Dosimetric study of simplified intensity-modulated radiation therapy for nasopharyngeal carcinoma

李凯旋; 王佳舟; 姜　睿

doi:10.3969/j.issn.1007-3969.2015.12.010

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Dosimetric study of simplified intensity-modulated radiation therapy for nasopharyngeal carcinoma

更新时间：2025-12-31

- Dosimetric study of simplified intensity-modulated radiation therapy for nasopharyngeal carcinoma
- China Oncology Vol. 25, Issue 12, Pages: 978-982(2015)
- 作者机构：
  
  复旦大学附属肿瘤医院放射治疗科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.1007-3969.2015.12.010
  CLC：
- Published Online：03 February 2016，
  
  Published：03 February 2015
- 稿件说明：
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李凯旋,王佳舟,姜　睿,等. 简化调强技术在鼻咽癌外照射中应用的剂量学研究[J]. 中国癌症杂志, 2015, 25(12): 978-982.

李凯旋, 王佳舟, 姜　睿. Dosimetric study of simplified intensity-modulated radiation therapy for nasopharyngeal carcinoma[J]. China Oncology, 2015, 25(12): 978-982.
李凯旋,王佳舟,姜　睿,等. 简化调强技术在鼻咽癌外照射中应用的剂量学研究[J]. 中国癌症杂志, 2015, 25(12): 978-982. DOI： 10.3969/j.issn.1007-3969.2015.12.010.

李凯旋, 王佳舟, 姜　睿. Dosimetric study of simplified intensity-modulated radiation therapy for nasopharyngeal carcinoma[J]. China Oncology, 2015, 25(12): 978-982. DOI： 10.3969/j.issn.1007-3969.2015.12.010.

摘要

背景与目的：放射治疗是治疗鼻咽癌的首选方法。该文旨在研究简化调强放射治疗(simplified intensity-modulated radiation therapy，sIMRT )与调强放疗(intensity-modulated radiation therapy，IMRT)技术在鼻咽癌(nasopharyngeal carcinoma，NPC)放射治疗中的剂量学差异。方法：对10例NPC患者以相同处方剂量和目标条件分别设计9野IMRT和sIMRT计划，比较两种计划靶区剂量分布和剂量适形指数(conformity index，CI)与均匀性指数(homogeneity index，HI)，不同危及器官(organ at risk，OAR)剂量参数、机器总跳数(MU)和总子野数。结果：IMRT和sIMRT的CI、HI分别为0.647、0.057和0.633、0.071(t=2.14，P=0.062；t=-6.21，P=0.000)，sIMRT计划的靶区均匀性略差于IMRT，但两种治疗计划均能满足临床剂量学的要求。两种计划中各OAR剂量参数差异无统计学意义(t=-0.51~2.22，P=0.053~0.621) 。sIMRT计划的机器总跳数和总子野数均少于IMRT计划。结论：鼻咽癌sIMRT计划的靶区剂量覆盖与IMRT计划相当，均匀性略差于IMRT；危及器官受照剂量相当，但sIMRT技术可显著减少机器总跳数和总子野数，对患者数量大的治疗中心提高治疗效率具有较高的优势。

Abstract

Background and purpose: Radiotherapy has been the preferred method for the treatment of nasopharyngeal carcinoma (NPC). The aim of this paper was to compare the dosimetric differences in target volume and organ at risk between simplified intensity-modulated radiation therapy (sIMRT) and intensity-modulated radiation therapy (IMRT) in nasopharyngeal carcinoma. Methods: Treatment plans for ten NPC cases were designed with the same dose prescription and objective by means of IMRT and sIMRT respectively. Compare:(1) Plan dosimetric distribution

conformity index (CI) and homogeneity index (HI) of the targets

the dosimetric parameters of organ at risk (OAR); (2)The total monitor units (MU) and the total segments. Results: The CI and HI of the planning gross tumor volume(PGTV) were 0.647 and 0.057 (IMRT)

0.633 and 0.071 (sIMRT)

respectively (t=2.14

P=0.062; t=-6.21

P=0.000). Compared to IMRT

sIMRT had less inferior target homogeneity. However both treatment plans could achieve the clinical dosimetric demands. There was no significant difference between IMRT and sIMRT in protecting OAR (t=-0.51-2.22

P=0.053-0.621). The sIMRT plan was better than IMRT plan in total MU and total segments. Conclusion: sIMRT is slightly inferior to IMRT in terms of target homogeneity

with similar target conformity and OAR dosimetric parameters. The sIMRT plan can reduce total monitor units and total segments. Thus it provides a clinical solution with high efficiency for radiotherapy center with a large number of patients.

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