新疆地区基于单位体检的低剂量CT筛查实践初探

张裔良; 刘丹玉; 朱朝晖; 常　炜; 闫晓刚; 靳永伟; 张　扬; 车　勇; 陈海泉

doi:10.19401/j.cnki.1007-3639.2020.12.007

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新疆地区基于单位体检的低剂量CT筛查实践初探

更新时间：2026-01-27

- 新疆地区基于单位体检的低剂量CT筛查实践初探
- Results of low-dose computed tomography as a regular health examination among Xinjiang hospital employees
- 中国癌症杂志 2020年30卷第12期页码：1008-1012
- 作者机构：
  
  1. 新疆医科大学第八附属医院胸外中心,新疆,乌鲁木齐,830000
  2. 复旦大学附属肿瘤医院胸外科，复旦大学胸部肿瘤研究所，复旦大学遗传工程国家重点实验室，
  3. 复旦大学上海医学院肿瘤学系,上海,200032
  4. 新疆医科大学第八附属医院公共卫生科,新疆,乌鲁木齐,830000
- 作者简介：
- 基金信息：
  
  国家卫生健康委医药卫生科技发展研究中心2019年度分中心项目（WA2020RW27）;国家自然科学基金（81930073）;上海市科技重大专项（2017SHZDZX01，VBH1323001/026）;上海市临床重点专科项目（SHSLCZDZK02104）;上海市浦江人才计划（2020PJD014）;复旦大学先导项目（IDF159034）。
- DOI：10.19401/j.cnki.1007-3639.2020.12.007
  中图分类号：
- 网络出版：2021-01-08，
  
  纸质出版：2021-01-08
- 稿件说明：
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张裔良 , 刘丹玉 , 朱朝晖 , 常　炜 , 闫晓刚 , 靳永伟 , 张　扬 , 车　勇 , 陈海泉 . 新疆地区基于单位体检的低剂量CT筛查实践初探[J]. 中国癌症杂志, 2020, 30(12): 1008-1012.

ZHANG Yiliang, LIU Danyu, ZHU Chaohui, et al. Results of low-dose computed tomography as a regular health examination among Xinjiang hospital employees[J]. China Oncology, 2020, 30(12): 1008-1012.
张裔良 , 刘丹玉 , 朱朝晖 , 常　炜 , 闫晓刚 , 靳永伟 , 张　扬 , 车　勇 , 陈海泉 . 新疆地区基于单位体检的低剂量CT筛查实践初探[J]. 中国癌症杂志, 2020, 30(12): 1008-1012. DOI： 10.19401/j.cnki.1007-3639.2020.12.007.

ZHANG Yiliang, LIU Danyu, ZHU Chaohui, et al. Results of low-dose computed tomography as a regular health examination among Xinjiang hospital employees[J]. China Oncology, 2020, 30(12): 1008-1012. DOI： 10.19401/j.cnki.1007-3639.2020.12.007.

摘要

背景与目的：中国东部地区低剂量CT（low-dose computed tomography，LDCT）筛查发现，之前认为的“低风险人群”，即不吸烟的年轻女性有较高的肺癌检出率。这种现象是否也见于中国西部地区，早期肺癌LDCT筛查的适宜对象如何确定尚不清楚。分析新疆健康人群筛查的检出数据，为进一步在肺癌筛查中推广LDCT提供实践依据。方法：2020年4月—2020年5月，新疆医科大学第八附属医院职工年度体检，提供免费的LDCT检查，全院在职和退休职工自愿参与。所有可疑影像资料均由本院胸部疾病多学科团队审定，给出进一步诊断、治疗或随访的建议。结果：LDCT筛查总人数1 039人，包括女性739人（71.1%），中位年龄35岁（19~90岁）。参与者中，汉族698人（67.2%）。LDCT检出肺部异常者351人（33.8%），检出率与年龄呈正相关（P0.001）。其中实性结节86例（8.3%）、磨玻璃结节12例（1.2%）、钙化病灶141例（13.5%）、其他良性病变112例（10.8%）。实性结节中确诊肺癌1例，为吸烟男性。接受手术切除者2例，1例实性结节经病理学检查证实为结核，1例磨玻璃病灶（最大径3 cm）是炎性病变。另有2例最大径8 mm的磨玻璃结节，在半年随访CT检查时发现病灶缩小，考虑为炎性病变。其余患者目前均未发现恶性证据。结论：LDCT作为体检项目在首次筛查的健康人群中查出相当比例的肺部异常病灶，其在新疆居民中是否可作为常规筛查手段需要进一步证实。

Abstract

Background and purpose: Low-dose computed tomography (LDCT) screening in Eastern China has found that the previously considered “low-risk population”

that is

young women who do not smoke

have a higher detection rate of lung cancer. Whether this phenomenon also exists in Western China

and how to determine the target receivers for LDCT is still unknown. This study analyzed the data of the screening of some residents in Xinjiang Uygur Autonomous Region and provided a practical basis for promoting practice of LDCT. Methods: From Apr. 2020 to May 2020

all employees of the Eighth Affiliated Hospital of Xinjiang Medical University voluntarily underwent free LDCT screenings as one of their annual health examinations

including retired employees. All suspicious imaging data were reviewed by the multidisciplinary team of chest diseases in the hospital

and recommendations for clinical diagnosis

treatment

or follow-up were given. Results: A total of 1 039 employees underwent LDCT

including 739 (71.1%) women

with a median age of 35 years (19-90 years). Among the participants

698 (67.2%) were of Han ethnicity. LDCT showed 351 (33.8%) cases with lung abnormalities. The detection rate was positively correlated with age (P0.001). Among these abnormal cases

86 (8.3%) were solid nodules

12 (1.2%) were ground-glass opacities (GGO)

141 (13.5%) were calcified lesions

and 112 (10.8%) cases of other benign lesions. One case of lung cancer was finally diagnosed

and he was a male smoker . Two cases underwent surgical resection. Pathological diagnosis confirmed that one solid nodule was tuberculosis

and one GGO (maximum diameter was 3 cm) was an inflammatory lesion. In the other two cases of GGO with a diameter greater than 8 mm

the lesions were found to shrink during the half-year follow-up CT scan

considering inflammatory lesions as well. No evidence of malignancy had been found in the remaining patients until this manuscript was complete. Conclusion: LDCT as a regular health examination detects a considerable proportion of healthy population with lung abnormalities. How it can be used as a routine screening method among Xinjiang residents needs further investigation.

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