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上海交通大学附属第六人民医院肿瘤放疗科,上海,200233
Published Online:07 May 2015,
Published:07 May 2014
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邵雨卉,付杰. 头颈部肿瘤自适应放疗的研究进展[J]. 中国癌症杂志, 2014, 24(12): 951-955.
邵雨卉, 付杰. Progress in research of adaptive radiation therapy for head and neck cancer[J]. China Oncology, 2014, 24(12): 951-955.
邵雨卉,付杰. 头颈部肿瘤自适应放疗的研究进展[J]. 中国癌症杂志, 2014, 24(12): 951-955. DOI: 10.3969/j.issn.1007-3969.2014.12.012.
邵雨卉, 付杰. Progress in research of adaptive radiation therapy for head and neck cancer[J]. China Oncology, 2014, 24(12): 951-955. DOI: 10.3969/j.issn.1007-3969.2014.12.012.
调强放射治疗(intensity-modulated radiation therapy,IMRT)是头颈部恶性肿瘤的重要治疗方法之一。但在IMRT过程中,摆位误差、解剖结构的移位及变形、肿瘤退缩或进展及形状改变等,可导致靶区和危及器官的照射剂量和体积出现“偏差”,影响IMRT的精确性。图像引导的放射治疗(image-guidedradiotherapy,IGRT)可部分纠正摆位误差,从而提高放疗精度,但不能解决非刚性误差以及解剖结构变化带来的剂量差异。自适应放射治疗(adaptive radiation therapy,ART)是在IMRT和IGRT基础上出现的新型放疗技术,能修正IMRT和IGRT靶区和危及器官的偏差。通过患者图像、剂量等反馈信息对原治疗计划重新优化和调整,这是一种基于反馈控制理论的治疗策略。其目的是使放射治疗更加精确化、个体化。
Intensity-modulated radiation therapy (IMRT) is one of the most important techniques for the treatment of head and neck cancers. During IMRT
the accuracy of radiation dose delivery is limited by errors in patient treatment positioning
inter-treatment
and intra-treatment variation of organ position
size
and shape. Image-guided radiation therapy (IGRT) may partly correct these errors and further improve the radiation dose delivery. However
the dose deviation caused by internal organ motion or non-rigid motion cannot be simply solved by IGRT technique. Nowadays
adaptive radiation therapy (ART) has been introduced to minimize the negative effects of treatment position uncertainty which normally exist in either IMRT or IGRT
and to compensate the target coverage and clinical outcome. Based on the patient’s pre-treatment images and relative information such as dose deviation
ART may provide a better strategy for online treatment. Under the help of ART technique
radiotherapy can be more accurate and more personalized.
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