结直肠癌及腺瘤患者CD4+、CD8+和CD28+T淋巴细胞的亚群变化及临床意义

邱思芳

doi:10.19401/j.cnki.1007-3639.2018.08.003

您当前的位置：

首页 >

文章列表页 >

结直肠癌及腺瘤患者CD4⁺、CD8⁺和CD28⁺T淋巴细胞的亚群变化及临床意义

论著 | 更新时间：2026-01-27

- 结直肠癌及腺瘤患者CD4⁺、CD8⁺和CD28⁺T淋巴细胞的亚群变化及临床意义
- Subsets and clinical significance of CD4⁺, CD8⁺and CD28⁺T lymphocytes in the patients with colorectal carcinoma and adenoma
- 中国癌症杂志 2018年28卷第8期页码：577-583
- 作者机构：
  
  遵义医学院附属医院消化内科,贵州,遵义,563000
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助项目（81560467）;贵州省高层次人才科研条件特助基金资助项目（TZIF2011-32）;贵州省科学技术基金资助项目（LKZ2013-18）;遵义医学院博士科研启动基金（F-572）;贵州省卫生计生委科学技术基金项目（gzwjkj2017-1-001）。
- DOI：10.19401/j.cnki.1007-3639.2018.08.003
  中图分类号： R735.34
- 网络出版：2018-09-14，
  
  纸质出版：2018-09-14
- 稿件说明：
移动端阅览
张泉,邱思芳,赵逵,等. 结直肠癌及腺瘤患者CD4

邱思芳. Subsets and clinical significance of CD4⁺, CD8⁺and CD28⁺T lymphocytes in the patients with colorectal carcinoma and adenoma[J]. China Oncology, 2018, 28(8): 577-583.
张泉,邱思芳,赵逵,等. 结直肠癌及腺瘤患者CD4 DOI： 10.19401/j.cnki.1007-3639.2018.08.003.

邱思芳. Subsets and clinical significance of CD4⁺, CD8⁺and CD28⁺T lymphocytes in the patients with colorectal carcinoma and adenoma[J]. China Oncology, 2018, 28(8): 577-583. DOI： 10.19401/j.cnki.1007-3639.2018.08.003.

摘要

背景与目的：结直肠癌（colorectal cancer，CRC）严重影响患者生存。探讨肿瘤微环境（tumor microenvironment，TME）T细胞亚群在CRC和腺瘤中的表达及意义。方法：用免疫组织化学法和流式细胞术对51例健康人（对照组）、46例结直肠腺瘤（腺瘤组）、100例CRC（癌症组）和15例CRC术后（癌术后组）患者进行T细胞亚群检测。结果：① 对照组、腺瘤组及癌症组3组中CD4

T细胞的阳性率分别是90.00%、43.75%及32.65%，CD8

T淋巴细胞的阳性率分别是30.00%、56.25%及75.51%，CD28

T淋巴细胞的阳性率分别是42.86%、30.00%及20.00%。② 对照组、腺瘤组及癌症组3组中CD4

、CD4

/CD8

、CD28

、CD8

CD28

和CD8

－

CD28

逐渐降低，CD8

、CD8

CD28

－

逐渐增加（P＜0.05）；癌术前术后T细胞亚群差异有统计学意义（P＜0.05）。结论：① CRC微环境T细胞亚群中CD4

、CD4

/CD8

、CD28

、CD8

CD28

和CD8

－

CD28

呈递减趋势，CD8

、CD8

CD28

－

呈递增趋势，且在癌前病变腺瘤中已逐步出现上述趋势变化。② CRC患者行肿瘤切除术后，其T细胞亚群有所恢复，故在一定程度上，CRC中T细胞亚群的变化可以早期预测结直肠疾病的发展。

Abstract

Background and purp

ose: Colorectal cancer (CRC) is a disease that seriously affects the quality of life. This study aimed to investigate the subsets and significance of tumor cell microenvironment T cell in CRC and adenoma. Methods: Immunohistochemistry and flow cytometry were used to test T lymphocyte subsets in 51 healthy subjects (control group)

46 patients with colorectal adenomas (adenoma group)

100 CRC patients (cancer group)

and 15 postoperative patients with CRC (postoperative group). Results: The positive rates of CD4

T cells in the control group

adenoma group and cancer group were 90.00%

43.75% and 32.65%

respectively. The positive rates of CD8

T lymphocytes were 30.00%

56.25% and 75.51%

respectively. The positive rates of CD28

T lymphocytes were 42.86%

30.00% and 20.00%

respectively. The levels of CD4

CD4

/CD8

CD28

CD8

CD28

and CD8

－

CD28

in the control group

adenoma group and cancer group gradually decreased

while the CD8

and CD8

CD28

－

levels gradually increased (P0.05). The difference in T cell subsets between preoperative and postoperative patients was statistically significant (P0.05). Conclusion: CD4

CD4

/CD8

CD28

CD8

CD28

and CD8

－

CD28

in the subgroup of colorectal tumor microenvironment showed a declining trend

while CD8

and CD8

CD28

－

showed an increasing trend. Moreover

these trends gradually appeared in precancerous adenomas. After CRC patients underwent tumor resection

their T cell subsets recovered. Therefore

to some extent

the changes of T cell subsets in CRC can predict the development of colorectal disease early.

关键词

Keywords

references

浏览量

6417

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

靶向治疗及免疫治疗联合化疗为产AFP阳性结肠癌患者带来显著获益1例病例报告并文献复习

MYC通过靶向CD47促进前列腺癌增殖和转移的机制研究

Tepoxalin通过ABCB1影响结直肠癌细胞生长及耐药的分子机制研究

没食子酸增强CAR-T细胞抗实体瘤作用的研究

循环肿瘤细胞在胆管癌侵袭转移中的作用机制研究进展及展望