Progression of adjuvant radiotherapy upon breast cancer immunity

王小方; 郭小毛

doi:10.3969/j.issn.1007-3969.2014.05.012

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Progression of adjuvant radiotherapy upon breast cancer immunity

更新时间：2025-12-31

- Progression of adjuvant radiotherapy upon breast cancer immunity
- China Oncology Vol. 24, Issue 5, Pages: 392-396(2014)
- 作者机构：
  
  复旦大学附属肿瘤医院放疗科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2014.05.012
  CLC：
- Published Online：26 May 2014，
  
  Published：26 May 2014
- 稿件说明：
移动端阅览
王小方, 郭小毛. 乳腺癌辅助放疗对抗肿瘤免疫影响的研究进展[J]. 中国癌症杂志, 2014, 24(5): 392-396.

王小方, 郭小毛. Progression of adjuvant radiotherapy upon breast cancer immunity[J]. China Oncology, 2014, 24(5): 392-396.
王小方, 郭小毛. 乳腺癌辅助放疗对抗肿瘤免疫影响的研究进展[J]. 中国癌症杂志, 2014, 24(5): 392-396. DOI： 10.3969/j.issn.1007-3969.2014.05.012.

王小方, 郭小毛. Progression of adjuvant radiotherapy upon breast cancer immunity[J]. China Oncology, 2014, 24(5): 392-396. DOI： 10.3969/j.issn.1007-3969.2014.05.012.

摘要

免疫是机体的基本防御屏障，与乳腺癌的发生、发展、治疗及预后密切相关。辅助放疗是乳腺癌综合治疗的重要组成部分。传统观点认为放疗可直接破坏机体免疫细胞，进而抑制机体免疫的抗肿瘤效果。而近期研究表明，放疗可刺激免疫系统产生一系列积极反应，有利于肿瘤杀伤过程中抗原的加工、提呈、识别及肿瘤的最终杀伤。临床方面，放疗联合多种免疫靶向治疗相继进入临床试验阶段。本文将对乳腺癌放疗对抗肿瘤免疫影响的研究发展及现状进行介绍。

Abstract

Immunity is the basic defense barrier for body

and also closely related to the development

progression

treatment and prognosis of breast cancer. Adjuvant radiotherapy plays an important role in the multidisciplinary treatment of breast cancer. It has long been believed that radiotherapy was immunosuppressive because it could destroy the body’s immune cells directly. While recent studies have shown that radiotherapy can stimulate the host immune system in the antitumor process

including antigen processing

presentation

recognition

and eventually tumor-cell killing. In the clinical aspect

a variety of immune targeted therapies

combined with radiotherapy

have entered clinical trials. The article reviewed research progress and status of the influence of breast cancer adjuvant radiotherapy on antitumor immunity.

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Related Institution

Department of Radiotherapy, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University

Department of Breast Cancer Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences

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