Application of whole body 18F-FDG PET/CT plus additional delayed pelvic scan after oral hydration in the diagnosis of the bladder malignant lesions

程竞仪; 杨忠毅; 张勇平; 王新村; 潘玲玲; 朱一平; 章英剑

doi:10.3969/j.issn.1007-3969.2014.07.012

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Application of whole body 18F-FDG PET/CT plus additional delayed pelvic scan after oral hydration in the diagnosis of the bladder malignant lesions

更新时间：2025-12-31

- Application of whole body 18F-FDG PET/CT plus additional delayed pelvic scan after oral hydration in the diagnosis of the bladder malignant lesions
- China Oncology Vol. 24, Issue 7, Pages: 540-544(2014)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院核医学科，复旦大学上海医学院肿瘤学系,上海,200032
  2. 复旦大学附属肿瘤医院泌尿外科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2014.07.012
  CLC：
- Published Online：29 July 2014，
  
  Published：29 July 2014
- 稿件说明：
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程竞仪,杨忠毅,张勇平,王新村,潘玲玲,朱一平,章英剑.

程竞仪, 杨忠毅, 张勇平, et al. Application of whole body 18F-FDG PET/CT plus additional delayed pelvic scan after oral hydration in the diagnosis of the bladder malignant lesions[J]. China Oncology, 2014, 24(7): 540-544.
程竞仪,杨忠毅,张勇平,王新村,潘玲玲,朱一平,章英剑. DOI： 10.3969/j.issn.1007-3969.2014.07.012.

程竞仪, 杨忠毅, 张勇平, et al. Application of whole body 18F-FDG PET/CT plus additional delayed pelvic scan after oral hydration in the diagnosis of the bladder malignant lesions[J]. China Oncology, 2014, 24(7): 540-544. DOI： 10.3969/j.issn.1007-3969.2014.07.012.

摘要

背景与目的：

F-FDG经过由尿液排泄，膀胱中尿液的高放射性影响了膀胱病灶的检出，本研究介绍一种

F-FDG PET/CT检查中提高膀胱恶性病灶检出率的简便方法——“反复排尿再充盈法”，即：

F-FDG注射后反复饮水-排尿、最后憋尿检查。方法：回顾性分析了48例(35例原发、13例非原发)膀胱恶性肿瘤患者

F-FDG常规显像后，通过反复饮水-排尿、再憋尿进行盆腔延迟显像的结果。结果：89%的患者(43/48)在首次延迟显像时，尿液SUV

max

(SUV最大值)从33.14(9～66.80)降至3.23(1.35～5.65)，差异有统计学意义，(t=8.703

P0.01)，2次显像的平均间隔时间为2 h，而膀胱病灶的SUVmax为2.8～25.0。该延迟显像方法对膀胱癌诊断灵敏度为90.5%(19/21)、特异度为81.5%(22/27)、准确性为85.4%(41/48)。结论：反复饮水-排尿、最后憋尿情况下的盆腔延迟显像能在保持膀胱壁解剖对比的同时，有效降低膀胱尿液放射性本底、增加病灶靶/本比，进而增加膀胱癌灶检出率，且简单易行，值得推广。

Abstract

Background and purpose:

F-FDG has been considered to be of limited value for the detection of bladder lesions because of interference by the

F-FDG excreted in urine. Delayed pelvic images with “diluted and filled bladder” use a method of

F-FDG PET/CT with delayed images after oral hydration so as to increase the detection rate of 18F-fluorodeoxyglucose(FDG) PET/CT imaging for the lesions of bladder. Methods: 48 patients with bladder lesions(35 patients with bladder primary tumor and 13 patients with metastatic tumor) underwent

F-FDG PET/CT

detection and were required oral hydration of 1200-1800 mL water

urination frequently

holding urine when the more scan began. Lesions confirmed by histopathology

MRI

CT or clinical follow-up at least 1 year. Results: 89%(43/48) of patients were obtained good clearance and the urine SUV

max

declined from 33.14(9-66.80)to 3.23(1.35-5.65) significantly and the statistical difference was significant (t=8.703

P0.01). The interval time between two scan was 2 h approximately. At the same time

the SUV

max

of bladder lesion was 2.8-25.0. Detection sensitivity

specificity and accuracy were 90.47%(19/21)

81.48%(22/27)and 85.41%(41/48)

respectively. Conclusion:

F-FDG activity in the bladder significantly decreased in most patients with “diluted and filled bladder”. The PET/CT scan can highly detect lesions of bladder tissues. Our method with high accuracy and better endurance could be applied to detect the lesions in bladder.

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