As a safe and effective substitute and supplement of neoadjuvant chemotherapy (NCT)

neoadjuvant hormonal therapy (NHT) has been increasingly used in patients with locally advanced breast cancer whose hormone receptors are positive. However

there are many controversies of NHT in the standard treatment

indications and assessment of the treatment effects. To review the current situation and research progress of NHT

this article discusses the following aspects: comparison of NCT and NHT

comparison of different NHT treatments

duration of NHT

combination of NHT and other neoadjuvant treatments

predictors of response and prognosis

and adjuvant radiation indications after NHT.