Study of CCL28 expression in breast cancer

龚迪和; 丁克峰

doi:10.3969/j.issn.1007-3969.2014.04.011

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Study of CCL28 expression in breast cancer

更新时间：2025-12-31

- Study of CCL28 expression in breast cancer
- China Oncology Vol. 24, Issue 4, Pages: 304-309(2014)
- 作者机构：
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- DOI：10.3969/j.issn.1007-3969.2014.04.011
  CLC：
- Published Online：06 May 2014，
  
  Published：06 May 2014
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龚迪和,丁克峰. 趋化因子CCL28在乳腺癌中的表达及意义[J]. 中国癌症杂志, 2014, 24(4): 304-309.

龚迪和, 丁克峰. Study of CCL28 expression in breast cancer[J]. China Oncology, 2014, 24(4): 304-309.
龚迪和,丁克峰. 趋化因子CCL28在乳腺癌中的表达及意义[J]. 中国癌症杂志, 2014, 24(4): 304-309. DOI： 10.3969/j.issn.1007-3969.2014.04.011.

龚迪和, 丁克峰. Study of CCL28 expression in breast cancer[J]. China Oncology, 2014, 24(4): 304-309. DOI： 10.3969/j.issn.1007-3969.2014.04.011.

摘要

背景与目的：目前已知趋化因子在乳腺癌的发生、发展中扮演着重要的角色，但对CCL28在乳腺癌的功能报道较少，本研究旨在探讨趋化因子CCL28在人乳腺癌中的表达情况，并分析其与乳腺癌相关临床病理指标之间的关系。方法：采用免疫组织化学方法检测趋化因子CCL28在150例乳腺癌、相应癌旁正常乳腺组织的表达差异情况；分析乳腺癌中CCL28表达与患者年龄、临床分期、肿瘤直径、淋巴结转移状况、雌激素受体(estrogen receptor，ER)、孕激素受体(progesterone receptor，PR)、人表皮生长因子受体-2(humanepidermal growth factor receptor-2，HER-2)等临床病理指标的相关性。结果：①CCL28在乳腺癌组及癌旁正常乳腺组中均有表达，在乳腺癌组中CCL28的阳性表达率为54.6%，在癌旁正常乳腺组中的阳性表达率为9.3%；CCL28在乳腺癌组的表达明显高于癌旁正常乳腺组，差异有统计学意义(P＜0.001)。②CCL28的表达与患者的年龄、肿瘤直径、临床分期、淋巴结转移与否、ER、PR及HER-2的表达等临床病理指标无关(P＞0.05)。结论：CCL28在乳腺癌中呈现高表达而在癌旁正常乳腺组织则表达较少，CCL28可能与乳腺癌发生、发展有关。CCL28在乳腺癌中表达的高低与发生淋巴结转移无明显的相关性，CCL28能否作为预测淋巴结转移的指标有待于进一步的研究。

Abstract

Background and purpose: Chemokines play an important role in breast cancer occurrence and development. However

little about the function of CCL28 in breast cancer is reported. This study was designed to observe and study the expression of chemokine CCL28 in breast cancer

and analyze their association with pathological features of breast cancer. Methods: Expressions of chemokine CCL28 in 150 breast cancer patients were determined by IHC(immunohistochemistry) technique. The corresponding normal breast tissues in paraneoplastic were also detected. The level of CCL28 expression in 150 breast cancer was analyzed whether it was associated with age

cTNM stage

tumor diameter

axillary lymph node status

ER status

PR status and HER-2 status. Results: ①CCL28 was highly expressed in both breast cancer and normal breast tissues in paraneoplastic. The positive expression rate of CCL28 in breast cancer was 54.6% and the positive expression rate of CCL28 in normal paraneoplastic breast tissues was 9.3%. Expression of CCL28 in breast cancer was significantly higher than that in normal paraneoplastic breast tissues

there was statistically significance between the two groups(P0.001). ②The expression of CCL28 was not associated with age

cTNM stage

tumor size

axillary lymph node

PR and HER-2 status(P0.05). Conclusion: The level of CCL28 expression showed significantly difference between breast cancer and paraneoplastic normal breast tissues. In conclusion

CCL28 may be correlated with breast cancer carcinogenesis and evolvement. The level of CCL28 expression was not significantly correlated with lymph node metastasis. If CCL28 may be a factor to predict lymph node metastasis in breast cancer is worth further studying.

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