Expression of TNFAIP3 gene in radiotherapy of nasopharyngeal carcinoma

邓香群; 叶旭

doi:10.3969/j.issn.1007-3969.2014.11.004

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Expression of TNFAIP3 gene in radiotherapy of nasopharyngeal carcinoma

更新时间：2025-12-31

- Expression of TNFAIP3 gene in radiotherapy of nasopharyngeal carcinoma
- China Oncology Vol. 24, Issue 11, Pages: 820-823(2014)
- 作者机构：
  
  1. 湖南邵阳医学高等专科学校组织学与胚胎学教研室,湖南,邵阳,422000
  2. 湖南省肿瘤医院核医学科,湖南,长沙,410013
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2014.11.004
  CLC：
- Published Online：05 May 2015，
  
  Published：05 May 2014
- 稿件说明：
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邓香群,叶旭.

邓香群, 叶旭. Expression of TNFAIP3 gene in radiotherapy of nasopharyngeal carcinoma[J]. China Oncology, 2014, 24(11): 820-823.
邓香群,叶旭. DOI： 10.3969/j.issn.1007-3969.2014.11.004.

邓香群, 叶旭. Expression of TNFAIP3 gene in radiotherapy of nasopharyngeal carcinoma[J]. China Oncology, 2014, 24(11): 820-823. DOI： 10.3969/j.issn.1007-3969.2014.11.004.

摘要

背景与目的：鼻咽癌多对放射治疗敏感，研究鼻咽癌放疗抗拒具有重要意义。本研究旨在探讨肿瘤坏死因子α诱导蛋白3(tumor necrosis factor alpha induced protein 3，TNFAIP3)在经放射治疗的鼻咽癌中的表达，分析其在放疗敏感及放疗抗拒的鼻咽癌中表达的差异，与放疗抗拒发生、发展的关系。方法：采用TNFAIP3多点标记的地高辛探针原位杂交方法检测TNFAIP3 mRNA在放疗敏感及放疗抗拒的鼻咽癌中的表达。结果：TNFAIP3 mRNA中度及强阳性表达率在放疗敏感及放疗抗拒的鼻咽癌中的表达率分别为15.00%和45.00%，差异有统计学意义(χ2=5.274，P=0.0216)。在放疗抗拒的鼻咽癌中，TNFAIP3 mRNA中度及强阳性表达率与TNM分期呈正相关，Ⅲ~Ⅳ期TNFAIP3 mRNA中度及强阳性表达率为48.28%，I~Ⅱ期表达率为36.36%，差异有统计学意义(χ2=33.240，P＜0.005)；在有、无远处转移中的表达率分别为81.81%和31.03%，差异有统计学意义(χ2=6.385，P=0.011 5)。结论：TNFAIP3虽具有抗肿瘤效应，但参与了放疗抗拒的鼻咽癌的发生、发展。

Abstract

Background and purpose: Nasopharyngeal carcinoma is sensitive with radiotherapy

and it is of great significance to study the resistance mechanism. This study aimed to analyze the expression of TNFAIP3 in the radiotherapy of nasopharyngeal carcinoma

the difference between radiosensitivity and radioresistance

the relationship with the occurrence and development of radioresistance. Methods: Detection of TNFAIP3 mRNA expression was carried out by TNFAIP3 multi-point labeled DIG probe in situ hybridization. Results: In radiosensitivity and radioresistance of nasopharyngeal carcinoma

the moderately and strongly positive TNFAIP3 mRNA expression rates were 15% and 45%

(χ2=5.274

P=0.021 6)

there were statistical significance. In the radioresistat nasopharyngeal carcinoma

TNFAIP3 mRNA moderately and strongly positive expression was positively correlated with TNM stage. In the degree of Ⅲ-Ⅳ tumor

it had moderately and strongly positive expression rate of 48.28%.In the degree of Ⅰ-Ⅱ tumor

it had moderately and strongly positive expression rate of 36.36% (χ2=33.240

P0.005); The expression rates in distant metastasis and no distant metastasis were 81.81% and 31.03% (χ2=6.385

P=0.011 5)

the difference had statistical significance. Conclusion: TNFAIP3 has antitumor effect

and it is correlated with the occurrence and development of radioresistant in nasopharyngeal carcinoma.

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