<sup>18</sup>F-FLT PET/CT对食管鳞癌放化疗效果预测研究

任文佳; 周　敏; 吴式琇; 陈俊强; 陈亚楠; 陈维维; 艾沓杉; 陈　贇; 蒋国梁; 赵快乐

doi:10.19401/j.cnki.1007-3639.2019.12.008

您当前的位置：

首页 >

文章列表页 >

¹⁸F-FLT PET/CT对食管鳞癌放化疗效果预测研究

更新时间：2026-01-27

- ¹⁸F-FLT PET/CT对食管鳞癌放化疗效果预测研究
- Prognostic and predictive value of¹⁸F-FLT PET/CT in patients with esophageal squamous carcinoma treated by radiochemotherapy
- 中国癌症杂志 2019年第12期页码：965-970
- 作者机构：
  
  1. 复旦大学附属肿瘤医院放疗中心，复旦大学上海医学院肿瘤学系,上海,200032
  2. 复旦大学附属肿瘤医院核医学中心，复旦大学上海医学院肿瘤学系,上海,200032
  3. 中国医学科学院肿瘤医院深圳医院放疗科,广东,深圳,518117
  4. 福建省肿瘤医院放疗科,福建,福州,350014
  5. 张家港第一人民医院，苏州大学附属张家港市医院，江苏张家港,215600
  6. 盐城市第三人民医院，南通大学第六附属医院，东南大学附属医院,江苏,盐城,224001
- 作者简介：
- 基金信息：
  
  卫生部部属医院临床学科重点项目（基于肿瘤和正常组织生物信息的个体化放疗研究）。
- DOI：10.19401/j.cnki.1007-3639.2019.12.008
  中图分类号：
- 网络出版：2020-01-08，
  
  纸质出版：2020-01-08
- 稿件说明：
移动端阅览
任文佳, 周　敏, 吴式琇, 陈俊强, 陈亚楠, 陈维维, 艾沓杉, 陈　贇, 蒋国梁, 赵快乐 .

REN Wenjia, ZHOU Min, WU Shixiu, et al. Prognostic and predictive value of¹⁸F-FLT PET/CT in patients with esophageal squamous carcinoma treated by radiochemotherapy[J]. China Oncology, 2019, (12): 965-970.
任文佳, 周　敏, 吴式琇, 陈俊强, 陈亚楠, 陈维维, 艾沓杉, 陈　贇, 蒋国梁, 赵快乐 . DOI： 10.19401/j.cnki.1007-3639.2019.12.008.

REN Wenjia, ZHOU Min, WU Shixiu, et al. Prognostic and predictive value of¹⁸F-FLT PET/CT in patients with esophageal squamous carcinoma treated by radiochemotherapy[J]. China Oncology, 2019, (12): 965-970. DOI： 10.19401/j.cnki.1007-3639.2019.12.008.

摘要

背景与目的：

F-FLT是一种细胞增殖的示踪剂。探索

F-FLT PET/CT对食管鳞癌根治性放（化）疗效果的预测价值。方法：对根治性放（化）疗的初治食管鳞癌患者，放疗前及放疗第4周行

F-FLT PET/CT扫描，记录原发灶的SUV

max-T

、转移淋巴结的SUV

max-N

等参数。随访患者总生存期（overall survival，OS）及无进展生存期（progression-free survival，PFS），分析PET/CT参数与患者预后的关系。结果：共入组39例患者，25例完成2次PET/CT扫描。

F-FLT的SUV

max-T

由基线6.63下降到1.22，淋巴结SUV

max-N

由3.69下降到1.84，但下比例与生存率无关。

F-FLT PET/CT的基线SUV

max-N

＜5.00的患者，其OS明显高于SUV

max-N

≥5.00的患者（P=0.002）。结论：对根治性放（化）疗食管鳞癌，治疗前的基线

F-FLT PET/CT的淋巴结SUV

max-N

是一个较好的预测预后参数。放疗4周时，病灶在

F-FLT PET/CT扫描中的SUV值明显下降，但不能预测预后。

Abstract

Background and purpose:

F-FLT is a proliferative radiotracer. This study aimed to evaluate the prognostic value of functional molecular image of

F-FLT PET/CT taken before and in the process of radiotherapy. Methods: Patients with newly diagnosed esophageal squamous cell carcinoma (ESCC) were enrolled in the study. All patients received radiotherapy/chemoradiotherapy. The planned dose was 61.2 Gy and 1.8 Gy per fraction respectively. The concurren

t chemotherapy was platinum

paclitaxel or fluoropyrimidine based. Patients were examined by PET with

F-fluoro-30-deoxy-30-L-fluorothymidine (FLT) at baseline and 4 weeks after treatment initiation. The overall survival (OS) and progression-free survival (PFS) were followed up. The SUV maximum (SUV

max

) of primary tumor and positive nodes were recorded. PET/CT findings were analyzed for the correlation with clinical response of patients and survival. Results: Thirty-nine patients were enrolled in the study

among whom 25 patients completed two planned PET/CT. Patients with SUV max-N ≥5.00 had worse OS (P=0.002) and PFS (P=0.01) than those with SUV

max-N

5.00. The SUV

max

of both primary tumor and lymph nodes significantly decreased in the interim scan compared to the baseline scan in FLT PET/CT

but the relationship between the change of SUV

max

and prognosis seemed to be weak. Conclusion: Baseline SUV

max

of lymph node on

F-FLT PET/CT had prognostic value in patients with esophageal cancer undergoing radiotherapy/radiochemotherapy. The decrease of SUV

max

of tumor after 4 weeks’ radiotherapy couldn’t predict prognosis properly.

关键词

Keywords

references

浏览量

1840

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

暂无数据

18F-FLT PET/CT对食管鳞癌放化疗效果预测研究

Prognostic and predictive value of18F-FLT PET/CT in patients with esophageal squamous carcinoma treated by radiochemotherapy

DOI：10.19401/j.cnki.1007-3639.2019.12.008

摘要

Abstract

关键词

Keywords

references

¹⁸F-FLT PET/CT对食管鳞癌放化疗效果预测研究

Prognostic and predictive value of¹⁸F-FLT PET/CT in patients with esophageal squamous carcinoma treated by radiochemotherapy