CPCC晚期前列腺癌中国专家共识——转移性激素敏感性前列腺癌起始应用新型内分泌治疗的全程管理（2022年版）

中国前列腺癌研究协作组（CPCC）; 叶定伟; 黄健

doi:10.19401/j.cnki.1007-3639.2022.12.013

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CPCC晚期前列腺癌中国专家共识——转移性激素敏感性前列腺癌起始应用新型内分泌治疗的全程管理（2022年版）

指南与共识 | 更新时间：2025-12-31

- CPCC晚期前列腺癌中国专家共识——转移性激素敏感性前列腺癌起始应用新型内分泌治疗的全程管理（2022年版）
- Chinese Prostate Cancer Consortium (CPCC) Chinese expert consensus on advanced prostate cancer: clinical management of patients with metastatic hormone-sensitive prostate cancer treated by initial novel hormone therapy (2022 edition)
- 中国癌症杂志 2022年32卷第12期页码：1242-1258
- 作者机构：
  
  1. 复旦大学附属肿瘤医院泌尿外科，复旦大学上海医学院肿瘤学系，上海 200032
  2. 中山大学孙逸仙纪念医院泌尿外科，广东广州 510060
- 作者简介：
  
  叶定伟（ORCID ：0000-0003-4974-3780），博士，主任医师、教授，复旦大学附属肿瘤医院党委副书记、泌尿肿瘤多学科诊治团队首席专家；
  黄健（ORCID：0000-0002-1296-9316），博士，主任医师、教授，中山大学孙逸仙纪念医院泌尿外科主任。
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2022.12.013
  中图分类号： R737.25
- 收稿：2022-10-14，
  
  修回：2022-10-30，
  
  纸质出版：2022-12-30
- 稿件说明：
移动端阅览
中国前列腺癌研究协作组（CPCC）, 叶定伟, 黄健. CPCC晚期前列腺癌中国专家共识——转移性激素敏感性前列腺癌起始应用新型内分泌治疗的全程管理（2022年版）[J]. 中国癌症杂志, 2022,32(12):1242-1258.

Prostate Cancer Consortium (CPCC) Chinese, Dingwei YE, Jian HUANG. Chinese Prostate Cancer Consortium (CPCC) Chinese expert consensus on advanced prostate cancer: clinical management of patients with metastatic hormone-sensitive prostate cancer treated by initial novel hormone therapy (2022 edition)[J]. China Oncology, 2022, 32(12): 1242-1258.
中国前列腺癌研究协作组（CPCC）, 叶定伟, 黄健. CPCC晚期前列腺癌中国专家共识——转移性激素敏感性前列腺癌起始应用新型内分泌治疗的全程管理（2022年版）[J]. 中国癌症杂志, 2022,32(12):1242-1258. DOI： 10.19401/j.cnki.1007-3639.2022.12.013.

Prostate Cancer Consortium (CPCC) Chinese, Dingwei YE, Jian HUANG. Chinese Prostate Cancer Consortium (CPCC) Chinese expert consensus on advanced prostate cancer: clinical management of patients with metastatic hormone-sensitive prostate cancer treated by initial novel hormone therapy (2022 edition)[J]. China Oncology, 2022, 32(12): 1242-1258. DOI： 10.19401/j.cnki.1007-3639.2022.12.013.

摘要

转移性激素敏感性前列腺癌（metastatic hormone-sensitive prostate cancer，mHSPC）是需要持续关注的男性健康问题。2021年国内外各大指南关于mHSPC初始系统治疗推荐进行了重要更新，新型内分泌治疗（novel hormone therapy，NHT）联合雄激素剥夺治疗（androgen deprivation therapy，ADT）成为最重要的系统治疗方案。同时转移性前列腺癌原发灶局部治疗、转移灶定向治疗（metastasis-directed therapy，MDT）、基因检测、新型影像学（next-generation imaging，NGI）等新技术、新理念快速发展，推动mHSPC全程诊疗格局进一步改变。中国与欧美地区前列腺癌在遗传背景、早筛开展、初诊疾病分布及临床表现等方面均存在明显差异，为解答中国mHSPC临床管理相关的热点及争议问题，由中国前列腺癌研究协作组（Chinese Prostate Cancer Consortium，CPCC）组织多学科专家筛选关键决策问题，结合最新发表数据，经过多轮投票及讨论，最终形成《CPCC晚期前列腺癌中国专家共识——转移性激素敏感性前列腺癌起始应用新型内分泌治疗的全程管理（2022年版）》，以期为mHSPC真实世界临床管理提供决策参考。

Abstract

Metastatic hormone-sensitive prostate cancer (mHSPC) is a male health concern requiring continuous attention. In 2021

an important update was included in domestic and international guidelines regarding the recommendations of initial systemic therapy for mHSPC

in which androgen deprivation therapy (ADT) combined with novel hormone therapy (NHT) has became the most important systemic treatment strategy. Meanwhile

emerging technologies and concepts

such as local therapy for the primary tumor in mHSPC

metastasis-directed therapy (MDT)

genetic testing

and next generation imaging (NGI)

have developed rapidly to promote further changes in the pattern of diagnosis and treatment of mHSPC. There are significant differences observed between China and western countries including genetics

screening policy

disease stage distribution and clinical characteristics at diagnosis. Focus on the controversial issues related to the clinical management of mHSPC in China

Chinese Prostate Cancer Consortium (CPCC) organized multidisciplinary experts to screen key decision-making questions based on the latest evidence. After multiple rounds of voting and discussion

the “Chinese Prostate Cancer Consortium (CPCC) Chinese expert consensus on advanced prostate cancer: clinical management of patients with metastatic hormone-sensitive prostate cancer treated by initial novel hormone therapy (2022 edition)” is finally formed

aiming to provide a decision-making reference for clinical management of mHSPC in the real-world.

关键词

Keywords

references

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