Background and purpose: Ovarian cancer is one of the most lethal gynecologic cancers worldwide. This study aimed to analyze the incidence and mortality of ovarian cancer among local residents in the Former Luwan District in Shanghai from Jan. 2002 to Dec. 2011. Methods: Data of ovarian cancer in permanent residents of Shanghai Former Luwan District were extracted from the Shanghai cancer registration and management system. We calculated the incidence and mortality of ovarian cancer. The standardized rates were calculated based on the demographic composition developed in the Fifth Nationwide Census in the year 2000

and the Seig’s world standard. The temporal trend in the incidence and mortality of ovarian cancer was assessed using average annual percentage change (APC). Results: A total of 236 new cases were diagnosed from Jan. 2002 to Dec. 2011

accounting for 3.76% of the total female patients with malignant diseases. Ovarian cancer incidence stayed relatively stable between 2002 and 2011. A total of 111 cases died of ovarian cancer during this period

accounting for 3.05% of the total female patients died from malignant diseases. The mortality rates of ovarian cancer during these 10 years were also stable. Conclusion: The incidence and mortality rates of ovarian cancer were relatively stable during the period from 2002 to 2011. Older women are at the highest risk of ovarian cancer occurrence. Ovarian cancer is experiencing a trend of earlier occurrence and death in the younger age group. Morbidity and mortality can occur at all ages. Effective prevention and treatment strategies are urgently needed to improve women’s health.