Advances in the study of deubiquitinating enzymes in cancer research

戴陈新; 郑亚新; 审校

doi:10.3969/j.issn.1007-3969.2013.07.012

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Advances in the study of deubiquitinating enzymes in cancer research

更新时间：2025-12-31

- Advances in the study of deubiquitinating enzymes in cancer research
- China Oncology Vol. 23, Issue 7, Pages: 547-550(2013)
- 作者机构：
  
  同济大学附属东方医院肝脏病科,上海,200120
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2013.07.012
  CLC：
- Published Online：03 March 2014，
  
  Published：2013
- 稿件说明：
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戴陈新1,综述袁健2,郑亚新1,审校. 去泛素化酶与肿瘤发生及发展关系的研究进展[J]. 中国癌症杂志, 2013, 23(7): 547-550.

戴陈新, 郑亚新, 审校. Advances in the study of deubiquitinating enzymes in cancer research[J]. China Oncology, 2013, 23(7): 547-550.
戴陈新1,综述袁健2,郑亚新1,审校. 去泛素化酶与肿瘤发生及发展关系的研究进展[J]. 中国癌症杂志, 2013, 23(7): 547-550. DOI： 10.3969/j.issn.1007-3969.2013.07.012.

戴陈新, 郑亚新, 审校. Advances in the study of deubiquitinating enzymes in cancer research[J]. China Oncology, 2013, 23(7): 547-550. DOI： 10.3969/j.issn.1007-3969.2013.07.012.

摘要

去泛素化酶具有逆转泛素化的作用，其大多数研究还保留在分子生物学领域，在转化医学研究中尚未引起充分的重视。目前研究发现，去泛素化酶的目的蛋白通过各种途径影响肿瘤的发生、发展，如细胞凋亡和自噬、炎性反应和肿瘤的关系、肿瘤缺氧、肿瘤信号通路、细胞周期的调节和DNA损伤等。现就去泛素化酶与肿瘤发生、发展的关系及研究进展作一综述。

Abstract

Deubiquitinating enzymes

reversing protein ubiquitination

most of the researches focused on the field of molecular biology. However

it have not yet attracted enough attention in translational medicine research. In fact

target proteins of deubiquitinating enzymes affect the tumor progression through various ways

for example

cell apoptosis and autophagy

the link between inflammation and cancer

tumor hypoxia

signal transduction

cell cycle regulation and DNA damage. This paper reviewed the research progress on the relations between deubiquitinating enzymes and the correlated factors of tumor.

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