The related mechanism of radiotherapy in triple-negative breast cancer

李冰馨; 傅深

doi:10.3969/j.issn.1007-3969.2014.11.012

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The related mechanism of radiotherapy in triple-negative breast cancer

更新时间：2025-12-31

- The related mechanism of radiotherapy in triple-negative breast cancer
- China Oncology Vol. 24, Issue 11, Pages: 865-870(2014)
- 作者机构：
  
  1. 上海交通大学附属第六人民医院肿瘤放疗科,上海,200233
  2. 上海市质子重离子医院放射治疗科,上海,201321
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2014.11.012
  CLC：
- Published Online：05 May 2015，
  
  Published：05 May 2014
- 稿件说明：
移动端阅览
李冰馨,傅深. 三阴性乳腺癌放射治疗相关机制的研究进展[J]. 中国癌症杂志, 2014, 24(11): 865-870.

李冰馨, 傅深. The related mechanism of radiotherapy in triple-negative breast cancer[J]. China Oncology, 2014, 24(11): 865-870.
李冰馨,傅深. 三阴性乳腺癌放射治疗相关机制的研究进展[J]. 中国癌症杂志, 2014, 24(11): 865-870. DOI： 10.3969/j.issn.1007-3969.2014.11.012.

李冰馨, 傅深. The related mechanism of radiotherapy in triple-negative breast cancer[J]. China Oncology, 2014, 24(11): 865-870. DOI： 10.3969/j.issn.1007-3969.2014.11.012.

摘要

放射治疗是乳腺癌局部治疗的主要手段之一。三阴性乳腺癌(triple-negative breast cancer，TNBC)作为乳腺癌分子亚型的一个分型，其分子及生物学行为具有多方面特殊性，并存在多个分子靶点的异常，这些异常分子靶点可通过不同机制影响肿瘤对电离辐射的反应，从而调节三阴性乳腺癌的放疗敏感性。现就TNBC的放射治疗及其放疗敏感性相关分子靶点的研究新进展予以综述。

Abstract

Radiotherapy is one of the main means of local treatment of breast cancer. Triple negative breast cancer (TNBC) as a molecular subtypes of breast cancer

its biological behavior is special and existing multiple molecular targets

these molecular targets influence the response of ionization radiation through different mechanisms and regulate radiotherapy sensitivity of TNBC This article reviewed the recent advances in radiotherapy and radiosensitivity related molecular targets of TNBC.

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