<sup>99m</sup>Tc-HYNIC-TOC人体内照射剂量研究

卢麟俊; 许晓平; 徐俊彦; 张建岗; 章英剑; 宋少莉; 张建平

doi:10.19401/j.cnki.1007-3639.2020.11.004

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^99mTc-HYNIC-TOC人体内照射剂量研究

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- ^99mTc-HYNIC-TOC人体内照射剂量研究
- A study on the dose of^99mTc-HYNIC-TOC in humans
- 中国癌症杂志 2020年第11期页码：872-878
- 作者机构：
  
  1. 复旦大学附属肿瘤医院核医学科，复旦大学上海医学院肿瘤学系,上海,200032
  2. 复旦大学生物医学影像研究中心,上海,200032
  3. 上海分子影像探针工程技术研究中心,上海,200032
  4. 上海市质子重离子医院核医学科,上海,201321
  5. 复旦大学核物理与离子束应用教育部重点实验室,上海,200433
- 作者简介：
- 基金信息：
  
  上海市卫健委面上项目（201740185）;上海分子影像探针工程技术研究中心项目（19DZ2282200）;国家自然科学基金（81771861，81971648）;上海市科技创新计划（18410711200，19142202100）;国家重点研发计划（2019YFC1604605）。
- DOI：10.19401/j.cnki.1007-3639.2020.11.004
  中图分类号：
- 网络出版：2020-12-07，
  
  纸质出版：2020-12-07
- 稿件说明：
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卢麟俊, 许晓平, 徐俊彦, 张建岗, 章英剑, 宋少莉, 张建平 .

LU Linjun, XU Xiaoping, XU Junyan, et al. A study on the dose of^99mTc-HYNIC-TOC in humans[J]. China Oncology, 2020, (11): 872-878.
卢麟俊, 许晓平, 徐俊彦, 张建岗, 章英剑, 宋少莉, 张建平 . DOI： 10.19401/j.cnki.1007-3639.2020.11.004.

LU Linjun, XU Xiaoping, XU Junyan, et al. A study on the dose of^99mTc-HYNIC-TOC in humans[J]. China Oncology, 2020, (11): 872-878. DOI： 10.19401/j.cnki.1007-3639.2020.11.004.

摘要

Abstract

Background and purpose: The data of radioactive imaging drug dose distribution in human body

absorbed dose of organs and effective dose of whole body are very important. The purpose of this study was to estimate the absorbed doses of different organs and the effective dose from the biodistribution of the

99m

Tc-hydrazinonicotinyl-Tyr3-octreotide (

99m

Tc-HYNIC-TOC) in humans with hybrid single photon emission computed tomography (SPECT) imaging. Methods: Whole body planar imaging was acquired at 0.5

1.0

2.0

4.0 and 8.0 h after administration of 370 MBq

99m

Tc-HYNIC-TOC to 5 patients with neuroendocrine tumors who were treated in Fudan University Shanghai Cancer Center from May to Jun. 2018

and the tomography of the whole body was achieved at 2.0 h. After iterative reconstruction

the data were imported into GE Dosimetry Toolkit. Region of interest (ROI) of different organs was delineated in SPECT/CT images

and the residence time equal to the area under the curve was calculated by time-activity curve. The absorbed doses of different organs and the whole body and the effective dose of whole body were calculated by OLINDA/EXM software according to the standard methods which were developed by Medical Internal Radiation Dose (MIRD) Committee. Res

ults: The absorbed dose coefficients of spleen

bladder and kidney (adult male: 0.042

0.019 and 0.016 mGy/MBq; adult female: 0.026

0.027 and 0.019 mGy/MBq) were much higher than those of brain

skin and thyroid (adult male: 0.000 3

0.000 5 and 0.000 5 mGy/MBq; adult female: 0.000 3

0.000 5 and 0.000 6 mGy/MBq). The range of absorbed dose coefficients of radiosensitive organs such as osteogenic cells

thymus and red marrow was 0.001 2-0.002 2 mGy/MBq. The absorbed dose coefficient of whole body was 0.001 7 mGy/MBq for adult male and 0.001 6 mGy/MBq for adult female. The effective dose coefficient of whole body was 0.004 58 mSv/MBq for adult male and 0.004 55 mSv/MBq for adult female. Conclusion:

99m

Tc-HYNIC-TOC is feasible to be used safely in human beings because the effective dose of whole body is lower than dose constraining. This study can provide the basis for using

99m

Tc-HYNIC-TOC safely in the clinical practice.

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99mTc-HYNIC-TOC人体内照射剂量研究

A study on the dose of99mTc-HYNIC-TOC in humans

DOI：10.19401/j.cnki.1007-3639.2020.11.004

摘要

Abstract

关键词

Keywords

references

^99mTc-HYNIC-TOC人体内照射剂量研究

A study on the dose of^99mTc-HYNIC-TOC in humans