Study of impact of operation time interval after neoadjuvant chemoradiotherapy for locally progressed rectal patients’ outcome

张　斌; 汪　昱

doi:10.3969/j.issn.1007-3969.2015.08.013

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Study of impact of operation time interval after neoadjuvant chemoradiotherapy for locally progressed rectal patients’ outcome

更新时间：2025-12-31

- Study of impact of operation time interval after neoadjuvant chemoradiotherapy for locally progressed rectal patients’ outcome
- China Oncology Vol. 25, Issue 8, Pages: 635-640(2015)
- 作者机构：
  
  上海交通大学附属第六人民医院普外科,上海,200233
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2015.08.013
  CLC：
- Published Online：14 December 2015，
  
  Published：14 December 2015
- 稿件说明：
移动端阅览
张　斌,汪　昱. 新辅助放化疗后手术时机选择对进展期直肠癌患者预后影响的研究进展[J]. 中国癌症杂志, 2015, 25(8): 635-640.

张　斌, 汪　昱. Study of impact of operation time interval after neoadjuvant chemoradiotherapy for locally progressed rectal patients’ outcome[J]. China Oncology, 2015, 25(8): 635-640.
张　斌,汪　昱. 新辅助放化疗后手术时机选择对进展期直肠癌患者预后影响的研究进展[J]. 中国癌症杂志, 2015, 25(8): 635-640. DOI： 10.3969/j.issn.1007-3969.2015.08.013.

张　斌, 汪　昱. Study of impact of operation time interval after neoadjuvant chemoradiotherapy for locally progressed rectal patients’ outcome[J]. China Oncology, 2015, 25(8): 635-640. DOI： 10.3969/j.issn.1007-3969.2015.08.013.

摘要

进展期直肠癌行新辅助放化疗(neoadjuvant chemoradiotherapy，nCRT)后的延期手术可以增加根治切除机会，降低局部复发，同时改善患者总体生存率。常规的术前放化疗与手术之间的时间间隔为4~6周，延长手术时间间隔可以增加肿瘤退缩的程度，但是超过6~8周也可能会增加手术难度、手术并发症发生率及肿瘤复发或转移的风险。回顾分析相关文献，从肿瘤缓解率、预后、患病率和死亡率等方面对nCRT后延期手术时机选择对预后影响的研究进展进行综述。

Abstract

Neoadjuvant chemoradiotherapy (nCRT) is used to downstage locally advanced rectal cancer before surgery

in order to increase the chance of radical resection

reduce local recurrence

and improve overall survival. Accumulating data suggest that tumor response to nCRT is time dependent. A delay between nCRT and surgery may increase the proportion of patients that achieve a favorable response

and 4-6 weeks are considered to be a universal interval. However

delayed surgery beyond 6-8 weeks may increase the technical difficulty

and the risks of surgical complications and recurrence or metastasis. This article briefly reviews the relevant literature to evaluate the efficiency and safety of delayed surgery.

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