An analysis of 52 patients of malignant parotid gland tumor

周亚燕; 李先明; 龚龙; 徐钢; 李子煌; 闫茂生; 郭轶群

doi:10.3969/j.issn.1007-3969.2013.04.011

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An analysis of 52 patients of malignant parotid gland tumor

更新时间：2025-12-31

- An analysis of 52 patients of malignant parotid gland tumor
- China Oncology Vol. 23, Issue 4, Pages: 302-307(2013)
- 作者机构：
  
  暨南大学第二临床医学院肿瘤放疗科,广东,深圳,518020
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2013.04.011
  CLC：
- Published Online：19 November 2014，
  
  Published：2013
- 稿件说明：
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周亚燕,李先明,龚龙,徐钢,李子煌,闫茂生,郭轶群. 52例腮腺恶性肿瘤患者的临床分析[J]. 中国癌症杂志, 2013, 23(4): 302-307.

周亚燕, 李先明, 龚龙, et al. An analysis of 52 patients of malignant parotid gland tumor[J]. China Oncology, 2013, 23(4): 302-307.
周亚燕,李先明,龚龙,徐钢,李子煌,闫茂生,郭轶群. 52例腮腺恶性肿瘤患者的临床分析[J]. 中国癌症杂志, 2013, 23(4): 302-307. DOI： 10.3969/j.issn.1007-3969.2013.04.011.

周亚燕, 李先明, 龚龙, et al. An analysis of 52 patients of malignant parotid gland tumor[J]. China Oncology, 2013, 23(4): 302-307. DOI： 10.3969/j.issn.1007-3969.2013.04.011.

摘要

背景与目的：大涎腺中腮腺肿瘤的发病率最高。腮腺恶性肿瘤的病理学特征复杂、临床表现和预后也各有差异。本研究旨在分析腮腺恶性肿瘤的临床特点、治疗方法及预后因素。方法：回顾性分析1989–2011年暨南大学第二临床医学院肿瘤放疗科收治的52例腮腺原发恶性肿瘤患者资料，治疗方式均为手术加术后放疗。病理亚型有：黏液表皮样癌、腺样囊性癌、腺泡细胞癌、肌上皮癌、腺癌、鳞癌和未分化癌。结果：中位随访期62个月(14~191个月)。3年和5年局部控制率分别为98.1%和94.2%；3年和5年总生存率分别为89.0%和86.3%；3年和5年无局部区域复发生存率分别为90.3%和87.1%。单因素分析显示，T分期、淋巴结转移状况、临床分期、病理亚型、病理分化程度、手术方式及放射治疗剂量对预后有统计学意义。多因素分析显示，临床分期和病理分化程度是独立预后因素。结论：腮腺恶性肿瘤手术加术后放疗的综合治疗模式值得推荐，临床分期和病理分化程度是腮腺恶性肿瘤的独立预后因素。

Abstract

Background and purpose: The incidence of parotid gland tumor is highest in the major salivary gland. Malignant parotid gland tumor is of complex pathology features

different clinical manifestation and prognosis. We study the clinical characteristics

treatment and prognostic factors of malignant parotid gland tumor. Methods: From 1989 to 2011

52 patients of primary malignant parotid gland tumor were retrospectively reviewed. All cases were treated with surgery and radiation. Among these cases

23 cases were mucoepidermoid carcinoma

14 cases were adenoidcystic carcinoma

5 cases were acinic cell carcinoma

6 cases were myoepithelial carcinoma

1 case was adenocarcinoma

2 cases were squamous carcinoma and 1 case was undifferentiated carcinoma. Results: The median follow-up was 62 months (14–191 months). The 3-year and 5-year local control rate were 98.1% and 94.2%

respectively. The 3-year and 5-year overall survival rate were 89.0% and 86.3%

respectively. The 3-year and 5-year local regional recurrence-free survival rates were 90.3% and 87.1%

respectively. The univariate analysis revealed that T stage

lymph nodes metastatic status

clinical stage

histological subtype

pathological differentiation

operation pattern and radiotherapy dose were of statistic significance to the prognosis. And multivariate analysis showed that clinical stage and pathological differentiation were the independent prognostic factors of malignant parotid gland tumor. Conclusion: The combination therapy of surgery and radiation in malignant parotid gland tumor is deserved to recommend

and clinical stage and pathological differentiation are the independent prognostic factors.

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