
浏览全部资源
扫码关注微信
复旦大学附属肿瘤医院头颈外科,复旦大学上海医学院肿瘤学系,上海 200032
[ "渠宁(ORCID: 0000-0001-5670-4451),博士,副主任医师。" ]
[ "王宇,主任医师,博士研究生导师,复旦大学附属肿瘤医院头颈外科主任。擅长头颈部常见良恶性肿瘤的手术治疗及综合治疗。致力于甲状腺及头颈部肿瘤腔镜和机器人手术,保留功能的喉、喉咽手术,口腔癌、局部晚期甲状腺癌等头颈部肿瘤术后缺损的修复与重建,晚期甲状腺癌、头颈部恶性肿瘤的综合治疗及探索性治疗。作为主持及主要参与者参加30余项国家级、省级、市局级及国际多中心基础及临床试验。主持多项甲状腺癌、头颈部肿瘤临床试验及适宜技术推广项目。作为第一作者及通信作者在国内核心期刊及SCI收录期刊Head and Neck、Thyroid、Cell Discovery上发表论文60余篇。担任多个国内核心期刊及SCI收录期刊的编委及审稿专家。担任国家癌症中心国家肿瘤质控中心甲状腺癌质控专家委员会委员、中国抗癌协会甲状腺肿瘤专业委员会副主任委员、中国医药教育协会头颈肿瘤专业委员会副主任委员、中国医疗保健国际交流促进会普通外科学分会副主任委员、中国抗癌协会头颈肿瘤专业委员会常委、上海市抗癌协会头颈肿瘤专业委员会候任主任委员。曾获多项全国性竞赛奖项。 " ]
收稿:2023-03-20,
修回:2023-05-08,
纸质出版:2023-05-30
移动端阅览
渠宁, 王钰婷, 马奔, 等. 2022年度甲状腺癌研究及诊疗新进展[J]. 中国癌症杂志, 2023,33(5):423-430.
Ning QU, Yuting WANG, Ben MA, et al. Advances in basic research, clinical diagnosis and treatment of thyroid cancer in 2022[J]. China Oncology, 2023, 33(5): 423-430.
渠宁, 王钰婷, 马奔, 等. 2022年度甲状腺癌研究及诊疗新进展[J]. 中国癌症杂志, 2023,33(5):423-430. DOI: 10.19401/j.cnki.1007-3639.2023.05.001.
Ning QU, Yuting WANG, Ben MA, et al. Advances in basic research, clinical diagnosis and treatment of thyroid cancer in 2022[J]. China Oncology, 2023, 33(5): 423-430. DOI: 10.19401/j.cnki.1007-3639.2023.05.001.
甲状腺癌是近年来发病率显著升高的内分泌系统恶性肿瘤,治疗以外科治疗为主,术后根据情况辅以内分泌治疗、放射性核素治疗,某些情况下需辅以放疗、靶向治疗。然而甲状腺癌的死亡率亦有升高趋势,晚期或低分化/去分化患者的预后差且生存时间短。基础和临床研究的推进,使得甲状腺癌的个体化治疗取得了新进展。现对2022年度甲状腺癌领域的研究进展进行综述。
Thyroid cancer is a common malignancy of the endocrine system with a significantly increased incidence in recent years. Surgical treatment is the primary treatment
followed by endocrine therapy and radionuclide therapy according to the clinical evaluations
and in some cases
radiotherapy and targeted therapy are needed. However
the mortality of thyroid cancer also tends to increase
especially in advanced or low/dedifferentiated patients with poor prognosis and short survival time. With the advancement of basic and clinical research
new progress has been made in individualized treatment of thyroid cancer. This article reviewed the research progress of thyroid cancer in 2022.
ZHENG R , ZHANG S , ZENG H , et al . Cancer incidence and mortality in China, 2016 [J ] . J Natl Cancer Center , 2022 , 2 ( 1 ): 1 - 9 DOI: 10.1016/j.jncc.2022.02.002 http://doi.org/10.1016/j.jncc.2022.02.002 https://linkinghub.elsevier.com/retrieve/pii/S2667005422000047 https://linkinghub.elsevier.com/retrieve/pii/S2667005422000047
ZHOU M G , WANG H D , ZENG X Y , et al . Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 [J ] . Lancet , 2019 , 394 ( 10204 ): 1145 - 1158 . DOI: S0140-6736(19)30427-1 http://doi.org/S0140-6736(19)30427-1
张新洲 , 刘劲松 , 许娴 , 等 . 2005—2016年中国甲状腺癌发病和死亡趋势分析 [J ] . 中华肿瘤防治杂志 , 2022 , 29 ( 24 ): 1725 - 1733 .
ZHANG X Z , LIU J S , XU X , et al . Trends of thyroid cancer incidence and mortality in China from 2005 to 2016 [J ] . Chin J Cancer Prev Treat , 2022 , 29 ( 24 ): 1725 - 1733 .
CHEN W Q , ZHENG R S , ZUO T T , et al . National cancer incidence and mortality in China, 2012 [J ] . Chin J Cancer Res , 2016 , 28 ( 1 ): 1 - 11 .
HONGMEI , ZENG , PHD , et al . Changing cancer survival in China during 2003-15: a pooled analysis of 17 population-based cancer registries [J ] . Lancet Glob Health , 2018 , 6 ( 5 ): e555-e567.
VACCARELLA S , LORTET-TIEULENT J , COLOMBET M , et al . Global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study [J ] . Lancet Diabetes Endocrinol , 2021 , 9 ( 3 ): 144 - 152 . DOI: 10.1016/S2213-8587(20)30401-0 http://doi.org/10.1016/S2213-8587(20)30401-0 https://linkinghub.elsevier.com/retrieve/pii/S2213858720304010 https://linkinghub.elsevier.com/retrieve/pii/S2213858720304010
黄志刚 , 陈晓红 . 分化型甲状腺癌个体化分层治疗的策略和意义 [J ] . 中华耳鼻咽喉头颈外科杂志 , 2017 , 52 ( 6 ): 405 - 409
HUANG Z G , CHEN X H . The strategy and significance of individualized stratified therapy for differentiated thyroid carcinoma [J ] . Chin J Otorhinolaryngol Head Neck Surg , 2017 , 52 ( 6 ): 405 - 409 .
ROMEI C , CIAMPI R , ELISEI R . A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma [J ] . Nat Rev Endocrinol , 2016 , 12 ( 4 ): 192 - 202 . DOI: 10.1038/nrendo.2016.11 http://doi.org/10.1038/nrendo.2016.11
贺青卿 , 于芳 , 范子义 , 等 . 单中心2 038例甲状腺癌20年随访及危险因素分析 [J ] . 中华内分泌外科杂志 , 2022 , 16 ( 1 ): 18 - 22 .
HE Q Q , YU F , FAN Z Y , et al . Risk factor analysis of 20-year follow-up of 2 038 cases of thyroid cancer: a single center study [J ] . Chin J Endocr Surg , 2022 , 16 ( 1 ): 18 - 22 .
LI X C , ZHANG S , ZHANG Q , et al . Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study [J ] . Lancet Oncol , 2019 , 20 ( 2 ): 193 - 201 . DOI: S1470-2045(18)30762-9 http://doi.org/S1470-2045(18)30762-9
FRANCO A T , RICARTE-FILHO J C , ISAZA A , et al . Fusion oncogenes are associated with increased metastatic capacity and persistent disease in pediatric thyroid cancers [J ] . J Clin Oncol , 2022 , 40 ( 10 ): 1081 - 1090 . DOI: 10.1200/JCO.21.01861 http://doi.org/10.1200/JCO.21.01861
DOOLITTLE W K L , ZHAO L , CHENG S Y . Blocking CDK7-mediated NOTCH1-cMYC signaling attenuates cancer stem cell activity in anaplastic thyroid cancer [J ] . Thyroid , 2022 , 32 ( 8 ): 937 - 948 . DOI: 10.1089/thy.2022.0087 http://doi.org/10.1089/thy.2022.0087
ZHANG P T , GUAN H X , YUAN S K , et al . Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF -mutant papillary thyroid cancer to MAPK inhibitors [J ] . Nat Commun , 2022 , 13 ( 1 ): 1588 . DOI: 10.1038/s41467-022-29000-5 http://doi.org/10.1038/s41467-022-29000-5
孙海燕 , 弓磊 , 于振涛 , 等 . 髓源性抑制细胞联合免疫检查点抑制剂抗肿瘤治疗的研究进展 [J ] . 肿瘤防治研究 , 2020 , 47 ( 9 ) 716 - 721
SUN H Y , GONG L , YU Z T , et al . Advances in anti-tumor therapy of myeloid-derived suppressor cells combined with immunological checkpoint inhibitors [J ] . Cancer Res Prev Treat , 2020 , 47 ( 9 ) 716 - 721
RABOLD K , ZOODSMA M , GRONDMAN I , et al . Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma [J ] . Nat Commun , 2022 , 13 ( 1 ): 6149 . DOI: 10.1038/s41467-022-33907-4 http://doi.org/10.1038/s41467-022-33907-4
YIP L , SOSA J A . Molecular-directed treatment of differentiated thyroid cancer: advances in diagnosis and treatment [J ] . JAMA Surg , 2016 , 151 ( 7 ): 663 - 670 . DOI: 10.1001/jamasurg.2016.0825 http://doi.org/10.1001/jamasurg.2016.0825
PENG S , LIU Y H , LV W M , et al . Deep learning-based artificial intelligence model to assist thyroid nodule diagnosis and management: a multicentre diagnostic study [J ] . Lancet Digit Health , 2021 , 3 ( 4 ): e250-e259.
MONTERO-CONDE C , LEANDRO-GARCÍA L J , et al .MARTÍNEZ-MONTES Á M, Comprehensive molecular analysis of immortalization hallmarks in thyroid cancer reveals new prognostic markers [J ] . Clin Transl Med , 2022 , 12 ( 8 ): e1001.
SUN Y T , SELVARAJAN S , ZANG Z L , et al . Artificial intelligence defines protein-based classification of thyroid nodules [J ] . Cell Discov , 2022 , 8 ( 1 ): 85 . DOI: 10.1038/s41421-022-00442-x http://doi.org/10.1038/s41421-022-00442-x
SHI X , SUN Y , SHEN C , et al . Integrated proteogenomic characterization of medullary thyroid carcinoma [J ] . Cell Discov , 2022 , 8 ( 1 ): 120 . DOI: 10.1038/s41421-022-00479-y http://doi.org/10.1038/s41421-022-00479-y
National Cancer Center , Thyroid Cancer Expert Committee of National Cancer Quality Control Center . Quality control index for standardized diagnosis and treatment of thyroid cancer in China (2022 edition) [J ] . Chin J Oncol , 2022 , 44 ( 9 ): 902 - 907 .
FILETTI S , DURANTE C , HARTL D , et al . Thyroid cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up [J ] . Ann Oncol , 2019 , 30 ( 12 ): 1856 - 1883 . DOI: S0923-7534(20)32555-2 http://doi.org/S0923-7534(20)32555-2
ZHANG Z Y , SUN B T , OUYANG H , et al . Endoscopic lateral neck dissection: a new frontier in endoscopic thyroid surgery [J ] . Front Endocrinol (Lausanne) , 2021 , 12 : 796984 . DOI: 10.3389/fendo.2021.796984 http://doi.org/10.3389/fendo.2021.796984 https://www.frontiersin.org/articles/10.3389/fendo.2021.796984/full https://www.frontiersin.org/articles/10.3389/fendo.2021.796984/full
中国抗癌协会 . 中国肿瘤整合诊治指南(CACA)甲状腺癌2022版 [M ] . 天津科学技术出版社 , 2022 .
China Anti-Cancer Association . China Cancer Integrated Diagnosis and Treatment Guidelines (CACA) for thyroid cancer 2022 edition [M ] . Tianjin Science and Technology Press , 2022 .
中华人民共和国国家卫生健康委员会医政医管局 . 甲状腺癌诊疗指南(2022年版) [J ] . 中国实用外科杂志 , 2022 , 42 ( 12 ): 1343 - 1357 , 1363.
National Health Commission of the People’s Republic of China Medical Administration and Hospital Administration . Guidelines for the diagnosis and treatment of thyroid carcinoma [J ] . Chin J Pract Surg , 2022 , 42 ( 12 ): 1343 - 1357 , 1363.
纪玲霞 , 周爱琴 , 周雪梅 . 调强放疗治疗甲状腺癌术后残留和复发的临床效果研究 [J ] . 实用癌症杂志 , 2022 , 37 ( 5 ): 858 - 860
JI L X , ZHOU A Q , ZHOU X M . Clinical study on the effect of intensive modulation radiotherapy in the treatment of residue and recurrence after thyroid cancer [J ] . Pract J Cancer , 2022 , 37 ( 5 ): 858 - 860
KWON J , KIM B H , JUNG H W , et al . The prognostic impacts of postoperative radiotherapy in the patients with resected anaplastic thyroid carcinoma: a systematic review and meta-analysis [J ] . Eur J Cancer , 2016 , 59 : 34 - 45 . DOI: S0959-8049(16)00130-1 http://doi.org/S0959-8049(16)00130-1
ORLANDI F , CARACI P , BERRUTI A , et al . Chemotherapy with dacarbazine and 5-fluorouracil in advanced medullary thyroid cancer [J ] . Ann Oncol , 1994 , 5 ( 8 ): 763 - 765 .
SCHLUMBERGER M , LEBOULLEUX S . Current practice in patients with differentiated thyroid cancer [J ] . Nat Rev Endocrinol , 2021 , 17 ( 3 ): 176 - 188 . DOI: 10.1038/s41574-020-00448-z http://doi.org/10.1038/s41574-020-00448-z
HO A L , DEDECJUS M , WIRTH L J , et al . Selumetinib plus adjuvant radioactive iodine in patients with high-risk differentiated thyroid cancer: a phase Ⅲ, randomized, placebo-controlled trial (ASTRA) [J ] . J Clin Oncol , 2022 , 40 ( 17 ): 1870 - 1878 . DOI: 10.1200/JCO.21.00714 http://doi.org/10.1200/JCO.21.00714 https://ascopubs.org/doi/10.1200/JCO.21.00714 https://ascopubs.org/doi/10.1200/JCO.21.00714
CAO J J , ZHU X L , SUN Y R , et al . The genetic duet of BRAF V600E and TERT promoter mutations predicts the poor curative effect of radioiodine therapy in papillary thyroid cancer [J ] . Eur J Nucl Med Mol Imaging , 2022 , 49 ( 10 ): 3470 - 3481 . DOI: 10.1007/s00259-022-05820-x http://doi.org/10.1007/s00259-022-05820-x
NABHAN F , DEDHIA P H , RINGEL M D . Thyroid cancer, recent advances in diagnosis and therapy [J ] . Int J Cancer , 2021 , 149 ( 5 ): 984 - 992 . DOI: 10.1002/ijc.33690 http://doi.org/10.1002/ijc.33690
National Comprehensive Cancer Network . NCCN clinical practice guidelines in thyroid cancer (2022 version Ⅰ) [DB/OL ] . [ 2023-04-28 ] . http://www.nccn.org. http://www.nccn.org http://www.nccn.org
SUBBIAH V , KREITMAN R J , WAINBERG Z A , et al . Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase Ⅱ ROAR basket study [J ] . Ann Oncol , 2022 , 33 ( 4 ): 406 - 415 . DOI: 10.1016/j.annonc.2021.12.014 http://doi.org/10.1016/j.annonc.2021.12.014 https://linkinghub.elsevier.com/retrieve/pii/S0923753422000059 https://linkinghub.elsevier.com/retrieve/pii/S0923753422000059
HUANG N S , WEI W J , XIANG J , et al . The efficacy and safety of anlotinib in neoadjuvant treatment of locally advanced thyroid cancer: a single-arm phase Ⅱ clinical trial [J ] . Thyroid , 2021 , 31 ( 12 ): 1808 - 1813 . DOI: 10.1089/thy.2021.0307 http://doi.org/10.1089/thy.2021.0307 https://www.liebertpub.com/doi/10.1089/thy.2021.0307 https://www.liebertpub.com/doi/10.1089/thy.2021.0307
SARONNI D , GAUDENZI G , DICITORE A , et al . Preclinical evaluation of novel tyrosine-kinase inhibitors in medullary thyroid cancer [J ] . Cancers (Basel) , 2022 , 14 ( 18 ): 4442 . DOI: 10.3390/cancers14184442 http://doi.org/10.3390/cancers14184442 https://www.mdpi.com/2072-6694/14/18/4442 https://www.mdpi.com/2072-6694/14/18/4442
中国临床肿瘤学会指南工作委员会 . 中国临床肿瘤学会(CSCO)分化型甲状腺癌诊疗指南2021 [J ] . 肿瘤预防与治疗 , 2021 , 34 ( 12 ): 1164 - 1201 .
Working Committee of the Guidelines of the Chinese Society of Clinical Oncology . Guidelines of Chinese Society of Clinical Oncology (CSCO) differentiated thyroid cancer [J ] . J Cancer Control Treat , 2021 , 34 ( 12 ): 1164 - 1201 .
SUBBIAH V , HU M I , WIRTH L J , et al . Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW): a multi-cohort, open-label, registrational, phase 1/2 study [J ] . Lancet Diabetes Endocrinol , 2021 , 9 ( 8 ): 491 - 501 . DOI: 10.1016/S2213-8587(21)00120-0 http://doi.org/10.1016/S2213-8587(21)00120-0 https://linkinghub.elsevier.com/retrieve/pii/S2213858721001200 https://linkinghub.elsevier.com/retrieve/pii/S2213858721001200
RAMAN R , VILLEFRANC J A , ULLMANN T M , et al . Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer [J ] . J Exp Med , 2022 , 219 ( 6 ): e20210390.
LEE Y A , LEE H , IM S W , et al . NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake [J ] . J Clin Invest , 2021 , 131 ( 18 ): e144847.
WAGUESPACK S G , DRILON A , LIN J J , et al . Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma [J ] . Eur J Endocrinol , 2022 , 186 ( 6 ): 631 - 643 . DOI: 10.1530/EJE-21-1259 http://doi.org/10.1530/EJE-21-1259 https://academic.oup.com/ejendo/article/186/6/631/6853698 https://academic.oup.com/ejendo/article/186/6/631/6853698
0
浏览量
7456
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621