E R阳性乳腺癌中FGFR1蛋白的表达与ER及预后的关系

王宇航; 宋全福; 吴俊强; 南丁阿比雅斯; 阿勒哈; 庞　达; 姜永冬

doi:10.19401/j.cnki.1007-3639.2019.05.004

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E R阳性乳腺癌中FGFR1蛋白的表达与ER及预后的关系

论著 | 更新时间：2026-01-27

- E R阳性乳腺癌中FGFR1蛋白的表达与ER及预后的关系
- FGFR1 protein level is associated with ER expression and prognosis in ER-positive breast cancer
- 中国癌症杂志 2019年29卷第5期页码：345-351
- 作者机构：
  
  1. 哈尔滨医科大学附属肿瘤医院乳腺外科,黑龙江,哈尔滨,150081
  2. 哈尔滨医科大学附属肿瘤医院病理科,黑龙江,哈尔滨,150081
  3. 阿勒泰地区人民医院肿瘤科，新疆维吾尔族自治区,阿勒泰,836000
- 作者简介：
- 基金信息：
  
  国家自然科学基金（81202075）。
- DOI：10.19401/j.cnki.1007-3639.2019.05.004
  中图分类号： R737.9
- 网络出版：2019-06-03，
  
  纸质出版：2019-06-03
- 稿件说明：
移动端阅览
王宇航，宋全福，吴俊强，南丁阿比雅斯，阿勒哈，庞　达，姜永冬. E R阳性乳腺癌中FGFR1蛋白的表达与ER及预后的关系[J]. 中国癌症杂志, 2019, 29(5): 345-351.

王宇航, 宋全福, 吴俊强, et al. FGFR1 protein level is associated with ER expression and prognosis in ER-positive breast cancer[J]. China Oncology, 2019, 29(5): 345-351.
王宇航，宋全福，吴俊强，南丁阿比雅斯，阿勒哈，庞　达，姜永冬. E R阳性乳腺癌中FGFR1蛋白的表达与ER及预后的关系[J]. 中国癌症杂志, 2019, 29(5): 345-351. DOI： 10.19401/j.cnki.1007-3639.2019.05.004.

王宇航, 宋全福, 吴俊强, et al. FGFR1 protein level is associated with ER expression and prognosis in ER-positive breast cancer[J]. China Oncology, 2019, 29(5): 345-351. DOI： 10.19401/j.cnki.1007-3639.2019.05.004.

摘要

背景与目的：乳腺癌是严重危害女性健康的常见恶性肿瘤之一，内分泌治疗是乳腺癌综合治疗中的重要措施之一。约30%激素敏感型乳腺癌患者并不能从内分泌治疗中获益。成纤维细胞生长因子受体1（fibroblast growth factor receptors 1，FGFR1）的表达与雌激素受体（estrogen receptor，ER）阳性乳腺癌患者内分泌治疗耐药可能有关。该研究旨在探讨ER阳性乳腺癌中FGFR1蛋白的表达水平对乳腺癌临床病理学特征及预后的影响。方法：选取哈尔滨医科大学附属肿瘤医院2008年9月-2011年12月收治的184例ER阳性乳腺癌患者，通过免疫组织化学方法检测FGFR1蛋白的表达；采用χ

检验评估FGFR1蛋白水平与乳腺癌临床病理学特征的关系；采用Spearman相关分析评估变量间是否存在相关性；运用COX回归及Kaplan-Meier法分析FGFR1表达水平对乳腺癌预后的影响。结果：在ER阳性乳腺癌中，FGFR1高表达的患者更易发生区域淋巴结转移（P=0.012，r=0.186），且FGFR1的表达水平与ER的表达水平之间存在显著的负相关关系（P=0.011，r=-0.221）。COX单因素分析显示，TNM分期、区域淋巴结转移情况、Ki-67阳性率及FGFR1表达情况与ER阳性乳腺癌预后有关；进一步进行多因素分析发现，淋巴结转移情况（OR=1.744，95%CI：1.002~3.034，P=0.049）和Ki-67阳性率（OR=1.882，95%CI：1.015~3.491，P=0.045）是ER阳性乳腺癌的独立风险因素。Kaplan-Meier生存分析提示，FGFR1高表达患者预后不良（P=0.036）。结论：在ER阳性乳腺癌中，FGFR1蛋白水平与患者ER的表达水平呈显著负相关，且FGFR1高表达提示患者预后不良。

Abstract

Background and purpose: Breast cancer is one of the most common malignancies in women. Endocrine therapy is one of the most important therapeutics in breast cancer systemic therapy. However

about 30% of hormone-sensitive breast cancer patients do not benefit from endocrine therapy. The expression of fibroblast growth factor receptor 1 (FGFR1) may be involved in endocrine therapy resistance in estrogen receptor (ER)-positive breast cancer patients. FGFR1 is widely recognized for playing key roles in mammary carcinogenesis and further affecting the prognosis and therapeutic response of breast cancer. The aim of this study was to investigate the effect of FGFR1 protein expression on the clinicopathological features and prognosis of ERpositive breast cancer. Methods: One hundred and eighty-four ER-positive breast cancer cases treated in Harbin Medical University Cancer Hospital from September 2008 to December 2011 were studied

and their FGFR1 protein expressions were measured by the immunohistochemistry method. Pearson’s chi-square test was utilized to analyze the association between FGFR1 expression and disease characteristics. COX regression and Kaplan-Meier analyses were performed to evaluate the effect of FGFR1 on the prognosis of ER-positive breast cancer. Results: The results showed that patients with higher FGFR1 expression were more likely to have lymph node metastasis (P=0.012

r=0.186)

and their ER levels were negatively associated with FGFR1 expression (P=0.011

r=-0.221). In univariate COX regression analyses

TNM stage

regional lymph node metastasis status

Ki-67 positive rate and FGFR1 expression were correlated with the prognosis of ER-positive breast cancer. It was found by multiple factors analysis of data that lymph node metastasis status (OR=1.744

95%CI: 1.002-3.034

P=0.049) and Ki-67 positive rate (OR=1.882

95%CI: 1.015-3.491

P=0.045) were independent prognostic factors for ER-positive breast cancer. Kaplan-Meier analysis showed that high indicate FGFR1 expression was correlated with decreased overall survival (P=0.036). Conclusion: There was a significant negative correlation between FGFR1 expression and ER level in ER-positive breast cancer

and high FGFR1 protein level was associated with a poor prognosis.

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