The E-cadherin promoter -160 C/A polymorphism and nasopharyngeal carcinoma in a Chinese population

金娜; 胡凯; 朱庆尧; 袁超; 王涛

doi:10.3969/j.issn.1007-3969.2013.07.006

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The E-cadherin promoter -160 C/A polymorphism and nasopharyngeal carcinoma in a Chinese population

更新时间：2025-12-31

- The E-cadherin promoter -160 C/A polymorphism and nasopharyngeal carcinoma in a Chinese population
- China Oncology Vol. 23, Issue 7, Pages: 512-518(2013)
- 作者机构：
  
  1. 华中科技大学同济医学院附属协和医院肿瘤中心,湖北,武汉,430022
  2. 广西医科大学第一附属医院肿瘤放疗中心,广西,南宁,530007
  3. 河南省人民医院肿瘤放射治疗科,河南,郑州,450000
  4. 湖北省新华医院ICU,湖北,武汉,430015
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2013.07.006
  CLC：
- Published Online：03 March 2014，
  
  Published：2013
- 稿件说明：
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金娜,胡凯,朱庆尧,袁超,王涛. 上皮钙黏蛋白启动子-160 C/A位点单核苷酸多态性与鼻咽癌的相关性[J]. 中国癌症杂志, 2013, 23(7): 512-518.

金娜, 胡凯, 朱庆尧, et al. The E-cadherin promoter -160 C/A polymorphism and nasopharyngeal carcinoma in a Chinese population[J]. China Oncology, 2013, 23(7): 512-518.
金娜,胡凯,朱庆尧,袁超,王涛. 上皮钙黏蛋白启动子-160 C/A位点单核苷酸多态性与鼻咽癌的相关性[J]. 中国癌症杂志, 2013, 23(7): 512-518. DOI： 10.3969/j.issn.1007-3969.2013.07.006.

金娜, 胡凯, 朱庆尧, et al. The E-cadherin promoter -160 C/A polymorphism and nasopharyngeal carcinoma in a Chinese population[J]. China Oncology, 2013, 23(7): 512-518. DOI： 10.3969/j.issn.1007-3969.2013.07.006.

摘要

背景与目的：上皮钙黏蛋白(E-cadherin，E-cad)作为一种关键的结构蛋白对正常的细胞极性、上皮形态和细胞分化非常重要。最近有研究表明E-cad基因启动子区域-160 C/A基因多态性与鼻咽癌(nasopharyngeal carcinoma，NPC)的易感性有关。本研究旨在评价中国汉族人群中NPC危险性和E-cad基因启动子-160 C/A位点多态性的关系。方法：选取303例明确诊断为NPC的患者为实验组，同时选取318位健康志愿者为对照组。采用TaqMan探针技术检测启动子区域-160 C/A位点的单核苷酸多态性。结果：按性别和年龄调整后，实验组E-cad基因启动子-160 C/A位点A/A基因型危险性显著高于对照组(调整后OR=2.09，95%CI：1.03~4.22，P=0.04)。按性别分层后，女性NPC患者中A/A基因型危险性显著高于对照组(OR=7.57，95%CI：1.57~36.47，P=0.012)。此外，与NPC患者中男性A/A基因型比对，女性A/A基因型具有更高的患病风险(OR=2.66，95%CI：1.14~6.20，P=0.024)。结论：E-cad基因启动子-160 C/A位点的A/A基因型是中国汉族人群患NPC的危险因素之一，尤其对于女性患者尤为显著。

Abstract

Background and purpose: The E-cadherin as a pivotal structural protein is important for cellular polarity and maintainance of normal tissue morphology and cellular differentiation. Recently some study investigated the impact of the C/A genetic polymorphism at -160 from the site of the E-cadherin gene promoter on susceptibility in NPC. To evaluate the association of the E-cadherin gene promoter -160 C/A single nucleotide polymorphism (SNP) and nasopharyngeal carcinoma risk in a Chinese population

we designed a hospital-based case-control study. Methods: Subjects included in this study were 303 patients definitely diagnosed with NPC

and 318 matched healthy controls. We used TaqMan Probe method for analyzing polymorphism. Results: The A/A genotype was associated with increased risk of NPC after being adjusted for age and gender (adjusted OR=2.09

95%CI: 1.03-4.22

P=0.04). When 2 gender groups were analysed respectively

female group with A/A genotypes showed a higher risk (OR=7.57

95%CI: 1.57-36.47

P=0.012). Besides

among NPC patients compared with males A/A genotype

females with A/A genotype had a significant risk(OR=2.66

95%CI: 1.14-6.20

P=0.024). Conclusion: The A/A genotype of E-cadherin promoter -160 C/A might be genetic risk factor for NPC

especially female patients.

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