Relationship between MTHFR C677T gene polymorphisms and chemotherapy side effects in advanced non-small cell lung cancer

寇军燕; 洪卫; 洪丹; 苏丹; 娄广媛; 张沂平

doi:10.3969/j.issn.1007-3969.2014.03.007

您当前的位置：

首页 >

文章列表页 >

Relationship between MTHFR C677T gene polymorphisms and chemotherapy side effects in advanced non-small cell lung cancer

更新时间：2025-12-31

- Relationship between MTHFR C677T gene polymorphisms and chemotherapy side effects in advanced non-small cell lung cancer
- China Oncology Vol. 24, Issue 3, Pages: 197-202(2014)
- 作者机构：
  
  1. 杭州市肿瘤医院肿瘤综合科,浙江,杭州
  2. 浙江省肿瘤医院化疗中心十六病区,浙江,杭州
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2014.03.007
  CLC：
- Published Online：01 April 2014，
  
  Published：01 April 2014
- 稿件说明：
移动端阅览
寇军燕,洪卫,洪丹,苏丹,娄广媛,张沂平.

寇军燕, 洪卫, 洪丹, et al. Relationship between MTHFR C677T gene polymorphisms and chemotherapy side effects in advanced non-small cell lung cancer[J]. China Oncology, 2014, 24(3): 197-202.
寇军燕,洪卫,洪丹,苏丹,娄广媛,张沂平. DOI： 10.3969/j.issn.1007-3969.2014.03.007.

寇军燕, 洪卫, 洪丹, et al. Relationship between MTHFR C677T gene polymorphisms and chemotherapy side effects in advanced non-small cell lung cancer[J]. China Oncology, 2014, 24(3): 197-202. DOI： 10.3969/j.issn.1007-3969.2014.03.007.

摘要

背景与目的：亚甲基四氢叶酸还原酶(methylene tetrahydrofolate reductase，MTHFR)是叶酸代谢的关键酶，在DNA甲基化中起重要作用。本研究旨在探讨MTHFR C677T多态性与晚期非小细胞肺癌(nonsmall cell lung cancer，NSCLC)化疗不良反应的关系。方法：收集2007年6月—2009年5月在浙江省肿瘤医院经病理学确诊的晚期NSCLC患者100例。所有患者均接受铂类药物联合吉西他滨的方案化疗。用等位基因特异-PCR技术检测患者MTHFR基因型。结果：100例晚期NSCLC患者中，MTHFR C677T T/T、T/C和C/C基因型频率分别为20%、44%和36%。在血液学不良反应中，C/C基因型血小板减少发生率较T/T、T/C基因型低，差异有统计学意义(P=0.039)。本研究未发现MTHFR各基因型与化疗后恶心、呕吐不良反应相关。结论：MTHFRC677T基因多态性对预测晚期NSCLC含铂类药物方案化疗后不良反应有临床意义。

Abstract

Background and purpose: Methylene tetrahydrofolate reductase (MTHFR) plays an important role in metabolism of folate and DNA methylation. This study aimed to investigate the relationship between methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism and chemotherapy side effects in advanced non-small cell lung cancer (NSCLC) patients. Methods: A total of 100 patients with advanced NSCLC confirmed by pathology were included into this study in Zhejiang Cancer Hospital from Jun. 2007 to May. 2009. All patients received the combined chemotherapy of platinum drug and gemcitabine. MTHFR genotypes were determined by allele-specific-PCR technology. Results: In the 100 cases

genotype frequency of MTHFR C677T T/T

T/C and C/C were 20%

44% and 36%

respectively. Compared with patients of T/T and T/C genotype

patients of C/C genotype were correlated with decreased rate of thrombocytopenia to chemotherapy (P=0.039). No significant differences were observed concerning gastrointestinal toxicity. Conclusion: MTHFR C677T gene polymorphism can be used to predict the adverse reactions to platinum-based chemotherapy in patients with advanced NSCLC.

关键词

Keywords

references

Views

2603

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

A study on prevention and treatment of chemotherapy induced nausea and vomiting in non-small cell lung cancer patients with low-frequency electrical stimulator for antiemesis

BIMcombined with Scribble predicts treatment effect from chemotherapy in advanced non-small cell lung cancer

Efficacy of EGFR-TKI and chemotherapy in advanced non-small cell lung cancer with EGFR-TKI resistence

Chinese expert consensus on whole-process management of chemotherapy-related diarrhea (2025 edition)

Effectiveness and safety analysis of camrelizumab combined with chemotherapy and targeted therapy in patients with recurrent, metastatic, and treatment-naive advanced cervical cancer: a retrospective cohort study

Related Author

Lingling ZHANG

Xiangyi WANG

Xing WEI

Li LIN

Chuanhao TANG

Jun LIANG

张龙富

姚家美

Related Institution

Department of Oncology, Peking University International Hospital

上海市徐汇区中心医院呼吸科

复旦大学附属中山医院呼吸科

复旦大学附属中山医院病理科

南通市肿瘤医院肿瘤内科

AI问答

⁰