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上海交通大学附属胸科医院放疗科,上海,200030
网络出版:2019-06-03,
纸质出版:2019-06-03
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尹翼鹏晨,张 琴,傅小龙. 纳米材料在肿瘤诊疗中的应用研究进展[J]. 中国癌症杂志, 2019, 29(5): 328-337.
尹翼鹏晨, 张 琴, 傅小龙. Research progress on applications of nanomaterials in cancer theranostics[J]. China Oncology, 2019, 29(5): 328-337.
尹翼鹏晨,张 琴,傅小龙. 纳米材料在肿瘤诊疗中的应用研究进展[J]. 中国癌症杂志, 2019, 29(5): 328-337. DOI: 10.19401/j.cnki.1007-3639.2019.05.002.
尹翼鹏晨, 张 琴, 傅小龙. Research progress on applications of nanomaterials in cancer theranostics[J]. China Oncology, 2019, 29(5): 328-337. DOI: 10.19401/j.cnki.1007-3639.2019.05.002.
恶性肿瘤是目前影响人类健康的头号元凶。尽管肿瘤诊断与治疗的手段不断发展,但是由于肿瘤的异质性、隐匿性等原因,现有的肿瘤诊疗手段难以有效地克服肿瘤的复发、转移。近年来,随着纳米技术的不断发展,纳米材料因其良好的理化性质,如具有肿瘤靶向性、较好的生物相容性、易于功能化等,在肿瘤诊疗方面受到广泛关注,已有多项产品进入临床试验阶段或投入应用。对纳米材料在肿瘤诊断、化疗、放疗、光疗及免疫治疗等相关方面的应用研究进行了综述,并对其发展趋势予以了展望。
Cancer is one of the leading causes of human death around the world. Despite of great advances in cancer diagnosis and treatment
also known as cancer theranostics
treatment responses
however
are often impeded by heterogeneity and stealthiness of cancer. Recently
with the fast development of nanotechnology
nanomaterials exhibit great potential in cancer theranostics for their excellent physiochemical properties including tumor targeting
good biocompatibility and easy functionalization. Moreover
a wide variety of nano-drugs have been tested in clinical trials
and some of them have been approved for human use. In this review
we aimed to provide insights into the applications of nanomaterials for innovative cancer diagnosis as well as enhanced chemotherapy
radiation therapy
phototherapy and immunotherapy of cancer. Additionally
we highlighted some examples and prospect for the further development of cancer nanotheranostics.
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