The relationship between chemokines and breast cancer

欧周罗

doi:10.3969/j.issn.1007-3969.2013.08.010

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The relationship between chemokines and breast cancer

更新时间：2025-12-31

- The relationship between chemokines and breast cancer
- China Oncology Vol. 23, Issue 8, Pages: 618-636(2013)
- 作者机构：
  
  复旦大学附属肿瘤医院乳腺癌研究所，复旦大学上海医学院肿瘤学系,上海,20032
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2013.08.010
  CLC：
- Published Online：26 February 2014，
  
  Published：2013
- 稿件说明：
移动端阅览
欧周罗. 趋化因子与乳腺癌[J]. 中国癌症杂志, 2013, 23(8): 618-636.

欧周罗. The relationship between chemokines and breast cancer[J]. China Oncology, 2013, 23(8): 618-636.
欧周罗. 趋化因子与乳腺癌[J]. 中国癌症杂志, 2013, 23(8): 618-636. DOI： 10.3969/j.issn.1007-3969.2013.08.010.

欧周罗. The relationship between chemokines and breast cancer[J]. China Oncology, 2013, 23(8): 618-636. DOI： 10.3969/j.issn.1007-3969.2013.08.010.

摘要

趋化因子参与乳腺癌细胞的生长、血管生成及远处转移过程。然而，近年来单靶点趋化因子受体拮抗剂的临床试验多以失败告终，彰显了肿瘤微环境中趋化因子网络的复杂性，因此基于多向药理学原理确立多靶点调控策略势在必行。多靶点非典型性趋化因子受体(ACR)作为内源性和生理性的调节分子，有可能成为捕获高表达的多种促肿瘤性趋化因子、有效控制乳腺癌的利器。

Abstract

Many chemokines and chemokine receptors

such as CCL2 and CXCR4

participate in the growth

angiogenesis

distal metastasis of breast cancer. However

the recent failures in the clinical trials of some single target antagonists suggest that chemokine network in tumor microenvironment is really complicated. Obviously

multitargets regulation strategy for chemokines is indispensable based on the polypharmacological principle in the future. Atypical chemokine receptors (ACR) as endogenous and physiological regulators

including Duffy antigen receptor for chemokines (DARC)

D6 and ChemoCentryx chemokine receptor (CCX-CKR)

may be the powerful candidates for this purpose.

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