Dysphagia after radiotherapy: esophageal barium fluoroscopy examination of swallowing in nasopharyngeal carcinoma patients

林冯杰; 徐鹭英; 陈惠琴

doi:10.3969/j.issn.1007-3969.2015.05.009

您当前的位置：

首页 >

文章列表页 >

Dysphagia after radiotherapy: esophageal barium fluoroscopy examination of swallowing in nasopharyngeal carcinoma patients

更新时间：2025-12-31

- Dysphagia after radiotherapy: esophageal barium fluoroscopy examination of swallowing in nasopharyngeal carcinoma patients
- China Oncology Vol. 25, Issue 5, Pages: 371-376(2015)
- 作者机构：
  
  1. 福建医科大学教学医院，福建省肿瘤医院放疗科,福建,福州,350014
  2. 福建医科大学省立临床医学院,福建,福州,350014
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2015.05.009
  CLC：
- Published Online：11 August 2015，
  
  Published：11 August 2015
- 稿件说明：
移动端阅览
林冯杰,徐鹭英,陈惠琴,等. 食道钡剂造影在评价鼻咽癌放疗后吞咽功能障碍中的运用[J]. 中国癌症杂志, 2015, 25(5): 371-376.

林冯杰, 徐鹭英, 陈惠琴. Dysphagia after radiotherapy: esophageal barium fluoroscopy examination of swallowing in nasopharyngeal carcinoma patients[J]. China Oncology, 2015, 25(5): 371-376.
林冯杰,徐鹭英,陈惠琴,等. 食道钡剂造影在评价鼻咽癌放疗后吞咽功能障碍中的运用[J]. 中国癌症杂志, 2015, 25(5): 371-376. DOI： 10.3969/j.issn.1007-3969.2015.05.009.

林冯杰, 徐鹭英, 陈惠琴. Dysphagia after radiotherapy: esophageal barium fluoroscopy examination of swallowing in nasopharyngeal carcinoma patients[J]. China Oncology, 2015, 25(5): 371-376. DOI： 10.3969/j.issn.1007-3969.2015.05.009.

摘要

背景与目的：鼻咽癌放疗后吞咽功能障碍评价方法多为主观的问卷调查，缺乏有效的客观检测方法，本研究旨在探索鼻咽癌放疗后吞咽功能障碍的评价方法，了解鼻咽癌放疗后吞咽功能障碍的发病情况及其严重程度。方法：连续选取2013年10月—2013年12月门诊复查的128例鼻咽癌放疗后患者，其中调强放疗(intensity modulated radiation therapy，IMRT)组患者89例，常规放疗(conventional radiotherapy，CRT)组患者39例。采用食道钡剂造影方法，评价吞咽功能障碍情况。每位患者吞食3种不同浓度的钡剂，并在X线透视下动态观察不同浓度钡剂在通过口腔、咽部和食道时是否存在以下问题：①在口腔受阻无法下咽；②分流至声门或气管；③潴留在梨状窝和舌会厌隙；④舌骨、会厌活动受限；⑤通过咽部不畅，时间延长；⑥通过食道入口处速度减慢。结果：在128例患者中，食道钡剂造影检测出吞咽功能障碍总发生率为60.2%，调强组和常规组分别为52.8%和76.9%(P=0.018)；放疗后1年内、1~2年和2年后发病率分别为63.1%、33.3%和69.0%(P=0.019)。结论：鼻咽癌放疗后吞咽功能障碍较多见，采用IMRT的患者其发生率较低。食道钡剂造影可以客观的评价鼻咽癌放疗后吞咽功能障碍的发病情况及其严重程度。

Abstract

Background and purpose: Currently

subjective questionaire is the most frequently used methods to evaluate swallowing dysfunctions after radiotherapy in nasopharyngeal carcinoma patients

while lacking of effective objective examinations. This study aimed to explore effective methods to evaluate swallowing dysfunctions after radiotherapy in nasopharyngeal carcinoma patients

and gain knowledge of the incidence and severity of swallowing dysfunctions. Methods: From Oct. 2013 to Dec. 2013

128 consecutive outpatients with previously treated nasopharyngeal carcinoma received esophageal barium fluoroscopy examination at there regularly follow-ups to evaluate swallowing function. Among these patients

89 were primary treated with intensity modulated radiation therapy (IMRT) and 39 with conventional radiotherapy (CRT). In this study

each patient received esophageal barium fluoroscopy examination for 3 times with thin

thick and pasty barium and were dynamically observed using X-ray fluoroscopy from front and lateral direction. Swallowing dysfunctions were defined as follows: ①The bolus could not be swallowed and blocked in the mouth; ②The dilute barium diverted to the glottis or trachea; ③Residual barium delayed in the pyriform sinus and vallecula; ④The movement of the hyoid bone or epiglottis were restricted; ⑤Bolus prolong through the pharynx; ⑥Barium slowed down when went though the esophageal entrance. Results: Of the 128 patients

incidence of dysphagia was 60.2% for the entire cohort

52.8% for IMRT group and 76.9% for CRT group. Incidence of dysphagia for IMRT group was significantly lower than CRT group (P=0.018). Dysphagia incidence within 1 year

1 to 2 years and more than 2 years after RT were 63.1%

33.3% and 69.0%

respectively (P=0.019). Conclusion: There was a high incidence of swallowing dysfunction for the nasopharyngeal carcinoma patients treated with radiotherapy and dysphagia incidence decreased when treated with IMRT. Esophageal barium fluoroscopy examination is objective method to evaluate the incidence and severity of the swallowing dysfunction.

关键词

Keywords

references

Views

2289

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Treatment strategies and prognostic analysis of 87 patients with salivary duct carcinoma: a retrospective cohort study

The diagnostic value of zero echo time magnetic resonance imaging for skull base bone invasion in nasopharyngeal carcinoma

A comparative analysis of the long-term efficacy between partial hepatectomy and transcatheter arterial chemoembolization in patients with liver metastasis from nasopharyngeal carcinoma

Study on the mechanism of DDX6 promoting proliferation and migration of nasopharyngeal carcinoma cells by regulating stability of CKMT1A mRNA

Advancements in the research of immunomodulatory effects of radiation therapy: from basic to clinical

Related Author

Ximei ZHANG

Yixuan ZHOU

Yan ZHAO

Xuan ZHOU

Xudong WANG

Yingbin YAN

Peiguo WANG

Jiahao LIN

Related Institution

Department of Maxillofacial Surgery, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Malignant Tumors

Tianjin Key Laboratory of Oral and Maxillofacial Functional Reconstruction

Department of Oral and Maxillofacial-Head and Neck Surgery, Tianjin Stomatological Hospital Affiliated to Nankai University School of Medicine

Stomatological Clinical College of Tianjin Medical University

Tianjin Clinical Research Center for Malignant Tumors

AI问答

⁰