Advances and pathological diagnostic standard of gastroenteropancreatic neuroendocrine neoplasms

盛伟琪

doi:10.3969/j.issn.1007-3969.2013.06.001

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Advances and pathological diagnostic standard of gastroenteropancreatic neuroendocrine neoplasms

更新时间：2025-12-31

- Advances and pathological diagnostic standard of gastroenteropancreatic neuroendocrine neoplasms
- China Oncology Vol. 23, Issue 6, Pages: 401-407(2013)
- 作者机构：
  
  复旦大学附属肿瘤医院病理科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2013.06.001
  CLC：
- Published Online：13 November 2014，
  
  Published：2013
- 稿件说明：
移动端阅览
盛伟琪. 胃肠胰神经内分泌肿瘤病理诊断的规范和进展[J]. 中国癌症杂志, 2013, 23(6): 401-407.

盛伟琪. Advances and pathological diagnostic standard of gastroenteropancreatic neuroendocrine neoplasms[J]. China Oncology, 2013, 23(6): 401-407.
盛伟琪. 胃肠胰神经内分泌肿瘤病理诊断的规范和进展[J]. 中国癌症杂志, 2013, 23(6): 401-407. DOI： 10.3969/j.issn.1007-3969.2013.06.001.

盛伟琪. Advances and pathological diagnostic standard of gastroenteropancreatic neuroendocrine neoplasms[J]. China Oncology, 2013, 23(6): 401-407. DOI： 10.3969/j.issn.1007-3969.2013.06.001.

摘要

神经内分泌肿瘤(neuroendocrine neoplasm，NEN)是一组起源于肽能神经元和神经内分泌细胞的异质性肿瘤。2010年第4版《世界卫生组织(World Health Organization，WHO)消化系统肿瘤分类》对NEN的命名、分类和分级进行修订和统一，纠正以往NEN诊断名称使用的混乱、规范NEN的病理分类和分级，增加NEN诊断的互认性，为NEN的临床治疗、预后判断提供必要的病理学信息。病理医师在常规病理诊断报告时应当按照一定的步骤要求，结合免疫组织化学染色结果进行准确的诊断、分类和分级，并提供临床分期必需的病理参数。近年来，有关NEN的临床和基础研究结果，使学者们对2010年第四版《WHO消化系统肿瘤分类》的部分内容和分级标准有了新的认识，提出了新观点，一些数据有待于进一步的大样本探讨证实。

Abstract

Neuroendocrine neoplasm (NEN)is a group of heterogeneous tumors originated from the peptidergic neurons and neuroendocrine cells. A revised system of classification

nomenclature and grading of NEN was proposed by the fourth edition of “World Health Organization classification of tumours of the digestive system”in 2010. It apparently contributes to unify the method of classification

put an end of the confusion in nomenclature

standardize the grading system and predict the outcomes more accurately. With the combination of the results by immunohistochemical studies

pathologists should be in accordance with the requirements to make a diagnosis of NEN with accurate classification

grading and the pathological parameters essential to staging. Recently

new advances in NEN study put forward a new view in the classification and grading system that will lead to the updates of the diagnostic system after further studies on a large scale of samples.

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