The clinical significance of DJ-1 over expression in pancreatic neuroendocrine neoplasms

杨立新; 张丽娜; 张天彪

doi:10.3969/j.issn.1007-3969.2015.02.006

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The clinical significance of DJ-1 over expression in pancreatic neuroendocrine neoplasms

更新时间：2025-12-31

- The clinical significance of DJ-1 over expression in pancreatic neuroendocrine neoplasms
- China Oncology Vol. 25, Issue 2, Pages: 112-118(2015)
- 作者机构：
  
  1. 沈阳医学院附属中心医院内分泌科,辽宁,沈阳,110024
  2. 沈阳医学院附属中心医院重症医学科,辽宁,沈阳,110024
  3. 中国医科大学生物化学与分子生物学教研室,辽宁,沈阳,110001
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2015.02.006
  CLC：
- Published Online：13 May 2015，
  
  Published：13 May 2015
- 稿件说明：
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杨立新,张丽娜,张天彪. 胰腺神经内分泌肿瘤中DJ-1蛋白高表达的临床意义[J]. 中国癌症杂志, 2015, 25(2): 112-118.

杨立新, 张丽娜, 张天彪. The clinical significance of DJ-1 over expression in pancreatic neuroendocrine neoplasms[J]. China Oncology, 2015, 25(2): 112-118.
杨立新,张丽娜,张天彪. 胰腺神经内分泌肿瘤中DJ-1蛋白高表达的临床意义[J]. 中国癌症杂志, 2015, 25(2): 112-118. DOI： 10.3969/j.issn.1007-3969.2015.02.006.

杨立新, 张丽娜, 张天彪. The clinical significance of DJ-1 over expression in pancreatic neuroendocrine neoplasms[J]. China Oncology, 2015, 25(2): 112-118. DOI： 10.3969/j.issn.1007-3969.2015.02.006.

摘要

背景与目的：胰腺神经内分泌肿瘤(pancreatic neuroendocrine neoplasms，PNENs)症状复杂多样，易发生误诊和漏诊。本研究旨在探讨PNENs中DJ-1蛋白表达水平及其在病程进展及预后中的临床意义。方法：采用ELISA法检测16例PNENs及25例健康人血清中DJ-1蛋白的水平，采用免疫组织化学法检测了78例PNENs病理组织中DJ-1蛋白的表达情况。结果：PNENs患者血清中DJ-1蛋白水平显著高于健康人(36.19±6.71vs 24.68±5.94 ng/mL；P＜0.001)；53.8%的PNENs组织中DJ-1蛋白呈阳性表达(42/78)；PNENs组织中DJ-1表达水平与淋巴结转移(P=0.033)、远处转移(P=0.017)、TNM分期(P=0.012)、以及病理分级(P=0.049)呈显著正相关；作为非独立风险因素，DJ-1阳性表达与PNENs患者OS(P=0.003)及DFS(P=0.018)缩短均显著相关。结论：PNENs存在DJ-1蛋白高表达，且与肿瘤的侵袭转移、病程进展及不良预后相关。

Abstract

Background and purpose: The symptoms of pancreatic neuroendocrine neoplasms (PNENs) are complicated

that might lead to misdiagnosis. This study aimed to detect the expression level of DJ-1 in PNENs and explore the clinical significance of DJ-1 in PNENs. Methods: DJ-1 protien levels in the serum of 16 cases of PNENs patients and 25 cases of healthy persons were detected by ELISA analysis; The expressions of DJ-1 in 78 cases of PNENs tissues were detected by immunohistochemical staining. Results: The DJ-1 level in the serum of PNENs patients was significantly higher than healthy persons (36.19±6.71 vs 24.68±5.94 ng/mL; P0.001); 53.8% (42/78) cases of PNENs tissues showed DJ-1 positive staining; DJ-1 expression level in PNENs tissues had significantly positive correlation with lymph node metastasis (P=0.033)

distant metastasis (P=0.017)

TNM stage (P=0.012)

and pathology grade (P=0.049); As a dependent risk factor

DJ-1 expression was significantly associated with shorter OS (P=0.003) and DFS (P=0.018) of PNENs patients. Conclusion: High expression of DJ-1 protein correlated with invasion and metastasis

disease progression

and poor prognosis in PNEN.

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