Recent progress on pancreatic cancer stem cells

周竹超; 龚轶一; 倪泉兴

doi:10.3969/j.issn.1007-3969.2013.05.011

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Recent progress on pancreatic cancer stem cells

更新时间：2025-12-31

- Recent progress on pancreatic cancer stem cells
- China Oncology Vol. 23, Issue 5, Pages: 382-388(2013)
- 作者机构：
  
  1. 复旦大学附属华山医院普外科,上海,200040
  2. 复旦大学附属肿瘤医院胰腺外科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2013.05.011
  CLC：
- Published Online：19 November 2014，
  
  Published：2013
- 稿件说明：
移动端阅览
周竹超,龚轶一,倪泉兴. 胰腺肿瘤干细胞研究新进展[J]. 中国癌症杂志, 2013, 23(5): 382-388.

周竹超, 龚轶一, 倪泉兴. Recent progress on pancreatic cancer stem cells[J]. China Oncology, 2013, 23(5): 382-388.
周竹超,龚轶一,倪泉兴. 胰腺肿瘤干细胞研究新进展[J]. 中国癌症杂志, 2013, 23(5): 382-388. DOI： 10.3969/j.issn.1007-3969.2013.05.011.

周竹超, 龚轶一, 倪泉兴. Recent progress on pancreatic cancer stem cells[J]. China Oncology, 2013, 23(5): 382-388. DOI： 10.3969/j.issn.1007-3969.2013.05.011.

摘要

胰腺肿瘤尤其是胰腺导管腺癌的恶性程度高，转移性强，预后差。以往研究表明肿瘤干细胞(cancer stem cells，CSC)在胰腺肿瘤的发生、发展过程中起重要作用，深入了解胰腺肿瘤的发病机制将有助于针对性治疗。在胰腺发育过程中，复杂的信号通路和转录因子决定了其前体细胞分化方向，在胰腺发生恶变过程中，这些因素又参与其中，因而往往可以作为追溯CSC的标志。一些研究也应用特定蛋白来筛选胰腺CSC。现就胰腺CSC的来源、鉴定和靶向治疗进行综述。

Abstract

Pancreatic neoplasm

especially pancreatic ductal adenocarcinoma tends to be with bad prognosis due to higher grade malignancy and metastasis. Formerly researches suggested that cancer stem cells play an important part in the initiation and process of pancreatic cancer

so that

well understanding on the mechanism of pathogenesis will contribute to a direct treatment on it. Complex signal pathways and transcription factors determined the differentiation of precursor cells during the development of pancreas

whereas

also involved in pancreatic malignant changes

which could be used as markers tracking cancer stem cells. Moreover

several special proteins were also employed as tools for pancreatic cancer stem cells screening. In this text

we reviewed origination and identification of pancreatic cancer stem cells

as well as targeted therapy.

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