
浏览全部资源
扫码关注微信
上海交通大学医学院附属瑞金医院放射治疗科,上海 200025
[ "蔡钢(ORCID: 0000-0001-8071-4422),博士,副主任医师,E-mail: caigangcg@163.com。" ]
[ "陈佳艺,上海交通大学医学院附属瑞金医院放射治疗科主任、主任医师,上海交通大学肿瘤学博士研究生导师。长期致力于肿瘤放疗的临床和转化型研究,尤其擅长乳腺癌、胃肠道肿瘤、恶性淋巴瘤等的放疗和综合治疗,是国内最早开展粒子治疗研究的学者之一。长期从事上海市放疗质控中心专家组的工作,对数字化和信息化管理及质控管理有深入的研究。目前担任上海市医学会肿瘤放射治疗专业委员会候任主任委员,中国抗癌协会整合肿瘤心脏病学专业委员会副主任委员,中国临床肿瘤学会神经系统肿瘤专家委员会副主任委员,中国临床肿瘤学会乳腺癌专家委员会常委,中国临床肿瘤学会肿瘤放射治疗专家委员会常委。曾获得2018年度上海市三八红旗手,2019年度上海市最美女医师,2019年度上海市巾帼建功标兵。“中国临床肿瘤学会乳腺癌诊疗指南”放疗部分执笔人,并参与编写国内多个乳腺癌放疗指南。以项目负责人身份先后承担国家自然科学基金面上项目2项,科技部重大项目子课题1项,省部级课题2项,申康“三年行动计划”项目2项,上海市局级课题1项。以第一作者或通信作者在国内权威、核心和SCI收录期刊上发表论文70余篇。" ]
收稿:2022-06-02,
纸质出版:2022-07-30
移动端阅览
蔡钢, 王舒蓓, 陈佳艺. 放射治疗在胃癌全程管理中的现状与挑战[J]. 中国癌症杂志, 2022,32(7):581-587.
Gang CAI, Shubei WANG, Jiayi CHEN. The current data and challenge of radiotherapy in the case management of gastric cancer[J]. China Oncology, 2022, 32(7): 581-587.
蔡钢, 王舒蓓, 陈佳艺. 放射治疗在胃癌全程管理中的现状与挑战[J]. 中国癌症杂志, 2022,32(7):581-587. DOI: 10.19401/j.cnki.1007-3639.2022.07.001.
Gang CAI, Shubei WANG, Jiayi CHEN. The current data and challenge of radiotherapy in the case management of gastric cancer[J]. China Oncology, 2022, 32(7): 581-587. DOI: 10.19401/j.cnki.1007-3639.2022.07.001.
胃癌是常见的消化道恶性肿瘤之一。放疗是胃癌综合治疗的重要手段之一。近年来
包括放疗在内的局部进展期胃癌的围手术期治疗的探索不断取得突破
这些疗法对胃癌患者生存的积极影响也越来越明显。近年来在胃癌的新辅助放疗、辅助放疗、进展期肿瘤放疗及免疫联合放疗领域均有新的研究成果。本文深入分析国内外的相关研究进展
系统阐述放疗在胃癌治疗中的应用现状与进展。
Gastric cancer is one of the common malignant tumors of digestive tract. Radiotherapy is one of the important comprehensive treatment modalities for patients with gastric cancer. In recent years
there have been breakthroughs in perioperative treatment for locally advanced gastric cancer by radiotherapy and other treatments. The positive impact of such therapies on survival in patients with gastric cancer has become clearer over time. In recent years
new achievements have been made in the fields of neoadjuvant radiotherapy
adjuvant radiotherapy
advanced tumor radiotherapy and combined immunoradiotherapy for gastric cancer. This article analyzed the relevant research progress at home and abroad
and systematically expounded the current status and progress of radiotherapy in the treatment of gastric cancer.
ZHENG R , ZHANG S , ZENG H , et al . Cancer incidence and mortality in China, 2016 [J ] . J Natl Cancer Cent , 2022 , 2 ( 1 ): 1 - 9 .
LANDRY J , TEPPER J E , WOOD W C , et al . Patterns of failure following curative resection of gastric carcinoma [J ] . Int J Radiat Oncol Biol Phys , 1990 , 19 ( 6 ): 1357 - 1362 . DOI: 10.1016/0360-3016(90)90344-J http://doi.org/10.1016/0360-3016(90)90344-J https://linkinghub.elsevier.com/retrieve/pii/036030169090344J https://linkinghub.elsevier.com/retrieve/pii/036030169090344J
VAN HAGEN P , HULSHOF M C , VAN LANSCHOT J J , et al . Preoperative chemoradiotherapy for esophageal or junctional cancer [J ] . N Engl J Med , 2012 , 366 ( 22 ): 2074 - 2084 . DOI: 10.1056/NEJMoa1112088 http://doi.org/10.1056/NEJMoa1112088 http://www.nejm.org/doi/10.1056/NEJMoa1112088 http://www.nejm.org/doi/10.1056/NEJMoa1112088
STAHL M , WALZ M K , RIERA-KNORRENSCHILD J , et al . Preoperative chemotherapy versus chemoradiotherapy in locally advanced adenocarcinomas of the oesophagogastric junction (POET): long-term results of a controlled randomised trial [J ] . Eur J Cancer , 2017 , 81 : 183 - 190 . DOI: 10.1016/j.ejca.2017.04.027 http://doi.org/10.1016/j.ejca.2017.04.027 https://linkinghub.elsevier.com/retrieve/pii/S0959804917309541 https://linkinghub.elsevier.com/retrieve/pii/S0959804917309541
LEONG T , SMITHERS B M , HAUSTERMANS K , et al . TOPGEAR: a randomized, phase Ⅲ trial of perioperative ECF chemotherapy with or without preoperative chemoradiation for resectable gastric cancer: interim results from an international, intergroup trial of the AGITG, TROG, EORTC and CCTG [J ] . Ann Surg Oncol , 2017 , 24 ( 8 ): 2252 - 2258 . DOI: 10.1245/s10434-017-5830-6 http://doi.org/10.1245/s10434-017-5830-6 http://link.springer.com/10.1245/s10434-017-5830-6 http://link.springer.com/10.1245/s10434-017-5830-6
AJANI J A , WINTER K , OKAWARA G S , et al . Phase Ⅱ trial of preoperative chemoradiation in patients with localized gastric adenocarcinoma (RTOG 9904): quality of combined modality therapy and pathologic response [J ] . J Clin Oncol , 2006 , 24 ( 24 ): 3953 - 3958 . DOI: 10.1200/JCO.2006.06.4840 http://doi.org/10.1200/JCO.2006.06.4840 https://ascopubs.org/doi/10.1200/JCO.2006.06.4840 https://ascopubs.org/doi/10.1200/JCO.2006.06.4840
AJANI J A , MANSFIELD P F , JANJAN N , et al . Multi-institutional trial of preoperative chemoradiotherapy in patients with potentially resectable gastric carcinoma [J ] . J Clin Oncol , 2004 , 22 ( 14 ): 2774 - 2780 . DOI: 10.1200/JCO.2004.01.015 http://doi.org/10.1200/JCO.2004.01.015 https://ascopubs.org/doi/10.1200/JCO.2004.01.015 https://ascopubs.org/doi/10.1200/JCO.2004.01.015
AJANI J A , MANSFIELD P F , CRANE C H , et al . Paclitaxel-based chemoradiotherapy in localized gastric carcinoma: degree of pathologic response and not clinical parameters dictated patient outcome [J ] . J Clin Oncol , 2005 , 23 ( 6 ): 1237 - 1244 . DOI: 10.1200/JCO.2005.01.305 http://doi.org/10.1200/JCO.2005.01.305 https://ascopubs.org/doi/10.1200/JCO.2005.01.305 https://ascopubs.org/doi/10.1200/JCO.2005.01.305
WANG F H , ZHANG X T , LI Y F , et al . The Chinese Society of Clinical Oncology (CSCO): clinical guidelines for the diagnosis and treatment of gastric cancer, 2021 [J ] . Cancer Commun (Lond) , 2021 , 41 ( 8 ): 747 - 795 .
MACDONALD J S , SMALLEY S R , BENEDETTI J , et al . Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction [J ] . N Engl J Med , 2001 , 345 ( 10 ): 725 - 730 . DOI: 10.1056/NEJMoa010187 http://doi.org/10.1056/NEJMoa010187 http://www.nejm.org/doi/abs/10.1056/NEJMoa010187 http://www.nejm.org/doi/abs/10.1056/NEJMoa010187
SMALLEY S R , BENEDETTI J K , HALLER D G , et al . Updated analysis of SWOG-directed intergroup study 0116: a phase Ⅲ trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection [J ] . J Clin Oncol , 2012 , 30 ( 19 ): 2327 - 2333 . DOI: 10.1200/JCO.2011.36.7136 http://doi.org/10.1200/JCO.2011.36.7136 https://ascopubs.org/doi/10.1200/JCO.2011.36.7136 https://ascopubs.org/doi/10.1200/JCO.2011.36.7136
DIKKEN J L , JANSEN E P M , CATS A , et al . Impact of the extent of surgery and postoperative chemoradiotherapy on recurrence patterns in gastric cancer [J ] . J Clin Oncol , 2010 , 28 ( 14 ): 2430 - 2436 . DOI: 10.1200/JCO.2009.26.9654 http://doi.org/10.1200/JCO.2009.26.9654 https://ascopubs.org/doi/10.1200/JCO.2009.26.9654 https://ascopubs.org/doi/10.1200/JCO.2009.26.9654
STIEKEMA J , TRIP A K , JANSEN E P M , et al . The prognostic significance of an R1 resection in gastric cancer patients treated with adjuvant chemoradiotherapy [J ] . Ann Surg Oncol , 2014 , 21 ( 4 ): 1107 - 1114 . DOI: 10.1245/s10434-013-3397-4 http://doi.org/10.1245/s10434-013-3397-4 http://link.springer.com/10.1245/s10434-013-3397-4 http://link.springer.com/10.1245/s10434-013-3397-4
PARK S H , SOHN T S , LEE J , et al . Phase Ⅲ trial to compare adjuvant chemotherapy with capecitabine and cisplatin versus concurrent chemoradiotherapy in gastric cancer: final report of the adjuvant chemoradiotherapy in stomach tumors trial, including survival and subset analyses [J ] . J Clin Oncol , 2015 , 33 ( 28 ): 3130 - 3136 . DOI: 10.1200/JCO.2014.58.3930 http://doi.org/10.1200/JCO.2014.58.3930 https://ascopubs.org/doi/10.1200/JCO.2014.58.3930 https://ascopubs.org/doi/10.1200/JCO.2014.58.3930
ZHU W G , XUA D F , PU J , et al . A randomized, controlled, multicenter study comparing intensity-modulated radiotherapy plus concurrent chemotherapy with chemotherapy alone in gastric cancer patients with D2 resection [J ] . Radiother Oncol , 2012 , 104 ( 3 ): 361 - 366 . DOI: 10.1016/j.radonc.2012.08.024 http://doi.org/10.1016/j.radonc.2012.08.024 https://linkinghub.elsevier.com/retrieve/pii/S0167814012003751 https://linkinghub.elsevier.com/retrieve/pii/S0167814012003751
PARK S H , LIM D H , SOHN T S , et al . A randomized phase Ⅲ trial comparing adjuvant single-agent S1, S-1 with oxaliplatin, and postoperative chemoradiation with S-1 and oxaliplatin in patients with node-positive gastric cancer after D2 resection: the ARTIST 2 trial [J ] . Ann Oncol , 2021 , 32 ( 3 ): 368 - 374 . DOI: 10.1016/j.annonc.2020.11.017 http://doi.org/10.1016/j.annonc.2020.11.017 https://linkinghub.elsevier.com/retrieve/pii/S0923753420431722 https://linkinghub.elsevier.com/retrieve/pii/S0923753420431722
CATS A , JANSEN E P M , VAN GRIEKEN N C T , et al . Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial [J ] . Lancet Oncol , 2018 , 19 ( 5 ): 616 - 628 . DOI: 10.1016/S1470-2045(18)30132-3 http://doi.org/10.1016/S1470-2045(18)30132-3 https://linkinghub.elsevier.com/retrieve/pii/S1470204518301323 https://linkinghub.elsevier.com/retrieve/pii/S1470204518301323
DE STEUR W O , VAN AMELSFOORT R M , HARTGRINK H H , et al . Adjuvant chemotherapy is superior to chemoradiation after D2 surgery for gastric cancer in the per-protocol analysis of the randomized CRITICS trial [J ] . Ann Oncol , 2021 , 32 ( 3 ): 360 - 367 . DOI: 10.1016/j.annonc.2020.11.004 http://doi.org/10.1016/j.annonc.2020.11.004 https://linkinghub.elsevier.com/retrieve/pii/S0923753420431564 https://linkinghub.elsevier.com/retrieve/pii/S0923753420431564
YU C , YU R , ZHU W , et al . Intensity-modulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard D1/D2 surgery [J ] . J Cancer Res Clin Oncol , 2012 , 138 ( 2 ): 255 - 259 . DOI: 10.1007/s00432-011-1085-y http://doi.org/10.1007/s00432-011-1085-y http://link.springer.com/10.1007/s00432-011-1085-y http://link.springer.com/10.1007/s00432-011-1085-y
DAI Q , JIANG L , LIN R J , et al . Adjuvant chemoradiotherapy versus chemotherapy for gastric cancer: a meta-analysis of randomized controlled trials [J ] . J Surg Oncol , 2015 , 111 ( 3 ): 277 - 284 . DOI: 10.1002/jso.23795 http://doi.org/10.1002/jso.23795 https://onlinelibrary.wiley.com/doi/10.1002/jso.23795 https://onlinelibrary.wiley.com/doi/10.1002/jso.23795
PENG J , WEI Y H , ZHOU F X , et al . D2-resected stage Ⅲc gastric cancer patients benefit from adjuvant chemoradiotherapy [J ] . Cancer Med , 2016 , 5 ( 10 ): 2773 - 2780 . DOI: 10.1002/cam4.873 http://doi.org/10.1002/cam4.873 https://onlinelibrary.wiley.com/doi/10.1002/cam4.873 https://onlinelibrary.wiley.com/doi/10.1002/cam4.873
FAN M , LI G C , SHEN L J , et al . Identification of patients with lymph node metastasis from gastric cancer who may benefit from adjuvant chemoradiotherapy after D2 dissection: do N3 patients benefit from additional radiation? [J ] . Br J Radiol , 2016 , 89 ( 1059 ): 20150758.
ZHOU M L , YANG W , WANG Y Q , et al . Adjuvant chemoradiotherapy versus adjuvant chemotherapy for patients with N3 gastric cancer after D2/R0 resection: a retrospective study based on propensity score analyses [J ] . Cancer Manag Res , 2019 , 11 : 4855 - 4870 . DOI: 10.2147/CMAR.S195130 http://doi.org/10.2147/CMAR.S195130 https://www.dovepress.com/adjuvant-chemoradiotherapy-versus-adjuvant-chemotherapy-for-patients-w-peer-reviewed-article-CMAR https://www.dovepress.com/adjuvant-chemoradiotherapy-versus-adjuvant-chemotherapy-for-patients-w-peer-reviewed-article-CMAR
SMYTH E C , VERHEIJ M , ALLUM W , et al . Gastric cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up [J ] . Ann Oncol , 2016 , 27 : v38 -v49. DOI: 10.1093/annonc/mdw350 http://doi.org/10.1093/annonc/mdw350 https://linkinghub.elsevier.com/retrieve/pii/S0923753419316485 https://linkinghub.elsevier.com/retrieve/pii/S0923753419316485
AJANI J A , D’AMICO T A , BENTREM D J , et al . Gastric cancer, version 2.2022, NCCN clinical practice guidelines in oncology [J ] . J Natl Compr Canc Netw , 2022 , 20 ( 2 ): 167 - 192 . DOI: 10.6004/jnccn.2022.0008 http://doi.org/10.6004/jnccn.2022.0008 https://jnccn.org/view/journals/jnccn/20/2/article-p167.xml https://jnccn.org/view/journals/jnccn/20/2/article-p167.xml
WANG S B , QI W X , CHEN J Y , et al . Competing risk nomogram predicting initial loco-regional recurrence in gastric cancer patients after D2 gastrectomy [J ] . Radiat Oncol , 2019 , 14 ( 1 ): 128 . DOI: 10.1186/s13014-019-1332-y http://doi.org/10.1186/s13014-019-1332-y https://doi.org/10.1186/s13014-019-1332-y https://doi.org/10.1186/s13014-019-1332-y
LI F X , ZHANG R P , LIANG H , et al . The pattern and risk factors of recurrence of proximal gastric cancer after curative resection [J ] . J Surg Oncol , 2013 , 107 ( 2 ): 130 - 135 . DOI: 10.1002/jso.23252 http://doi.org/10.1002/jso.23252 https://onlinelibrary.wiley.com/doi/10.1002/jso.23252 https://onlinelibrary.wiley.com/doi/10.1002/jso.23252
KARPEH M S , LEON L , KLIMSTRA D , et al . Lymph node staging in gastric cancer: is location more important than Number? An analysis of 1 038 patients [J ] . Ann Surg , 2000 , 232 ( 3 ): 362 - 371 . DOI: 10.1097/00000658-200009000-00008 http://doi.org/10.1097/00000658-200009000-00008 http://journals.lww.com/00000658-200009000-00008 http://journals.lww.com/00000658-200009000-00008
NAM H , LIM D H , KIM S , et al . A new suggestion for the radiation target volume after a subtotal gastrectomy in patients with stomach cancer [J ] . Int J Radiat Oncol Biol Phys , 2008 , 71 ( 2 ): 448 - 455 . DOI: 10.1016/j.ijrobp.2007.09.055 http://doi.org/10.1016/j.ijrobp.2007.09.055 https://linkinghub.elsevier.com/retrieve/pii/S0360301607044409 https://linkinghub.elsevier.com/retrieve/pii/S0360301607044409
ZHU H T , ZHAO Y L , WU Y F , et al . Features of metastasis in different lymph node groups and their significance in lymph node dissection in total gastrectomy for gastric cancer [J ] . Chin J Oncol , 2008 , 30 ( 11 ): 863 - 865 .
YU J I , LIM D H , AHN Y C , et al . Effects of adjuvant radiotherapy on completely resected gastric cancer: a radiation oncologist’s view of the artist randomized phase Ⅲ trial [J ] . Radiother Oncol , 2015 , 117 ( 1 ): 171 - 177 . DOI: 10.1016/j.radonc.2015.08.009 http://doi.org/10.1016/j.radonc.2015.08.009 https://linkinghub.elsevier.com/retrieve/pii/S016781401500434X https://linkinghub.elsevier.com/retrieve/pii/S016781401500434X
CHANG J S , LIM J S , NOH S H , et al . Patterns of regional recurrence after curative D2 resection for stage Ⅲ (N3) gastric cancer: implications for postoperative radiotherapy [J ] . Radiother Oncol , 2012 , 104 ( 3 ): 367 - 373 . DOI: 10.1016/j.radonc.2012.08.017 http://doi.org/10.1016/j.radonc.2012.08.017 https://linkinghub.elsevier.com/retrieve/pii/S0167814012003684 https://linkinghub.elsevier.com/retrieve/pii/S0167814012003684
YOON H I , CHANG J S , LIM J S , et al . Defining the target volume for post-operative radiotherapy after D2 dissection in gastric cancer by CT-based vessel-guided delineation [J ] . Radiother Oncol , 2013 , 108 ( 1 ): 72 - 77 . DOI: 10.1016/j.radonc.2013.05.025 http://doi.org/10.1016/j.radonc.2013.05.025 https://linkinghub.elsevier.com/retrieve/pii/S0167814013002454 https://linkinghub.elsevier.com/retrieve/pii/S0167814013002454
CHANG J S , KIM K H , YOON H I , et al . Locoregional relapse after gastrectomy with D2 lymphadenectomy for gastric cancer [J ] . Br J Surg , 2017 , 104 ( 7 ): 877 - 884 . DOI: 10.1002/bjs.10502 http://doi.org/10.1002/bjs.10502 https://academic.oup.com/bjs/article/104/7/877/6095127 https://academic.oup.com/bjs/article/104/7/877/6095127
李桂超 , 章真 , 马学军 , 等 . 胃癌根治术后局部或区域性复发部位规律及复发后放疗疗效在确定术后放疗靶区中的意义 [J ] . 肿瘤 , 2012 , 32 ( 10 ): 794 - 799 .
LI G C , ZHANG Z , MA X J , et al . The value of patterns of loco-regional recurrence of gastric cancer after curative resection and efficacy of radiation therapy for cancer recurrence in target definition in postoperative radiotherapy [J ] . Tumor , 2012 , 32 ( 10 ): 794 - 799 .
WANG S B , QI W X , CHEN J Y , et al . Identification of patients with locally advanced gastric cancer who may benefit from adjuvant chemoradiotherapy after D2 dissection: a propensity score matching analysis [J ] . Front Oncol , 2021 , 11 : 648978.
中国医师协会放射肿瘤治疗医师分会 , 中华医学会放射肿瘤治疗学分会 , 中国抗癌协会肿瘤放疗专业委员会 . 中国胃癌放疗指南(2020版) [J ] . 中华放射肿瘤学杂志 , 2021 , 30 ( 10 ): 989 - 1001 .
Society of Radiation Oncologists, Chinese Medical Doctor Association ; Society of Radiation Oncology, Chinese Medical Association ; Professional Committee on Oncology Radiotherapy, Chinese Anti-Cancer Association . Radiotherapy guidelines for gastric cancer in China (2020ed) [J ] . Chin J Radiat Oncol , 2021 , 30 ( 10 ): 989 - 1001 .
SAIKAWA Y , KUBOTA T , KUMAGAI K , et al . Phase Ⅱ study of chemoradiotherapy with S-1 and low-dose cisplatin for inoperable advanced gastric cancer [J ] . Int J Radiat Oncol Biol Phys , 2008 , 71 ( 1 ): 173 - 179 . DOI: 10.1016/j.ijrobp.2007.09.010 http://doi.org/10.1016/j.ijrobp.2007.09.010 https://linkinghub.elsevier.com/retrieve/pii/S0360301607042046 https://linkinghub.elsevier.com/retrieve/pii/S0360301607042046
AJANI J A , KOMAKI R , PUTNAM J B , et al . A three-step strategy of induction chemotherapy then chemoradiation followed by surgery in patients with potentially resectable carcinoma of the esophagus or gastroesophageal junction [J ] . Cancer , 2001 , 92 ( 2 ): 279 - 286 . DOI: 10.1002/1097-0142(20010715)92:2<279::AID-CNCR1320>3.0.CO;2-2 http://doi.org/10.1002/1097-0142(20010715)92:2<279::AID-CNCR1320>3.0.CO;2-2 https://onlinelibrary.wiley.com/doi/10.1002/1097-0142(20010715)92:2<279::AID-CNCR1320>3.0.CO;2-2 https://onlinelibrary.wiley.com/doi/10.1002/1097-0142(20010715)92:2<279::AID-CNCR1320>3.0.CO;2-2
XU C P , XIE J , LIANG N , et al . Concurrent involved-field radiotherapy and XELOX in gastric cancer patients with postoperative oligometastatic recurrence [J ] . J Cancer Res Ther , 2014 , 10 Suppl : 267 - 271 .
YUAN S T , WANG F L , LIU N , et al . Concurrent involved-field radiotherapy and xelox versus xelox chemotherapy alone in gastric cancer patients with postoperative locoregional recurrence [J ] . Am J Clin Oncol , 2015 , 38 ( 2 ): 130 - 134 . DOI: 10.1097/COC.0b013e31828f5cb6 http://doi.org/10.1097/COC.0b013e31828f5cb6 https://journals.lww.com/00000421-201504000-00002 https://journals.lww.com/00000421-201504000-00002
WEI J , LU X F , LIU Q , et al . Efficacy and safety of sintilimab in combination with concurrent chemoradiotherapy for locally advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma (SHARED): study protocol of a prospective, multi-center, single-arm phase 2 trial [J ] . Cancer Manag Res , 2022 , 14 : 2007 - 2015 . DOI: 10.2147/CMAR.S355687 http://doi.org/10.2147/CMAR.S355687 https://www.dovepress.com/efficacy-and-safety-of-sintilimab-in-combination-with-concurrent-chemo-peer-reviewed-fulltext-article-CMAR https://www.dovepress.com/efficacy-and-safety-of-sintilimab-in-combination-with-concurrent-chemo-peer-reviewed-fulltext-article-CMAR
0
浏览量
1673
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621