The clinical value of liquid tumor biomarker detection for breast cancer

doi:10.3969/j.issn.1007-3969.2014.08.014

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The clinical value of liquid tumor biomarker detection for breast cancer

更新时间：2025-12-31

- The clinical value of liquid tumor biomarker detection for breast cancer
- China Oncology Vol. 24, Issue 8, Pages: 636-640(2014)
- 作者机构：
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- DOI：10.3969/j.issn.1007-3969.2014.08.014
  CLC：
- Published Online：07 November 2014，
  
  Published：07 November 2014
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周金妹综述，江泽飞审校. 液体肿瘤生物指标检测对乳腺癌患者的临床价值[J]. 中国癌症杂志, 2014, 24(8): 636-640.

The clinical value of liquid tumor biomarker detection for breast cancer[J]. China Oncology, 2014, 24(8): 636-640.
周金妹综述，江泽飞审校. 液体肿瘤生物指标检测对乳腺癌患者的临床价值[J]. 中国癌症杂志, 2014, 24(8): 636-640. DOI： 10.3969/j.issn.1007-3969.2014.08.014.

The clinical value of liquid tumor biomarker detection for breast cancer[J]. China Oncology, 2014, 24(8): 636-640. DOI： 10.3969/j.issn.1007-3969.2014.08.014.

摘要

循环肿瘤标志物在乳腺癌中的应用受到越来越多的关注，研究水平已从蛋白质水平深入到基因水平，相应的检测指标则从传统的肿瘤标志物扩展到相对特异的HER-2蛋白质细胞外段、循环肿瘤细胞、循环肿瘤DNA及循环RNA等。作为“液体检测”，循环肿瘤标志物的检测因其实时动态、操作简便、可重复性好等优势，被广泛应用于协助早期诊断、判断预后、预测疗效、监测疾病复发及病情变化等方面。对循环肿瘤标志物的深入研究，有助于实现患者的个体化治疗。

Abstract

Circulating tumor markers have been paid more attention in the application of the treatment for breast cancer

the level of which has extended from protein to gene

including traditional tumor markers

HER-2 extracellular domain

circulating tumor cells

circulating tumor DNA (ctDNA)

circulating RNA (ctRNA) and so on. As “liquid detection”

the detection of circulating tumor markers with real-time dynamic

easy operation

good reproducibility and other advantages are widely used in aiding early diagnosis

determining prognosis

prospectively predicting response or resistance to specific therapies

surveillance after primary surgery

and monitoring therapy in patients with advanced disease

The further study of circulating tumor markers may contribute to patient’s individual treatment.

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Related Author

叶　青

江泽飞

李蕾

The Society of Breast Cancer China Anti-Cancer Association

Breast Oncology Group of the Oncology Branch of the Chinese Medical Association

LU Ye

ZHANG Wenxiang

KONG Xiangyi

Related Institution

军事医学科学院附属医院乳腺肿瘤科

Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital& Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

Department of Cancer Prevention, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

Shanghai Engineering Research Center of Artificial Intelligence Technology for Tumor Diseases

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