Background and purpose: Concurrent chemoradiotherapy is the preferred treatment for locally advanced nasopharyngeal carcinoma. However

concurrent chemoradiotherapy will worsen the nutritional status of patients

thus affecting the quality of life and survival prognosis of patients. This study aimed to investigate the effect of individualized nutritional intervention based on nutritional risk assessment on quality of life and survival prognosis of patients with locally advanced nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy. Methods: A total of 116 patients with locally advanced nasopharyngeal carcinoma treated in the Second Affiliated Hospital of Hainan Medical College from January 2017 to March 2019 were enrolled and randomly divided into the intervention group (58 cases) and the control group (58 cases). The patients in both groups were treated with the same concurrent chemoradiotherapy. The control group received routine dietary guidance

and the intervention group received individualized nutritional intervention based on nutritional risk assessment during concurrent chemoradiotherapy. The nutritional status and life quality of the two groups were compared

and the 2-year and 3-year overall survival (OS)

local recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) of the two groups were analyzed. Results: The incidence of malnutrition in the intervention group at 2 weeks

4 weeks and the end of radiotherapy was 27.59%

46.55% and 51.72% respectively

which were lower than 48.28%

75.86% and 81.03% of the control group (P ＜ 0.05). After treatment

scores of life quality including psychological function

role function

cognitive function

emotional function

social function were significantly higher in the intervention group than in the control group (P ＜ 0.05). The 2-year and 3-year OS

LRFS and DMFS were higher in the intervention group than in the control group (P ＜ 0.05). Conclusion: Individualized nutrition intervention can effectively improve the nutritional status

life quality and the survival prognosis of locally advanced nasopharyngeal carcinoma patients during concurrent chemoradiotherapy.