The value of pancreatic CT perfusion on biological behavior assessment in pancreatic cancer

孟凡斌; 郭克建; 葛春林

doi:10.3969/j.issn.1007-3969.2015.05.012

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The value of pancreatic CT perfusion on biological behavior assessment in pancreatic cancer

更新时间：2025-12-31

- The value of pancreatic CT perfusion on biological behavior assessment in pancreatic cancer
- China Oncology Vol. 25, Issue 5, Pages: 387-391(2015)
- 作者机构：
  
  中国医科大学附属第一医院普通外科教研室胰腺外科,辽宁,沈阳,110001
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2015.05.012
  CLC：
- Published Online：11 August 2015，
  
  Published：11 August 2015
- 稿件说明：
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孟凡斌,郭克建,葛春林,等. 胰腺CT灌注扫描在胰腺癌生物学行为评估中的价值[J]. 中国癌症杂志, 2015, 25(5): 387-391.

孟凡斌, 郭克建, 葛春林. The value of pancreatic CT perfusion on biological behavior assessment in pancreatic cancer[J]. China Oncology, 2015, 25(5): 387-391.
孟凡斌,郭克建,葛春林,等. 胰腺CT灌注扫描在胰腺癌生物学行为评估中的价值[J]. 中国癌症杂志, 2015, 25(5): 387-391. DOI： 10.3969/j.issn.1007-3969.2015.05.012.

孟凡斌, 郭克建, 葛春林. The value of pancreatic CT perfusion on biological behavior assessment in pancreatic cancer[J]. China Oncology, 2015, 25(5): 387-391. DOI： 10.3969/j.issn.1007-3969.2015.05.012.

摘要

背景与目的：胰腺癌预后极差。本研究旨在探讨胰腺CT灌注扫描在胰腺癌肿瘤生物学行为评估中的价值。方法：收集用灌注CT进行诊断的胰腺癌78例，对比正常胰腺及胰腺癌组织血流量(blood flow，BF)、血容量(blood volume，BV)、渗透性(permeability，per)，峰值(peak value，PE)及达峰时间(time to peak，TTP)等参数的差别，并结合临床、病理资料对比分析癌组织各灌注参数水平与反映肿瘤生物学行为指标间的关系。结果：78例胰腺癌组织的BF值、BV值、per值及PE值均较周围正常胰腺组织显著减低。血清CA199升高及肿瘤组织CA199表达阳性者BF值明显高于正常者；组织Ki-67阳性者PE值显著高于阴性者；组织CEA阳性者TTP值显著低于阴性者；高分化胰腺癌组织Per值显著高于中、低分化者。结论：胰腺灌注CT扫描在判断胰腺癌肿瘤生物学行为方面有应用前景。

Abstract

Background and purpose: The prognosis of pancreatic cancer is poor. This study aimed to evaluate the value of pancreatic CT perfusion on biological behavior assessment in pancreatic cancer. Methods: This study collected 78 cases of pancreatic cancer which diagnosed by the method of pancreatic CT perfusion

and detected the differences of the values of blood flow (BF)

blood volume (BV)

permeability (per)

peak value (PE) and time to peak (TTP) between normal pancreatic tissues and tumor tissues. Combined with clinical and pathological data. Besides

this study evaluated the relationship between perfusion parameters of tumor tissues and tumor size

lymph node metastasis

distant metastasis

preoperative serum CA199 level

Ki-67

p53

CEA

CA199

CD34 expression of tumor tissues. Results: The values of BF

per and PE in pancreatic tumor tissue were significantly lower than those in normal pancreatic tissue. The BF values of cases with high levels of serum CA199 and with CA199 positively expressed tissues were significantly higher than those with negative expression. The PE values of cases with positive tissue expression of Ki-67 were significantly higher than those with negative expression. The TTP values of cases with positive tissue expression of CEA were significantly lower than those with negative expression. The per values of well differentiated cases was significantly higher than those of moderately/poorly differentiated cases. Conclusion: CT perfusion may have its value on assessment of tumor biological behavior in pancreatic cancer.

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