Analysis of prognostic factors and index model in patients with brain metastases after wholebrain radiotherapy

朱虹; 吕博; 李云海; 王洪林; 赵森

doi:10.3969/j.issn.1007-3969.2014.06.010

您当前的位置：

首页 >

文章列表页 >

Analysis of prognostic factors and index model in patients with brain metastases after wholebrain radiotherapy

更新时间：2025-12-31

- Analysis of prognostic factors and index model in patients with brain metastases after wholebrain radiotherapy
- China Oncology Vol. 24, Issue 6, Pages: 457-462(2014)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院闵行分院放疗科,上海,200240
  2. 复旦大学附属肿瘤医院放疗科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2014.06.010
  CLC：
- Published Online：29 July 2014，
  
  Published：29 July 2014
- 稿件说明：
移动端阅览
朱虹,吕博,李云海,王洪林,赵森. 脑转移瘤放射治疗的预后因素分析及预后模型的建立[J]. 中国癌症杂志, 2014, 24(6): 457-462.

朱虹, 吕博, 李云海, et al. Analysis of prognostic factors and index model in patients with brain metastases after wholebrain radiotherapy[J]. China Oncology, 2014, 24(6): 457-462.
朱虹,吕博,李云海,王洪林,赵森. 脑转移瘤放射治疗的预后因素分析及预后模型的建立[J]. 中国癌症杂志, 2014, 24(6): 457-462. DOI： 10.3969/j.issn.1007-3969.2014.06.010.

朱虹, 吕博, 李云海, et al. Analysis of prognostic factors and index model in patients with brain metastases after wholebrain radiotherapy[J]. China Oncology, 2014, 24(6): 457-462. DOI： 10.3969/j.issn.1007-3969.2014.06.010.

摘要

背景与目的：放射治疗是大多数脑转移瘤最主要的治疗手段，而预后却受多种因素的影响。本研究探讨影响肿瘤脑转移患者放射治疗生存期的预后因素并建立预后指数模型。方法：选择2008年1月—2011年7月符合入组条件接受放射治疗的脑转移患者140例，对各影响因素行单因素分析，差异有统计学意义的因素再行多因素分析，筛选出与预后最为相关的因素，并计算预后指数(prognostic index，PI)。同时，评估递归分区分析(recursive partitioning analysis classes，RPA)、脑转移基本评分(basic score for brain metastases，BS-BM)及等级预后评估标准(the graded prognostic assessment index，GPA)是否与预后相关。结果：全组中位生存时间为222 d。单因素检验提示卡氏评分(karnofsky performance score，KPS)、脑转移数目、中枢外转移、原发灶控制、放疗剂量、血红蛋白与预后相关；多因素分析筛选出KPS(P=0.002、Wald=9.700)、中枢外转移(P=0.018，Wald=5.604)、原发灶控制(P=0.001、Wald=10.212)3个因素影响总生存期。Log-rank检验提示，3种评分模式均与预后相关，而对于本组患者的3、6个月生存概率的预测，PI优于其他评分模式。结论：PI预后指数模型和3种预后指数均能反映预后，但PI更佳。

Abstract

Background and purpose: Radiation therapy is still the most primary treatment of brain metastases

and prognosis is affected by many factors. The aim of this study was to identify the prognostic factors and to establish a prognostic index model in patients with brain metastases after whole-brain radiotherapy (WBRT). Methods: We reviewed the clinical date of 140 patients with brain metastases radiotherapy in our hospital from Jan. 2008 to Jul. 2011. The significance of prognostic variables in the survival was resulted from both univariate analysis and multivariate analysis. The prognostic index (PI) was established based on Cox regression analysis and subgrouping values. It was assessed whether recursive partitioning analysis classes (RPA)

basic score for brain metastases (BSBM) and the graded prognostic assessment index (GPA) were related to prognosis. Results: The median survival time was 222 days. The univariate analysis showed that the independent prognostic factors were KPS performance status

number of brain metastases

presence of extracranial metastases

primary tumor status

radiation dose

hemoglobin. The multivariate analysis showed that KPS performance status (P=0.002

Wald=9.700)

presence of extracranial metastases (P=0.018

Wald=5.604) and primary tumor status (P=0.001

Wald=10.212) were significantly correlated with overall survival. RPA

BS-BM and GPA were closely related to their prognosis by Log-rank test. In predicting 3 months and 6 months of survival for patients

PI was better than other modes. Conclusion: Our data suggest that the 3 indexes RPA

BS-BM and GPA are valid prognostic index models

but PI model is better.

关键词

Keywords

references

Views

2577

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinicopathologic features of SMARCA4-deficient pulmonary malignant tumor with an emphasis on the prognosis

Treatment strategies and prognostic analysis of 87 patients with salivary duct carcinoma: a retrospective cohort study

Impact of radiation-induced lymphopenia on prognosis in patients with limited-stage small cell lung cancer: a cohort study

MITF expression in acral melanoma tissues and its association with clinical, pathological characteristics and prognosis

A cohort study of prognostic value of ¹⁸F-FDG PET/CT metabolic parameters in patients with diffuse large B-cell lymphoma treated with CAR-T

Related Author

CHANG Kesheng

SHAO Jin

ZHANG Qi

LIU Yifei

Ximei ZHANG

Yixuan ZHOU

Yan ZHAO

Xuan ZHOU

Related Institution

Department of Pathology, Wuxi Second People’s Hospital

Department of Pathology, Affiliated Hospital of Nantong University

Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Malignant Tumors

Tianjin Clinical Research Center for Malignant Tumors

Stomatological Clinical College of Tianjin Medical University

AI问答

⁰