-low expressing, locally advanced or metastatic breast cancer: a single-arm phase Ⅱstudy [J ] . Ann Oncol , 2023 , 34 : S348 .

ZHANG J , LIU R J , GAO S P , et al . Phase Ⅰ study of A166, an antibody-drug conjugate in advanced HER2-expressing solid tumours [J ] . NPJ Breast Cancer , 2023 , 9 ( 1 ): 28 .

SUBHAN M A , TORCHILIN V P . Advances in targeted therapy of breast cancer with antibody-drug conjugate [J ] . Pharmaceutics , 2023 , 15 ( 4 ): 1242 .

LOPEZ D M , BARVE M , WANG J , et al . A phase Ⅰ study of A166, a novel anti-HER2 antibody-drug conjugate (ADC), in patients with locally advanced/metastatic solid tumors [J ] . Mol Cancer Ther , 2019 , 18 ( 12_Suppl ): B005 .

SKIDMORE L , SAKAMURI S , KNUDSEN N A , et al . ARX788, a site-specific anti-HER2 antibody-drug conjugate, demonstrates potent and selective activity in HER2-low and T-DM1-resistant breast and gastric cancers [J ] . Mol Cancer Ther , 2020 , 19 ( 9 ): 1833 - 1843 . DOI: 10.1158/1535-7163.MCT-19-1004 http://doi.org/10.1158/1535-7163.MCT-19-1004

ZHANG J , JI D M , SHEN W N , et al . Phase Ⅰ trial of a novel anti-HER2 antibody-drug conjugate, ARX788, for the treatment of HER2-positive metastatic breast cancer [J ] . Clin Cancer Res , 2022 : OF1-OF10.

LI Q , CHENG Y , TONG Z S , et al . HER2-targeting antibody drug conjugate FS-1502 in HER2-expressing metastatic breast cancer: a phase 1a/1b trial [J ] . Nat Commun , 2024 , 15 ( 1 ): 5158 . DOI: 10.1038/s41467-024-48798-w http://doi.org/10.1038/s41467-024-48798-w

LI Q , WANG X , CHENG Y , et al . Abstract P4-01-07: FS-1502, an anti-HER2 ADC, in patients with HER2-expressing advanced solid tumors: a phase 1a dose-escalation study [J ] . Cancer Res , 2023 , 83 ( 5_Suppl ): P4-1-07-P4-01-07.

PAN H M , YUAN X L , ZHENG Y , et al . FS-1502 in patients with HER2 high expression, locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma: an open-label, multicenter, phase Ⅱ study [J ] . J Clin Oncol , 2024 , 42 ( 16_suppl ): e15000 .

YAO H R , YAN M , TONG Z S , et al . Safety, efficacy, and pharmacokinetics of SHR-A1811, a human epidermal growth factor receptor 2-directed antibody-drug conjugate, in human epidermal growth factor receptor 2-expressing or mutated advanced solid tumors: a global phase Ⅰ trial [J ] . J Clin Oncol , 2024 , 42 ( 29 ): 3453 - 3465 .

CORTESI M , ZANONI M , MALTONI R , et al . Trop2 (trophoblast cell-surface antigen 2): a drug target for breast cancer [J ] . Expert Opin Ther Targets , 2022 , 26 ( 7 ): 593 - 602 .

STEPAN L P , TRUEBLOOD E S , HALE K R , et al . Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: potential implications as a cancer therapeutic target [J ] . J Histochem Cytochem , 2011 , 59 ( 7 ): 701 - 710 . DOI: 10.1369/0022155411410430 http://doi.org/10.1369/0022155411410430

VIDULA N , YAU C , RUGO H . Trophoblast cell surface antigen 2 gene (TACSTD2) expression in primary breast cancer [J ] . Breast Cancer Res Treat , 2022 , 194 ( 3 ): 569 - 575 .

ZHAO W , KUAI X W , ZHOU X Y , et al . Trop2 is a potential biomarker for the promotion of EMT in human breast cancer [J ] . Oncol Rep , 2018 , 40 ( 2 ): 759 - 766 . DOI: 10.3892/or.2018.6496 http://doi.org/10.3892/or.2018.6496

HU Y X , ZHU Y X , QI D , et al . Trop2-targeted therapy in breast cancer [J ] . Biomark Res , 2024 , 12 ( 1 ): 82 . DOI: 10.1186/s40364-024-00633-6 http://doi.org/10.1186/s40364-024-00633-6

CARDILLO T M , GOVINDAN S V , SHARKEY R M , et al . Sacituzumab govitecan (IMMU-132), an anti-trop-2/SN-38 antibody-drug conjugate: characterization and efficacy in pancreatic, gastric, and other cancers [J ] . Bioconjug Chem , 2015 , 26 ( 5 ): 919 - 931 .

GOLDENBERG D M , CARDILLO T M , GOVINDAN S V , et al . Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC) [J ] . Oncotarget , 2015 , 6 ( 26 ): 22496 - 22512 .

WEISS J , GLODE A , MESSERSMITH W A , et al . Sacituzumab govitecan: breakthrough targeted therapy for triple-negative breast cancer [J ] . Expert Rev Anticancer Ther , 2019 , 19 ( 8 ): 673 - 679 .

GRINDA T , RASSY E , PISTILLI B . Antibody-drug conjugate revolution in breast cancer: the road ahead [J ] . Curr Treat Options Oncol , 2023 , 24 ( 5 ): 442 - 465 .

BARDIA A , MAYER I A , VAHDAT L T , et al . Sacituzumab govitecan-hziy in refractory metastatic triple-negative breast cancer [J ] . N Engl J Med , 2019 , 380 ( 8 ): 741 - 751 .

BARDIA A , HURVITZ S A , TOLANEY S M , et al . Sacituzumab govitecan in metastatic triple-negative breast cancer [J ] . N Engl J Med , 2021 , 384 ( 16 ): 1529 - 1541 .

LOIBL S , LOIRAT D , TOLANEY S M , et al . Health-related quality of life in the phase Ⅲ ASCENT trial of sacituzumab govitecan versus standard chemotherapy in metastatic triple-negative breast cancer [J ] . Eur J Cancer , 2023 , 178 : 23 - 33 .

XU B H , MA F , WANG T , et al . A phase Ⅱb, single arm, multicenter trial of sacituzumab govitecan in Chinese patients with metastatic triple-negative breast cancer who received at least two prior treatments [J ] . Int J Cancer , 2023 , 152 ( 10 ): 2134 - 2144 .

XU B H , WANG S S , YAN M , et al . Sacituzumab govitecan in HR + HER2 - metastatic breast cancer: the randomized phase 3 EVER-132-002 trial [J ] . Nat Med , 2024 , 30 ( 12 ): 3709 - 3716 .

CHENG Y , YUAN X , TIAN Q , et al . Preclinical profiles of SKB264, a novel anti-Trop2 antibody conjugated to topoisomerase inhibitor, demonstrated promising antitumor efficacy compared to IMMU-132 [J ] . Front Oncol , 2022 , 12 : 951589 .

OKAJIMA D , YASUDA S , MAEJIMA T , et al . Datopotamab deruxtecan, a novel Trop2-directed antibody-drug conjugate, demonstrates potent antitumor activity by efficient drug delivery to tumor cells [J ] . Mol Cancer Ther , 2021 , 20 ( 12 ): 2329 - 2340 .

BARDIA A , JHAVERI K , IM S A , et al . Datopotamab deruxtecan (Dato-DXd) vs chemotherapy in previously-treated inoperable or metastatic hormone receptor-positive, HER2-negativ e (HR + /HER2 - ) breast cancer (BC): primary results from the randomised phase Ⅲ TROPION-Breast01 trial [J ] . Ann Oncol , 2023 , 34 : S1264-S1265.

危彤 , 袁芃 . 抗人表皮生长因子受体2抗体药物偶联物在人表皮生长因子受体2低表达泛瘤种中的治疗进展 [J ] . 中华肿瘤杂志 , 2024 , 46 ( 3 ): 211 - 220 .

WEI T , YUAN P . Advances in the treatment of anti-HER2 antibody drug conjugates in pan-tumor with low HER2 expression [J ] . Chin J Oncol , 2024 , 46 ( 3 ): 211 - 220 .

BRASÓ-MARISTANY F , FERRERO-CAFIERO J M , FALATO C , et al . Patritumab deruxtecan in HER2-negative breast cancer: part B results of the window-of-opportunity SOLTI-1805 TOT-HER3 trial and biological determinants of early response [J ] . Nat Commun , 2024 , 15 ( 1 ): 5826 .

HAMILTON E P , DOSUNMU O , SHASTRY M , et al . A phase 2 study of HER3-DXd in patients (pts) with metastatic breast cancer (MBC) [J ] . J Clin Oncol , 2023 , 41 ( 16_suppl ): 1004 .

MAKAWITA S , MERIC-BERNSTAM F . Antibody-drug conjugates: patient and treatment selection [J ] . Am Soc Clin Oncol Educ Book , 2020 , 40 : 1 - 10 . DOI: 10.1200/EDBK_280775 http://doi.org/10.1200/EDBK_280775

YAMAGUCHI K , BANG Y J , IWASA S , et al . Trastuzumab deruxtecan (T-DXd; DS-8201) in patients with HER2-positive advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma: final overall survival (OS) results from a randomized, multicenter, open-label, phase 2 study (DESTINY-Gastric01) [J ] . J Clin Oncol , 2022 , 40 ( 4_suppl ): 242 .

CONNORS J M , JURCZAK W , STRAUS D J , et al . Brentuximab vedotin with chemotherapy for stage Ⅲ or Ⅳ Hodgkin’s lymphoma [J ] . N Engl J Med , 2018 , 378 ( 4 ): 331 - 344 .

CORTÉS J , KIM S B , CHUNG W P , et al . Trastuzumab deruxtecan (T-DXd) vs trastuzumab emtansine (T-DM1) in patients (Pts) with HER2 + metastatic breast cancer (mBC): results of the randomized phase Ⅲ DESTINY-Breast03 study [J ] . Ann Oncol , 2021 , 32 : S1287 -S1288.

中国抗癌协会肿瘤药物临床研究专业委员会 , 国家抗肿瘤药物临床应用监测专家委员会 , 国家肿瘤质控中心乳腺癌专家委员会 , 等 . 抗体药物偶联物治疗恶性肿瘤临床应用中国专家共识(2023版) [J ] . 中华肿瘤杂志 , 2023 , 45 ( 9 ): 741 - 762 .

Society of Clinical Oncology Drug Research of China Anti-Cancer Association, National Expert Society for Monitoring the Clinical Application of Anti-Cancer Drugs , Breast Cancer Expert Society of the National Cancer Center . China expert consensus on clinical application of antibody drug conjugates in the treatment of malignant tumors (2023 edition) [J ] . Chin J Oncol , 2023 , 45 ( 9 ): 741 - 762 .

FONTANELLA C , BOLZONELLO S , LEDERER B , et al . Management of breast cancer patients with chemotherapy-induced neutropenia or febrile neutropenia [J ] . Breast Care (Basel) , 2014 , 9 ( 4 ): 239 - 245 .

STRAUS D J , DŁUGOSZ-DANECKA M , ALEKSEEV S , et al . Brentuximab vedotin with chemotherapy for stage Ⅲ/Ⅳ classical Hodgkin lymphoma: 3-year update of the ECHELON-1 study [J ] . Blood , 2020 , 135 ( 10 ): 735 - 742 .

SHENG X N , YAN X Q , WANG L , et al . Open-label, multicenter, phase Ⅱ study of RC48-ADC, a HER2-targeting antibody-drug conjugate, in patients with locally advanced or metastatic urothelial carcinoma [J ] . Clin Cancer Res , 2021 , 27 ( 1 ): 43 - 51 .

HORWITZ S , O’CONNOR O A , PRO B , et al . Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial [J ] . Lancet , 2019 , 393 ( 10168 ): 229 - 240 . DOI: S0140-6736(18)32984-2 http://doi.org/S0140-6736(18)32984-2

XU Y Y , WANG Y K , GONG J F , et al . Phase Ⅰ study of the recombinant humanized anti-HER2 monoclonal antibody-MMAE conjugate RC48-ADC in patients with HER2-positive advanced solid tumors [J ] . Gastric Cancer , 2021 , 24 ( 4 ): 913 - 925 .

吴婷婷 , 朱海斌 , 任春霞 , 等 . 抗体偶联药物相关周围神经病变的研究进展 [J ] . 中国新药与临床杂志 , 2024 : 1 - 10 .

WU T T , ZHU H B , REN C X , et al . Research progress on antibody coupled drug-induced peripheral neuropathy [J ] . Chin J New Drug Clin Rem , 2024 : 1 - 10 .

中国抗癌协会肿瘤支持治疗专业委员会 , 中国抗癌协会肿瘤临床化疗专业委员会 . 化疗诱导的周围神经病变诊治中国专家共识(2022版) [J ] . 中华肿瘤杂志 , 2022 , 44 ( 9 ): 928 - 934 .

Society of Oncologic Supportive Therapy of the Chinese Anti-Cancer Association, Society of Clinical Chemotherapy of the Chinese Anti-Cancer Association . China expert consensus on diagnosis and treatment of chemotherapy-induced peripheral neuropathy (2022 edition) [J ] . Chin J Oncol , 2022 , 44 ( 9 ): 928 - 934 .

HERSHMAN D L , LACCHETTI C , DWORKIN R H , et al . Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline [J ] . J Clin Oncol , 2014 , 32 ( 18 ): 1941 - 1967 . DOI: 10.1200/JCO.2013.54.0914 http://doi.org/10.1200/JCO.2013.54.0914

BARDIA A , HARNDEN K , MAURO L , et al . Clinical practices and institutional protocols on prophylaxis, monitoring, and management of selected adverse events associated with trastuzumab deruxtecan [J ] . Oncologist , 2022 , 27 ( 8 ): 637 - 645 . DOI: 10.1093/oncolo/oyac107 http://doi.org/10.1093/oncolo/oyac107

KROP I E , KIM S B , MARTIN A G , et al . Trastuzumab emtansine versus treatment of physician’s choice in patients with previously treated HER2-positive metastatic breast cancer (TH3RESA): final overall survival results from a randomised open-label phase 3 trial [J ] . Lancet Oncol , 2017 , 18 ( 6 ): 743 - 754 .

抗肿瘤药物相关间质性肺病诊治专家共识专家委员会 . 抗肿瘤药物相关间质性肺病诊治专家共识 [J ] . 中华肿瘤杂志 , 2022 , 44 ( 7 ): 693 - 702 .

Expert Consensus Committee on the Diagnosis and Treatment of Interstitial Lung Disease Related to Antitumor Drugs . Expert consensus on diagnosis and treatment of interstitial lung disease related to antineoplastic drugs [J ] . Chin J Oncol , 2022 , 44 ( 7 ): 693 - 702 .

SPRING L M , NAKAJIMA E , HUTCHINSON J , et al . Sacituzumab govitecan for metastatic triple-negative breast cancer: clinical overview and management of potential toxicities [J ] . Oncologist , 2021 , 26 ( 10 ): 827 - 834 .

中国抗癌协会肿瘤药物临床研究专业委员会 , 国家抗肿瘤药物临床应用监测专家委员会 , 国家肿瘤质控中心乳腺癌专家委员会 , 等 . 抗体药物偶联物治疗恶性肿瘤临床应用专家共识(2020版) [J ] . 中国医学前沿杂志(电子版) , 2021 , 13 ( 1 ): 1 - 15 .

Professional Committee on Clinical Research of Oncology Drugs of China Anti-Cancer Association, Expert Committee for Monitoring the Clinical Application of Antitumor Drugs , Breast Cancer Expert Committee , et al . Expert consensus on the clinical application of antibody-drug conjugates in the treatment of malignant tumors(2020 edition) [J ] . Chin J Front Med Sci Electron Version , 2021 , 13 ( 1 ): 1 - 15 .

中国药学会医院药学专业委员会 , 中国抗癌协会肿瘤临床化疗专业委员会 . 抗体偶联药物安全性跨学科管理中国专家共识 [J ] . 中国医院药学杂志 , 2023 , 43 ( 1 ): 1 - 10 .

Hospital Pharmacy Committee of Chinese Pharmaceutical Association, Tumor Clinical Chemotherapy Committee of China Anti-Cancer Association . Interdisciplinary management of the safety associated with antibody-drug conjugates: Chinese expert consensus [J ] . Chin J Hosp Pharm , 2023 , 43 ( 1 ): 1 - 10 .

NEGISHI K , NEGISHI T , HALUSKA B A , et al . Use of speckle strain to assess left ventricular responses to cardiotoxic chemotherapy and cardioprotection [J ] . Eur Heart J Cardiovasc Imaging , 2014 , 15 ( 3 ): 324 - 331 . DOI: 10.1093/ehjci/jet159 http://doi.org/10.1093/ehjci/jet159

夏凡 , 张晶晶 , 杭永付 , 等 . 抗体药物偶联物相关眼毒性的研究进展 [J ] . 药物流行病学杂志 , 2023 , 32 ( 9 ): 985 - 990 .

XIA F , ZHANG J J , HANG Y F , et al . Research progress of drug-induced ocular toxicity of antibody-drug conjugate [J ] . Chin J Pharmacoepidemiol , 2023 , 32 ( 9 ): 985 - 990 .

FAROOQ A V , DEGLI ESPOSTI S , POPAT R , et al . Corneal epithelial findings in patients with multiple myeloma treated with antibody-drug conjugate belantamab mafodotin in the pivotal, randomized, DREAMM-2 study [J ] . Ophthalmol Ther , 2020 , 9 ( 4 ): 889 - 911 .

CONILH L , SADILKOVA L , VIRICEL W , et al . Payload diversification: a key step in the development of antibody-drug conjugates [J ] . J Hematol Oncol , 2023 , 16 ( 1 ): 3 .

CARDILLO T M , SHARKEY R M , ROSSI D L , et al . Synthetic lethality exploitation by an anti-trop-2-SN-38 antibody-drug conjugate, IMMU-132, plus PARP inhibitors in BRCA1/2 -wild-type triple-negative breast cancer [J ] . Clin Cancer Res , 2017 , 23 ( 13 ): 3405 - 3415 .

Views

2403

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Progress and prospects of CENPA-driven chromosomal instability in breast cancer: mechanisms, prognostic implications, and therapeutic perspectives

Precision diagnosis and treatment of breast cancer in the post-CDK4/6 inhibitor era

Research advances in estrogen receptor low positive early breast cancer

The latest progress and prospect of gynecological tumor treatment at 2023 ESMO

Progress of important clinical trials of breast cancer in China in 2022

Related Author

LU Ye

ZHANG Wenxiang

KONG Xiangyi

FANG Yi

WANG Jing

GAO Jidong

Bin LI

Zhonghua TAO

Related Institution

Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital& Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

Committee of Breast Cancer Society, Shanghai Anti-Cancer Association

Committee of Clinical Research on Anticancer Drugs, Shanghai Anti-Cancer Association

AI问答

⁰