Research progress of treatment and therapeutic target for Luminal B breast cancer

孙运坡; 应学翔; 何萍青

doi:10.3969/j.issn.1007-3969.2015.07.011

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Research progress of treatment and therapeutic target for Luminal B breast cancer

更新时间：2025-12-31

- Research progress of treatment and therapeutic target for Luminal B breast cancer
- China Oncology Vol. 25, Issue 7, Pages: 555-560(2015)
- 作者机构：
  
  上海交通大学附属第六人民医院普外科,上海,200233
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2015.07.011
  CLC：
- Published Online：09 December 2015，
  
  Published：09 December 2015
- 稿件说明：
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孙运坡,应学翔,何萍青. Luminal B型乳腺癌的治疗及其靶点的研究进展[J]. 中国癌症杂志, 2015, 25(7): 555-560.

孙运坡, 应学翔, 何萍青. Research progress of treatment and therapeutic target for Luminal B breast cancer[J]. China Oncology, 2015, 25(7): 555-560.
孙运坡,应学翔,何萍青. Luminal B型乳腺癌的治疗及其靶点的研究进展[J]. 中国癌症杂志, 2015, 25(7): 555-560. DOI： 10.3969/j.issn.1007-3969.2015.07.011.

孙运坡, 应学翔, 何萍青. Research progress of treatment and therapeutic target for Luminal B breast cancer[J]. China Oncology, 2015, 25(7): 555-560. DOI： 10.3969/j.issn.1007-3969.2015.07.011.

摘要

根据基因表达谱的不同，乳腺癌被分成4种不同的亚型：基底样型、人类表皮生长因子受体2(HER-2)过表达型、Luminal A型和Luminal B型。尽管Luminal型乳腺癌存在相似之处，但研究发现Luminal A型和Luminal B型乳腺癌是两种不同的实体。Luminal B型乳腺癌激素受体低表达，该类型乳腺癌预后相对较差，对化疗及内分泌治疗的反应不同。该文回顾了Luminal B型乳腺癌对化疗及内分泌治疗不同反应的临床依据，以及目前正在研究的新的治疗靶点。

Abstract

Breast cancer can be classified into 4 intrinsic subtypes by gene expression profiling: basal-like

HER-2-positive

Luminal A and Luminal B. Although Luminal cancers share similarities

the studies showed that Luminal A and B breast cancers should be perceived as distinct entities. Luminal B breast cancer has lower expression of hormone receptors

and it also exhibits worse prognosis and has a distinct profile of response to chemotherapy and endocrine therapy. This review presented the available clinical evidence for chemotherapy and endocrine therapy patterns of response

and potential targets for treatment.

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Related Institution

Department of Oncology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University

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上海交通大学附属第六人民医院肿瘤内科

Phase Ⅰ Clinical Trial Center, Fudan University Shanghai Cancer Center; Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University

Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

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