纳米炭在早期低位直肠癌根治手术中的应用价值

杨　洋; 李良庆; 陈思曾

doi:10.19401/j.cnki.1007-3639.2016.11.007

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纳米炭在早期低位直肠癌根治手术中的应用价值

更新时间：2025-12-31

- 纳米炭在早期低位直肠癌根治手术中的应用价值
- The application of domestic nanometer activated carbon in the radical operation for early stage lowlying rectal cancer
- 中国癌症杂志 2016年26卷第11期页码：922-925
- 作者机构：
  
  福建医科大学附属第一医院胃肠外科一区,福建,福州,350005
- 作者简介：
- 基金信息：
  
  国家临床重点专科建设项目;国家自然科学基金(81272465)。
- DOI：10.19401/j.cnki.1007-3639.2016.11.007
  中图分类号：
- 网络出版：2017-01-22，
  
  纸质出版：2016-01-22
- 稿件说明：
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杨　洋,李良庆,陈思曾,等. 纳米炭在早期低位直肠癌根治手术中的应用价值[J]. 中国癌症杂志, 2016, 26(11): 922-925.

杨　洋, 李良庆, 陈思曾. The application of domestic nanometer activated carbon in the radical operation for early stage lowlying rectal cancer[J]. China Oncology, 2016, 26(11): 922-925.
杨　洋,李良庆,陈思曾,等. 纳米炭在早期低位直肠癌根治手术中的应用价值[J]. 中国癌症杂志, 2016, 26(11): 922-925. DOI： 10.19401/j.cnki.1007-3639.2016.11.007.

杨　洋, 李良庆, 陈思曾. The application of domestic nanometer activated carbon in the radical operation for early stage lowlying rectal cancer[J]. China Oncology, 2016, 26(11): 922-925. DOI： 10.19401/j.cnki.1007-3639.2016.11.007.

摘要

背景与目的：纳米炭混悬注射液是新近出现的一种淋巴结示踪剂，该研究旨在评价其在早期低位直肠癌根治手术中淋巴结清扫的应用价值。方法：分析2013年1月—2015年12月收治的早期低位直肠癌患者66例，随机分为研究组(术前肠镜下注射纳米炭)和对照组，观察两组平均淋巴结检出数和微小淋巴结比例等指标。研究组还获取前哨淋巴结(sentinel lymph node，SLN)行病理学检查。结果：两组平均淋巴结检出数和微小淋巴结比例对比，差异均有统计学意义(P0.05)，前哨淋巴结检出准确率达90.9%，假阴性率为3.8%，无明显并发症。结论：术前注射纳米炭混悬液是有助于早期低位直肠癌淋巴结清扫，同时SLN活检是可行的。

Abstract

Background and purpose: This study aimed to estimate the spike-effect of domestic nanometer activated carbon on the radical operation for early stage low-lying rectal cancer. Methods: From Jan. 2013 to Dec. 2015

66 patients with early stage low-lying rectal cancer were randomly divided into two groups: study group and control group. The patients of study group were treated with injection of carbon nanoparticles suspension in tumor vicinity before the operation. This study compared the total number of lymph node

the scale percentage of micro lymph node between two groups. SLNs of study group were obtained for pathological examination. Results: The differences in the total number of lymph node and the scale percentage of micro lymph node between two groups were statistically significant (P0.05). The diagnostic sensitivity and false-negative rate were 90.9% and 3.8%

respectively. Conclusion: Local injection of nanometer activated carbon around the tumor is important to the metastasis lymph node resection

especially to SLN biopsy in the radical operation for rectal cancer.

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