荧光成像技术在口腔癌诊疗中的应用及进展

许弘弢; 黄小娟; 郑重阳; 张志愿

doi:10.19401/j.cnki.1007-3639.2023.09.008

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荧光成像技术在口腔癌诊疗中的应用及进展

综述 | 更新时间：2025-12-31

- 荧光成像技术在口腔癌诊疗中的应用及进展
- Development and progress of fluorescence imaging technology in diagnosis and treatment of oral cancer
- 中国癌症杂志 2023年33卷第9期页码：874-878
- 作者机构：
  
  上海交通大学医学院附属第九人民医院口腔颌面头颈肿瘤科，上海交通大学口腔医学院，国家口腔医学中心，国家口腔疾病临床医学研究中心，上海市口腔医学重点实验室，上海市口腔医学研究所，中国医学科学院口腔颌面再生医学创新单元，上海 200011
- 作者简介：
  
  [ "许弘弢（ORCID: 0000-0003-3660-284X），硕士。" ]
  张志愿（ORCID: 0000-0001-8569-7326），博士，教授。
- 基金信息：
  
  国家自然科学基金(82002853);上海市口腔疾病临床医学研究中心(19MC1910600);上海市临床重点专科(shslczdzk 01601);中国医学科学院医学与健康科技创新工程项目(2019-I2M-5-037);浙江省医药卫生科技计划项目(2020KY939)
- DOI：10.19401/j.cnki.1007-3639.2023.09.008
  中图分类号： R739.85
- 收稿：2023-02-01，
  
  修回：2023-05-04，
  
  纸质出版：2023-09-30
- 稿件说明：
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许弘弢, 黄小娟, 郑重阳, 等. 荧光成像技术在口腔癌诊疗中的应用及进展[J]. 中国癌症杂志, 2023,33(9):874-878.

Hongtao XU, Xiaojuan HUANG, Chongyang ZHENG, et al. Development and progress of fluorescence imaging technology in diagnosis and treatment of oral cancer[J]. China Oncology, 2023, 33(9): 874-878.
许弘弢, 黄小娟, 郑重阳, 等. 荧光成像技术在口腔癌诊疗中的应用及进展[J]. 中国癌症杂志, 2023,33(9):874-878. DOI： 10.19401/j.cnki.1007-3639.2023.09.008.

Hongtao XU, Xiaojuan HUANG, Chongyang ZHENG, et al. Development and progress of fluorescence imaging technology in diagnosis and treatment of oral cancer[J]. China Oncology, 2023, 33(9): 874-878. DOI： 10.19401/j.cnki.1007-3639.2023.09.008.

摘要

口腔癌治疗目前面临的主要临床问题是术后复发和转移。如何提高手术切除效率、改善患者预后是实现口腔癌根治的关键。荧光成像技术作为辅助性手段应用于口腔癌的诊断和治疗，能够以非侵入、无辐射的方式提供实时、超高分辨率的影像学资料，达到术前肿瘤识别诊断、术中肿瘤边界确定及术后癌床检查的效果，有助于降低复发率、提高患者生存率和生存质量。本文就应用于口腔癌临床和基础研究的代表性荧光探针及其特点、局限性和应用前景予以综述。

Abstract

The main clinical problems in treatment of oral cancer are tumor recurrence and metastasis after surgery. To improve the efficiency of resection and the prognosis of patients is a key to curing oral cancer. Fluorescence imaging

as an adjuvant in the diagnosis and treatment of oral cancer with no invasion and radiation

can provide real-time and ultrahigh-resolution graphics for preoperative tumor diagnosis

intraoperative tumor margin determination and postoperative tumor bed checking

which can help reduce the recurrent rate

enhance the survival rate and improve the life quality of patients. This article reviewed several typical fluorescent probes and discussed their characteristics

limitations and application prospects in clinic or research for oral cancer.

关键词

Keywords

references

ZHENG C Y , ZHANG X Y , WANG L T , et al . Versatile cobalt-glycerate nanoplatform for MR-guided neoadjuvant photo-therapy of oral squamous cell carcinoma [J ] . Chem Eng J , 2022 , 437 : 135476 . DOI: 10.1016/j.cej.2022.135476 http://doi.org/10.1016/j.cej.2022.135476 https://linkinghub.elsevier.com/retrieve/pii/S1385894722009792 https://linkinghub.elsevier.com/retrieve/pii/S1385894722009792

KAIN J J , BIRKELAND A C , UDAYAKUMAR N , et al . Surgical margins in oral cavity squamous cell carcinoma: current practices and future directions [J ] . Laryngoscope , 2020 , 130 ( 1 ): 128 - 138 . DOI: 10.1002/lary.v130.1 http://doi.org/10.1002/lary.v130.1 https://onlinelibrary.wiley.com/toc/15314995/130/1 https://onlinelibrary.wiley.com/toc/15314995/130/1

CHIOSEA S I . Intraoperative margin assessment in early oral squamous cell carcinoma [J ] . Surg Pathol Clin , 2017 , 10 ( 1 ): 1 - 14 . DOI: S1875-9181(16)30089-7 http://doi.org/S1875-9181(16)30089-7

CWALINSKI T , POLOM W , MARANO L , et al . Methylene blue-current knowledge, fluorescent properties, and its future use [J ] . J Clin Med , 2020 , 9 ( 11 ): 3538 . DOI: 10.3390/jcm9113538 http://doi.org/10.3390/jcm9113538 https://www.mdpi.com/2077-0383/9/11/3538 https://www.mdpi.com/2077-0383/9/11/3538

WAQAS M , SHAMIM M S . Sodium fluorescein guided resection of malignant glioma [J ] . J Pak Med Assoc , 2018 , 68 ( 6 ): 968 - 970 .

HARA T , INAMI M , HARA T . Efficacy and safety of fluorescein angiography with orally administered sodium fluorescein [J ] . Am J Ophthalmol , 1998 , 126 ( 4 ): 560 - 564 . DOI: 10.1016/s0002-9394(98)00112-3 http://doi.org/10.1016/s0002-9394(98)00112-3

QAISER D , SOOD A , MISHRA D , et al . Novel use of fluorescein dye in detection of oral dysplasia and oral cancer [J ] . Photodiagnosis Photodyn Ther , 2020 , 31 : 101824 . DOI: 10.1016/j.pdpdt.2020.101824 http://doi.org/10.1016/j.pdpdt.2020.101824 https://linkinghub.elsevier.com/retrieve/pii/S1572100020301782 https://linkinghub.elsevier.com/retrieve/pii/S1572100020301782

DU L Z , MA S W , WEN X , et al . Oral squamous cell carcinoma cells are resistant to doxorubicin through upregulation of miR-221 [J ] . Mol Med Rep , 2017 , 16 ( 3 ): 2659 - 2667 . DOI: 10.3892/mmr.2017.6915 http://doi.org/10.3892/mmr.2017.6915 https://www.spandidos-publications.com/10.3892/mmr.2017.6915 https://www.spandidos-publications.com/10.3892/mmr.2017.6915

LE M N , WUERTZ B R , BIEL M A , et al . Effects of methylene blue photodynamic therapy on oral carcinoma and leukoplakia cells [J ] . Laryngoscope Investig Otolaryngol , 2022 , 7 ( 4 ): 982 - 987 . DOI: 10.1002/lio2.772 http://doi.org/10.1002/lio2.772

VISHNOI J R , KUMAR V , GUPTA S , et al . Outcome of sentinel lymph node biopsy in early-stage squamous cell carcinoma of the oral cavity with methylene blue dye alone: a prospective validation study [J ] . Br J Oral Maxillofac Surg , 2019 , 57 ( 8 ): 755 - 759 . DOI: S0266-4356(19)30247-5 http://doi.org/S0266-4356(19)30247-5

ZHENG W , OLIVO M , SOO K C . The use of digitized endoscopic imaging of 5-ALA-induced PPⅨ fluorescence to detect and diagnose oral premalignant and malignant lesions in vivo [J ] . Int J Cancer , 2004 , 110 ( 2 ): 295 - 300 . DOI: 10.1002/(ISSN)1097-0215 http://doi.org/10.1002/(ISSN)1097-0215 http://doi.wiley.com/10.1002/%28ISSN%291097-0215 http://doi.wiley.com/10.1002/%28ISSN%291097-0215

REINHART M B , HUNTINGTON C R , BLAIR L J , et al . Indocyanine green: historical context, current applications, and future considerations [J ] . Surg Innov , 2016 , 23 ( 2 ): 166 - 175 . DOI: 10.1177/1553350615604053 http://doi.org/10.1177/1553350615604053

SHINDY H A . Fundamentals in the chemistry of cyanine dyes: a review [J ] . Dyes Pigments , 2017 , 145 : 505 - 513 . DOI: 10.1016/j.dyepig.2017.06.029 http://doi.org/10.1016/j.dyepig.2017.06.029 https://linkinghub.elsevier.com/retrieve/pii/S0143720817305569 https://linkinghub.elsevier.com/retrieve/pii/S0143720817305569

PAN J R , DENG H , HU S Q , et al . Real-time surveillance of surgical margins via ICG-based near-infrared fluorescence imaging in patients with OSCC [J ] . World J Surg Oncol , 2020 , 18 ( 1 ): 96 . DOI: 10.1186/s12957-020-01874-z http://doi.org/10.1186/s12957-020-01874-z

LEE Y J , KRISHNAN G , NISHIO N , et al . Intraoperative fluorescence-guided surgery in head and neck squamous cell carcinoma [J ] . Laryngoscope , 2021 , 131 ( 3 ): 529 - 534 . DOI: 10.1002/lary.v131.3 http://doi.org/10.1002/lary.v131.3 https://onlinelibrary.wiley.com/toc/15314995/131/3 https://onlinelibrary.wiley.com/toc/15314995/131/3

VAN SCHAIK J E , HALMOS G B , WITJES M J H , et al . An overview of the current clinical status of optical imaging in head and neck cancer with a focus on Narrow Band imaging and fluorescence optical imaging [J ] . Oral Oncol , 2021 , 121 : 105504 . DOI: 10.1016/j.oraloncology.2021.105504 http://doi.org/10.1016/j.oraloncology.2021.105504 https://linkinghub.elsevier.com/retrieve/pii/S1368837521006102 https://linkinghub.elsevier.com/retrieve/pii/S1368837521006102

BHANDARI C , FAKHRY J , EROY M , et al . Towards photodynamic image-guided surgery of head and neck tumors: photodynamic priming improves delivery and diagnostic accuracy of cetuximab-IRDye800CW [J ] . Front Oncol , 2022 , 12 : 853660 . DOI: 10.3389/fonc.2022.853660 http://doi.org/10.3389/fonc.2022.853660 https://www.frontiersin.org/articles/10.3389/fonc.2022.853660/full https://www.frontiersin.org/articles/10.3389/fonc.2022.853660/full

ROSENTHAL E L , WARRAM J M , DE BOER E , et al . Safety and tumor specificity of cetuximab-IRDye800 for surgical navigation in head and neck cancer [J ] . Clin Cancer Res , 2015 , 21 ( 16 ): 3658 - 3666 . DOI: 10.1158/1078-0432.CCR-14-3284 http://doi.org/10.1158/1078-0432.CCR-14-3284

ZHU S J , TIAN R , ANTARIS A L , et al . Near-infrared-Ⅱ molecular dyes for cancer imaging and surgery [J ] . Adv Mater , 2019 , 31 ( 24 ): e1900321 .

ZHOU J , LIU Z , LI F Y . Upconversion nanophosphors for small-animal imaging [J ] . Chem Soc Rev , 2012 , 41 ( 3 ): 1323 - 1349 . DOI: 10.1039/c1cs15187h http://doi.org/10.1039/c1cs15187h

LIN B , WU J , WANG Y X , et al . Peptide functionalized upconversion/NIR-Ⅱ luminescent nanoparticles for targeted imaging and therapy of oral squamous cell carcinoma [J ] . Biomater Sci , 2021 , 9 ( 3 ): 1000 - 1007 . DOI: 10.1039/D0BM01737J http://doi.org/10.1039/D0BM01737J http://xlink.rsc.org/?DOI=D0BM01737J http://xlink.rsc.org/?DOI=D0BM01737J

ZHU C N , CHEN G , TIAN Z Q , et al . Near-infrared fluorescent Ag2Se-cetuximab nanoprobes for targeted imaging and therapy of cancer [J ] . Small , 2017 , 13 ( 3 ).

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