Recent advances in cancer-associated circulating cell-free nucleic acids

邢星; 刘勇; 孙勇; 周鑫; 胡超苏

doi:10.3969/j.issn.1007-3969.2014.06.012

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Recent advances in cancer-associated circulating cell-free nucleic acids

更新时间：2025-12-31

- Recent advances in cancer-associated circulating cell-free nucleic acids
- China Oncology Vol. 24, Issue 6, Pages: 469-475(2014)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院放疗科，复旦大学上海医学院肿瘤学系,上海,200032
  2. 复旦大学附属肿瘤医院肿瘤研究所，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2014.06.012
  CLC：
- Published Online：29 July 2014，
  
  Published：29 July 2014
- 稿件说明：
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邢星,刘勇,孙勇,周鑫,胡超苏. 肿瘤相关循环游离核酸的研究进展[J]. 中国癌症杂志, 2014, 24(6): 469-475.

邢星, 刘勇, 孙勇, et al. Recent advances in cancer-associated circulating cell-free nucleic acids[J]. China Oncology, 2014, 24(6): 469-475.
邢星,刘勇,孙勇,周鑫,胡超苏. 肿瘤相关循环游离核酸的研究进展[J]. 中国癌症杂志, 2014, 24(6): 469-475. DOI： 10.3969/j.issn.1007-3969.2014.06.012.

邢星, 刘勇, 孙勇, et al. Recent advances in cancer-associated circulating cell-free nucleic acids[J]. China Oncology, 2014, 24(6): 469-475. DOI： 10.3969/j.issn.1007-3969.2014.06.012.

摘要

循环游离核酸是指存在于人体血液循环中，游离于细胞外的微量内源性或外源性核酸片段。肿瘤患者的血液中游离核酸的含量明显高于健康人群，并具有与肿瘤的发生、发展相关的特征性改变，如基因突变、甲基化、杂合性丢失、片段完整性改变、microRNA的异常表达等。对血液中游离核酸的定性与定量检测，在肿瘤的筛查、诊断、个体化治疗方案的制定、病情的监测以及预后评价中均有潜在的价值。

Abstract

Circulating cell-free nucleic acids are defined as extracellular DNAs or RNAs in blood with physiological or pathological origins. Previous studies showed that the concentration of cell-free nucleic acids in the blood of cancer patients is significantly higher than in healthy people. Further studies showed that the genetic and epigenetic alterations of circulating cell-free nucleic acids are relevant to cancer development and progression

including mutation

hypermethylation

loss of heterozygosity

change of integrity

and abnormal expression of microRNAs. Detection of circulating cell-free nucleic acids shows promising potential in cancer screening

diagnosis

personalized treatment

and prognosis.

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