Research progress and prospects of exercise intervention in comprehensive management of colorectal cancer

Yalin LI; Yan TU; Ming QUAN

doi:10.19401/j.cnki.1007-3639.2025.10.003

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Research progress and prospects of exercise intervention in comprehensive management of colorectal cancer

Specialist's Commentary | 更新时间：2025-12-31

- Research progress and prospects of exercise intervention in comprehensive management of colorectal cancer
- China Oncology Vol. 35, Issue 10, Pages: 920-928(2025)
- 作者机构：
  
  同济大学附属东方医院肿瘤科，上海 200120
- 作者简介：
- 基金信息：
  
  Shanghai Pudong New Area Health System Discipline Leader Training Program(PWRd2022-02)
- DOI：10.19401/j.cnki.1007-3639.2025.10.003
  CLC： R735.3+4
- Received：27 June 2025，
  
  Revised：2025-09-23，
  
  Published：30 October 2025
- 稿件说明：
移动端阅览
Yalin LI, Yan TU, Ming QUAN. Research progress and prospects of exercise intervention in comprehensive management of colorectal cancer[J]. China Oncology, 2025, 35(10): 920-928.
DOI：

Yalin LI, Yan TU, Ming QUAN. Research progress and prospects of exercise intervention in comprehensive management of colorectal cancer[J]. China Oncology, 2025, 35(10): 920-928. DOI： 10.19401/j.cnki.1007-3639.2025.10.003.

摘要

结直肠癌（colorectal cancer，CRC）是最常见的消化道恶性肿瘤，发病率逐年上升且呈年轻化趋势，给社会及家庭带来了沉重的卫生经济负担。现有证据表明，定期进行中度至高强度的运动锻炼，可显著降低CRC的发病风险，减轻并发症及抗肿瘤治疗相关不良反应，提高患者的生活质量，延长患者的生存期。运动锻炼作为一种简单经济的非药物干预手段，通过调节炎症信号、促进合成代谢等多组学调控网络，在CRC治疗及康复全程中具有重要意义。本文综述临床和实验研究的最新证据，强调运动锻炼在CRC全程管理中的作用不可或缺，并就相关机制进行了汇总分析。未来的研究应进一步分析各种运动类型、强度和频率对CRC的具体影响，并与放化疗等临床治疗手段相结合，探索多模式干预下的精准化方案，以最大化其临床效益。

Abstract

Colorectal cancer (CRC) is the most common malignant tumor of the digestive tract

with its incidence rate increasing annually and showing a younger-age trend

imposing heavy health and economic burdens on society and families. Regular moderate-to-vigorous physical exercise has been demonstrated to significantly reduce the risk of developing CRC

alleviate complications and adverse reactions related to anti-tumor treatment

improve patients’ quality of life

and prolong survival. As a simple and economical non-pharmacological intervention

exercise plays a crucial role throughout CRC development and treatment by regulating inflammatory signals and promoting anabolic metabolism through multi-omics regulatory networks. This article reviewed the latest evidence from clinical and experimental studies

emphasizing the indispensability of exercise in the comprehensive management of CRC patients

and provided a summary analysis of relevant mechanisms. Future research should further investigate the specific impacts of various exercise types

intensities

and frequencies on CRC

combine them with clinical treatment methods such as radiotherapy and chemotherapy

and explore precision approaches under multimodal interventions to maximize clinical benefits.

关键词

Keywords

references

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