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三阳性乳腺癌内分泌治疗联合靶向治疗的研究进展
The research progress of endocrine therapy combined with targeted therapy for triple-positive breast cancer
- 中国癌症杂志 2023年33卷第3期 页码：288-292
- 作者机构：
山东省肿瘤防治研究院（山东省肿瘤医院），山东第一医科大学（山东省医学科学院），乳腺病中心，山东 济南 250117
- 作者简介：
[ "曹晓珊（ORCID: 0000-0003-3959-6780），博士，主治医师。" ]
丛斌斌（ORCID: 0000-0002-8026-2988），博士，副主任医师。
- 基金信息：
DOI：10.19401/j.cnki.1007-3639.2023.03.013
中图分类号： R737.9收稿：2022-06-28，
修回：2022-12-30，
纸质出版：2023-03-30
- 稿件说明：
移动端阅览
曹晓珊 综述, 丛斌斌 审校. 三阳性乳腺癌内分泌治疗联合靶向治疗的研究进展[J]. 中国癌症杂志, 2023,33(3):288-292.
Xiaoshan CAO, Binbin CONG. The research progress of endocrine therapy combined with targeted therapy for triple-positive breast cancer[J]. China Oncology, 2023, 33(3): 288-292.
曹晓珊 综述, 丛斌斌 审校. 三阳性乳腺癌内分泌治疗联合靶向治疗的研究进展[J]. 中国癌症杂志, 2023,33(3):288-292. DOI： 10.19401/j.cnki.1007-3639.2023.03.013.
Xiaoshan CAO, Binbin CONG. The research progress of endocrine therapy combined with targeted therapy for triple-positive breast cancer[J]. China Oncology, 2023, 33(3): 288-292. DOI： 10.19401/j.cnki.1007-3639.2023.03.013.
摘要
三阳性乳腺癌（triple-positive breast cancer，TPBC）是指雌激素受体、孕激素受体和人表皮生长因子受体2（human epidermal growth factor receptor 2，HER2）表达均为阳性的乳腺癌，占所有乳腺癌病理学类型的5%~10%。TPBC是Luminal B型乳腺癌亚型的一种特殊类型，既可以接受内分泌治疗，又可以接受靶向治疗。目前国内外指南推荐TPBC的治疗首选抗HER2靶向治疗联合化疗，但TPBC新辅助治疗的病理学完全缓解率却低于激素受体阴性/HER2阳性乳腺癌，且雌激素受体表达>30%的患者从抗HER2靶向治疗联合化疗中获益较小。目前随着多种抗HER2靶向药物不断问世，以及细胞周期蛋白依赖性激酶4和6抑制剂的临床应用，使得临床上对于高选择的患者首选靶向治疗联合内分泌治疗成为可能。本文就TPBC内分泌治疗联合靶向治疗的最新研究进展进行综述。
Abstract
Triple-positive breast cancer (TPBC) refers to breast cancer with positive expression of estrogen receptor
progesterone receptor and human epidermal growth factor receptor 2 (HER2)
accounting for 5%-10% of all pathological types of breast cancer. TPBC is a special subtype of Luminal B breast cancer
which can receive both endocrine therapy and targeted therapy. TPBC is a special subtype of Luminal B breast cancer
which can receive both endocrine therapy and targeted therapy. The current guidelines recommend that anti-HER2-targeted therapy combined with chemotherapy is the first choice for TPBC treatment. However
the pathological complete response rate of TPBC is lower than that of hormone receptor negative/HER2-positive breast cancer. Moreover
patients with estrogen receptor expression >30% benefit less from anti-HER2-targeted therapy combined with chemotherapy. With the advent of various anti-HER2 targeted drugs and the clinical application of cyclin-dependent kinase 4 and 6 inhibitors
the combination of targeted therapy and endocrine therapy becomes possible for highly selected patients. This article reviewed the research progress of TPBC endocrine therapy combined with targeted therapy.
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references
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