P53与肿瘤代谢的最新研究进展

翟海晖; 刘元祺; 张从政; 官立萍; 韩涛

doi:10.19401/j.cnki.1007-3639.2023.11.009

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P53与肿瘤代谢的最新研究进展

综述 | 更新时间：2025-12-31

- P53与肿瘤代谢的最新研究进展
- The latest research progress on P53 and tumor metabolism
- 中国癌症杂志 2023年33卷第11期页码：1032-1040
- 作者机构：
  
  1. 新乡医学院健康中原研究院，河南新乡 453003
  2. 新乡医学院基础医学院，河南新乡 453003
- 作者简介：
  
  [ "翟海晖（ORCID: 0009-0002-9211-7224），学士。" ]
  韩涛（ORCID: 0000-0002-5943-8520），博士，教授。
- 基金信息：
  
  河南省高校省级大学生创新创业计划训练项目(202210472024)
- DOI：10.19401/j.cnki.1007-3639.2023.11.009
  中图分类号： R730.2
- 收稿：2023-08-09，
  
  修回：2023-10-17，
  
  纸质出版：2023-11-30
- 稿件说明：
移动端阅览
翟海晖, 刘元祺, 张从政, 等. P53与肿瘤代谢的最新研究进展[J]. 中国癌症杂志, 2023,33(11):1032-1040.

Haihui ZHAI, Yuanqi LIU, Congzheng ZHANG, et al. The latest research progress on P53 and tumor metabolism[J]. China Oncology, 2023, 33(11): 1032-1040.
翟海晖, 刘元祺, 张从政, 等. P53与肿瘤代谢的最新研究进展[J]. 中国癌症杂志, 2023,33(11):1032-1040. DOI： 10.19401/j.cnki.1007-3639.2023.11.009.

Haihui ZHAI, Yuanqi LIU, Congzheng ZHANG, et al. The latest research progress on P53 and tumor metabolism[J]. China Oncology, 2023, 33(11): 1032-1040. DOI： 10.19401/j.cnki.1007-3639.2023.11.009.

摘要

由

53编码的P53蛋白是防止细胞癌变所需的关键因子，有广泛而强大的功能。P53在诱导细胞周期停滞、DNA损伤修复、细胞凋亡和衰老等过程中发挥重要作用，且这些功能的丧失不会使P53失去抑癌活性。新陈代谢是生命的基础，代谢异常导致多种疾病如肿瘤的发生，是癌症进展的主要驱动力之一。最近研究发现P53在调节全身代谢中起关键作用。P53介导的细胞代谢调节是控制肿瘤发生、发展的基本机制，有助于抑制肿瘤活性。本文就P53与葡萄糖、脂肪酸、氨基酸和核苷酸代谢的关系进行综述，并梳理肿瘤发展中P53在这些代谢调控中的复杂机制和最新研究进展。

Abstract

P53 is a key factor encoded by the

and it prevents cells from becoming cancerous and has a wide range of powerful functions. p53 is found to play an important role in inducing DNA repair

apoptosis

cell cycle arrest and senescence

and the loss of these functions does not abrogate P53’s tumor suppressive activity. Metabolism is the basis of life

and metabolic abnormalities can lead to a variety of diseases

including tumors

and is one of the main drivers of cancer progression. It has recently been discovered that P53 plays a key role in regulating metabolism. P53-mediated regulation of cell metabolism is a fundamental mechanism controlling cancer occurrence and development and contributes to its tumor suppressive activity. Here

this article reviewed the relationship between P53 and glucose

fatty acid

amino acid and nucleotide metabolism

and discussed the complex mechanism and the latest research progress of P53 in the metabolic regulation in tumor development.

关键词

Keywords

references

LACROIX M , RISCAL R , ARENA G , et al . Metabolic functions of the tumor suppressor p 53: implications in normal physiology, metabolic disorders, and cancer [J ] . Mol Metab , 2020 , 33 : 2 - 22 . DOI: 10.1016/j.molmet.2019.10.002 http://doi.org/10.1016/j.molmet.2019.10.002 https://linkinghub.elsevier.com/retrieve/pii/S2212877819309214 https://linkinghub.elsevier.com/retrieve/pii/S2212877819309214

MAO Y , JIANG P . The crisscross between p 53 and metabolism in cancer [J ] . Acta Biochim Biophys Sin (Shanghai) , 2023 , 55 ( 6 ): 914 - 922 . DOI: 10.3724/abbs.2023109 http://doi.org/10.3724/abbs.2023109 https://engine.scichina.com/doi/10.3724/abbs.2023109 https://engine.scichina.com/doi/10.3724/abbs.2023109

FU X , WU S , LI B , et al . Functions of p 53 in pluripotent stem cells [J ] . Protein Cell , 2020 , 11 ( 1 ): 71 - 78 . DOI: 10.1007/s13238-019-00665-x http://doi.org/10.1007/s13238-019-00665-x

ZAFAR A , KHAN M J , NAEEM A . MDM2- an indispensable player in tumorigenesis [J ] . Mol Biol Rep , 2023 , 50 ( 8 ): 6871 - 6883 . DOI: 10.1007/s11033-023-08512-3 http://doi.org/10.1007/s11033-023-08512-3

HOU Y C , ZHANG X T , YAO H , et al . METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p 53-wild-type cells [J ] . EMBO Rep , 2023 , 24 ( 4 ): e56325 . DOI: 10.15252/embr.202256325 http://doi.org/10.15252/embr.202256325 https://www.embopress.org/doi/10.15252/embr.202256325 https://www.embopress.org/doi/10.15252/embr.202256325

MARCUCCI F , RUMIO C . On the role of glycolysis in early tumorigenesis-permissive and executioner effects [J ] . Cells , 2023 , 12 ( 8 ): 1124 . DOI: 10.3390/cells12081124 http://doi.org/10.3390/cells12081124 https://www.mdpi.com/2073-4409/12/8/1124 https://www.mdpi.com/2073-4409/12/8/1124

SHEN J Z , WANG Q R , MAO Y N , et al . Targeting the p53 signaling pathway in cancers: molecular mechanisms and clinical studies [J ] . MedComm (2020) , 2023 , 4 ( 3 ): e288 .

WHITT A G , NEELY A M , SARKAR O S , et al . Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis [J ] . Sci Rep , 2023 , 13 ( 1 ): 9929 . DOI: 10.1038/s41598-023-37146-5 http://doi.org/10.1038/s41598-023-37146-5

KLEINEHR J , SCHÖFBÄNKER M , DANIEL K , et al . Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA [J ] . PLoS Pathog , 2023 , 19 ( 7 ): e1010986 . DOI: 10.1371/journal.ppat.1010986 http://doi.org/10.1371/journal.ppat.1010986 https://dx.plos.org/10.1371/journal.ppat.1010986 https://dx.plos.org/10.1371/journal.ppat.1010986

MUKHERJEE A G , GOPALAKRISHNAN A V . The mechanistic insights of the antioxidant Keap1-Nrf2 pathway in oncogenesis: a deadly scenario [J ] . Med Oncol , 2023 , 40 ( 9 ): 248 . DOI: 10.1007/s12032-023-02124-4 http://doi.org/10.1007/s12032-023-02124-4

EWUNKEM A J , DEVE M , HARRISON S H , et al . Diepoxybutane induces the p 53-dependent transactivation of the CCL 4 gene that mediates apoptosis in exposed human lymphoblasts [J ] . J Biochem Mol Toxicol , 2023 , 37 ( 5 ): e23316 . DOI: 10.1002/jbt.v37.5 http://doi.org/10.1002/jbt.v37.5 https://onlinelibrary.wiley.com/toc/10990461/37/5 https://onlinelibrary.wiley.com/toc/10990461/37/5

HUANG J J , DU J J , LIN W J , et al . Regulation of lactate production through p 53/β-enolase axis contributes to statin-associated muscle symptoms [J ] . EBioMedicine , 2019 , 45 : 251 - 260 . DOI: 10.1016/j.ebiom.2019.06.003 http://doi.org/10.1016/j.ebiom.2019.06.003 https://linkinghub.elsevier.com/retrieve/pii/S2352396419303780 https://linkinghub.elsevier.com/retrieve/pii/S2352396419303780

CHETTA P , SRIRAM R , ZADRA G . Lactate as key metabolite in prostate cancer progression: what are the clinical implications? [J ] . Cancers (Basel) , 2023 , 15 ( 13 ): 3473 . DOI: 10.3390/cancers15133473 http://doi.org/10.3390/cancers15133473 https://www.mdpi.com/2072-6694/15/13/3473 https://www.mdpi.com/2072-6694/15/13/3473

KAM C S , HO D W , MING V S , et al . PFKFB4 drives the oncogenicity in TP 53-mutated hepatocellular carcinoma in a phosphatase-dependent manner [J ] . Cell Mol Gastroenterol Hepatol , 2023 , 15 ( 6 ): 1325 - 1350 . DOI: 10.1016/j.jcmgh.2023.02.004 http://doi.org/10.1016/j.jcmgh.2023.02.004 https://linkinghub.elsevier.com/retrieve/pii/S2352345X23000231 https://linkinghub.elsevier.com/retrieve/pii/S2352345X23000231

KOUZU H , TATEKOSHI Y , CHANG H C , et al . ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice [J ] . J Clin Invest , 2022 , 132 ( 10 ): e154491 . DOI: 10.1172/JCI154491 http://doi.org/10.1172/JCI154491 https://www.jci.org/articles/view/154491 https://www.jci.org/articles/view/154491

ROBERSON P A , KINCHELOE G N , WELLES J E , et al . Glucose-induced activation of mTORC1 is associated with hexokinase 2 binding to sestrins in HEK293T cells [J ] . J Nutr , 2023 , 153 ( 4 ): 988 - 998 . DOI: 10.1016/j.tjnut.2022.11.021 http://doi.org/10.1016/j.tjnut.2022.11.021 https://linkinghub.elsevier.com/retrieve/pii/S0022316622132438 https://linkinghub.elsevier.com/retrieve/pii/S0022316622132438

CASTELLANOS G , VALBUENA D S , PÉREZ E , et al . Chromosomal instability as enabling feature and central hallmark of breast cancer [J ] . Breast Cancer (Dove Med Press) , 2023 , 15 : 189 - 211 .

WANG H L , GUO M , WEI H D , et al . Targeting p 53 pathways: mechanisms, structures, and advances in therapy [J ] . Signal Transduct Target Ther , 2023 , 8 ( 1 ): 92 .

ZHAN H , ZHANG Q , ZHANG C , et al . Targeted activation of HNF4α by AMPK inhibits apoptosis and ameliorates neurological injury caused by cardiac arrest in rats [J ] . Neurochem Res , 2023 , 48 ( 10 ): 3129 - 3145 . DOI: 10.1007/s11064-023-03957-1 http://doi.org/10.1007/s11064-023-03957-1

XIONG C , LING H , HAO Q , et al . Cuproptosis: P53-regulated metabolic cell death? [J ] . Cell Death Differ , 2023 , 30 ( 4 ): 876 - 884 . DOI: 10.1038/s41418-023-01125-0 http://doi.org/10.1038/s41418-023-01125-0

TANG M , XU H , HUANG H Y , et al . Metabolism-based molecular subtyping endows effective ketogenic therapy in p 53-mutant colon cancer [J ] . Adv Sci (Weinh) , 2022 , 9 ( 29 ): e2201992 .

LIU Y Q , GU W . The complexity of p53-mediated metabolic regulation in tumor suppression [J ] . Semin Cancer Biol , 2022 , 85 : 4 - 32 . DOI: 10.1016/j.semcancer.2021.03.010 http://doi.org/10.1016/j.semcancer.2021.03.010 https://linkinghub.elsevier.com/retrieve/pii/S1044579X21000602 https://linkinghub.elsevier.com/retrieve/pii/S1044579X21000602

HAN Y L , LIANG C , YU Y X , et al . Gluconeogenesis alteration and p53-SIRT6-Fox01 signaling adaptive regulation in sheep from different grazing periods [J ] . Comput Math Methods Med , 2022 , 2022 : 4614665 .

SANFORD J D , FRANKLIN D , GROIS G A , et al . Carnitine o-octanoyltransferase is a p 53 target that promotes oxidative metabolism and cell survival following nutrient starvation [J ] . J Biol Chem , 2023 , 299 ( 7 ): 104908 . DOI: 10.1016/j.jbc.2023.104908 http://doi.org/10.1016/j.jbc.2023.104908 https://linkinghub.elsevier.com/retrieve/pii/S0021925823019361 https://linkinghub.elsevier.com/retrieve/pii/S0021925823019361

ZHANG X Y , TAO G R , JIANG J , et al . PCK1 activates oncogenic autophagy via down-regulation serine phosphorylation of UBAP2L and antagonizes colorectal cancer growth [J ] . Cancer Cell Int , 2023 , 23 ( 1 ): 68 . DOI: 10.1186/s12935-023-02894-x http://doi.org/10.1186/s12935-023-02894-x

REINISCH I , KLYMIUK I , MICHENTHALER H , et al . p 53 regulates a miRNA-fructose transporter axis in brown adipose tissue under fasting [J ] . Front Genet , 2022 , 13 : 913030 . DOI: 10.3389/fgene.2022.913030 http://doi.org/10.3389/fgene.2022.913030 https://www.frontiersin.org/articles/10.3389/fgene.2022.913030/full https://www.frontiersin.org/articles/10.3389/fgene.2022.913030/full

SAFI A , SABERIYAN M , SANAEI M J , et al . The role of noncoding RNAs in metabolic reprogramming of cancer cells [J ] . Cell Mol Biol Lett , 2023 , 28 ( 1 ): 37 . DOI: 10.1186/s11658-023-00447-8 http://doi.org/10.1186/s11658-023-00447-8

LIU Y , WANG J D , JIANG M X . Copper-related genes predict prognosis and characteristics of breast cancer [J ] . Front Immunol , 2023 , 14 : 1145080 . DOI: 10.3389/fimmu.2023.1145080 http://doi.org/10.3389/fimmu.2023.1145080 https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145080/full https://www.frontiersin.org/articles/10.3389/fimmu.2023.1145080/full

MORRIS J P 4th , YASHINSKIE J J , KOCHE R , et al . Alpha-ketoglutarate links p 53 to cell fate during tumour suppression [J ] . Nature , 2019 , 573 ( 7775 ): 595 - 599 . DOI: 10.1038/s41586-019-1577-5 http://doi.org/10.1038/s41586-019-1577-5

DA FONSECA JUNIOR A M , ISPADA J , DOS SANTOS E C , et al . Adaptative response to changes in pyruvate metabolism on the epigenetic landscapes and transcriptomics of bovine embryos [J ] . Sci Rep , 2023 , 13 ( 1 ): 11504 . DOI: 10.1038/s41598-023-38686-6 http://doi.org/10.1038/s41598-023-38686-6

LI X , WU L M , ZOPP M , et al . p 53- TP 53-induced glycolysis regulator mediated glycolytic suppression attenuates DNA damage and genomic instability in fanconi anemia hematopoietic stem cells [J ] . Stem Cells , 2019 , 37 ( 7 ): 937 - 947 . DOI: 10.1002/stem.3015 http://doi.org/10.1002/stem.3015

WEI J , WANG S , ZHU H , et al . Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p 53 and NRF 1 activation [J ] . iScience , 2023 , 26 ( 7 ): 107220 . DOI: 10.1016/j.isci.2023.107220 http://doi.org/10.1016/j.isci.2023.107220 https://linkinghub.elsevier.com/retrieve/pii/S258900422301297X https://linkinghub.elsevier.com/retrieve/pii/S258900422301297X

JAHOOR ALAM M . Insights from the p 53 induced TIGAR protein 2 in the glycolytic pathway model [J ] . Bioinformation , 2022 , 18 ( 3 ): 310 - 317 . DOI: 10.6026/bioinformation http://doi.org/10.6026/bioinformation https://www.bioinformation.net/ https://www.bioinformation.net/

LIU Y Q , GU W . p 53 in ferroptosis regulation: the new weapon for the old guardian [J ] . Cell Death Differ , 2022 , 29 ( 5 ): 895 - 910 . DOI: 10.1038/s41418-022-00943-y http://doi.org/10.1038/s41418-022-00943-y

DOU X Z , GUO H , D’AMICO T , et al . CryoEM structure with ATP synthase enables late-stage diversification of Cruentaren A [J ] . Chemistry , 2023 , 29 ( 29 ): e202 300262.

ROHBECK E , NIERSMANN C , KÖHRER K , et al . Positive allosteric GABAA receptor modulation counteracts lipotoxicity-induced gene expression changes in hepatocytes in vitro [J ] . Front Physiol , 2023 , 14 : 1106075 . DOI: 10.3389/fphys.2023.1106075 http://doi.org/10.3389/fphys.2023.1106075 https://www.frontiersin.org/articles/10.3389/fphys.2023.1106075/full https://www.frontiersin.org/articles/10.3389/fphys.2023.1106075/full

HAO Q , CHEN J X , LU H , et al . The ARTS of p 53-dependent mitochondrial apoptosis [J ] . J Mol Cell Biol , 2023 , 14 ( 10 ): mjac074 . DOI: 10.1093/jmcb/mjac074 http://doi.org/10.1093/jmcb/mjac074 https://academic.oup.com/jmcb/article/doi/10.1093/jmcb/mjac074/6960679 https://academic.oup.com/jmcb/article/doi/10.1093/jmcb/mjac074/6960679

LI G , WU J , LI L , et al . p 53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage [J ] . Proc Natl Acad Sci USA , 2021 , 118 ( 28 ): e2019 822118.

RAINHO M A , SIQUEIRA P B , DE AMORIM Í S S , et al . Mitochondria in colorectal cancer stem cells-a target in drug resistance [J ] . Cancer Drug Resist , 2023 , 6 ( 2 ): 273 - 283 . DOI: 10.20517/cdr http://doi.org/10.20517/cdr https://cdrjournal.com/ https://cdrjournal.com/

ZHANG K X , YANG X H , ZHENG M Y , et al . Acetylated-PPARγ expression is regulated by different p 53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells [J ] . Cancer Biol Med , 2023 , 20 ( 1 ): 56 - 76 . DOI: 10.20892/j.issn.2095-3941.2022.0432 http://doi.org/10.20892/j.issn.2095-3941.2022.0432 https://www.cancerbiomed.org/content/20/1/56 https://www.cancerbiomed.org/content/20/1/56

LI W , KOU J J , ZHANG Z X , et al . Cellular redox homeostasis maintained by malic enzyme 2 is essential for MYC-driven T cell lymphomagenesis [J ] . Proc Natl Acad Sci U S A , 2023 , 120 ( 23 ): e2217 869120.

MOON S H , HUANG C H , HOULIHAN S L , et al . p 53 represses the mevalonate pathway to mediate tumor suppression [J ] . Cell , 2019 , 176 ( 3 ): 564 - 580 .e19. DOI: 10.1016/j.cell.2018.11.011 http://doi.org/10.1016/j.cell.2018.11.011 https://linkinghub.elsevier.com/retrieve/pii/S0092867418315034 https://linkinghub.elsevier.com/retrieve/pii/S0092867418315034

ZHANG Y H , MOHIBI S , VASILATIS D M , et al . Ferredoxin reductase and p 53 are necessary for lipid homeostasis and tumor suppression through the ABCA1-SREBP pathway [J ] . Oncogene , 2022 , 41 ( 12 ): 1718 - 1726 . DOI: 10.1038/s41388-021-02100-0 http://doi.org/10.1038/s41388-021-02100-0

GÓMEZ-SANTOS B , SAENZ DE URTURI D , NUÑEZ-GARCÍA M , et al . Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease [J ] . Aging Cell , 2020 , 19 ( 8 ): e13183 . DOI: 10.1111/acel.v19.8 http://doi.org/10.1111/acel.v19.8 https://onlinelibrary.wiley.com/toc/14749726/19/8 https://onlinelibrary.wiley.com/toc/14749726/19/8

KANG J G , LAGO C U , LEE J E , et al . A mouse homolog of a human TP 53 germline mutation reveals a lipolytic activity of p53 [J ] . Cell Rep , 2020 , 30 ( 3 ): 783 - 792 .e5. DOI: 10.1016/j.celrep.2019.12.074 http://doi.org/10.1016/j.celrep.2019.12.074 https://linkinghub.elsevier.com/retrieve/pii/S2211124719317395 https://linkinghub.elsevier.com/retrieve/pii/S2211124719317395

WANG C Y , WANG C H , MAI R T , et al . Mutant p 53-microRNA-200c-ZEB2-axis-induced CPT1C elevation contributes to metabolic reprogramming and tumor progression in basal-like breast cancers [J ] . Front Oncol , 2022 , 12 : 940402 . DOI: 10.3389/fonc.2022.940402 http://doi.org/10.3389/fonc.2022.940402 https://www.frontiersin.org/articles/10.3389/fonc.2022.940402/full https://www.frontiersin.org/articles/10.3389/fonc.2022.940402/full

XU R , WANG W N , ZHANG W L . Ferroptosis and the bidirectional regulatory factor p 53 [J ] . Cell Death Discov , 2023 , 9 ( 1 ): 197 . DOI: 10.1038/s41420-023-01517-8 http://doi.org/10.1038/s41420-023-01517-8

KUO H C , LUO L X , MA Y , et al . The p53 transactivation domain 1-dependent response to acute DNA damage in endothelial cells protects against radiation-induced cardiac injury [J ] . Radiat Res , 2022 , 198 ( 2 ): 145 - 153 .

THIBAULT B , RAMOS-DELGADO F , GUILLERMET-GUIBERT J . Targeting class Ⅰ-Ⅱ-Ⅲ PI3Ks in cancer therapy: recent advances in tumor biology and preclinical research [J ] . Cancers (Basel) , 2023 , 15 ( 3 ): 784 . DOI: 10.3390/cancers15030784 http://doi.org/10.3390/cancers15030784 https://www.mdpi.com/2072-6694/15/3/784 https://www.mdpi.com/2072-6694/15/3/784

GAO Y Q , JIAO Y T , GONG X Y , et al . Role of transcription factors in apoptotic cells clearance [J ] . Front Cell Dev Biol , 2023 , 11 : 111 0225.

JIAO Z , PAN Y , CHEN F . The metabolic landscape of breast cancer and its therapeutic implications [J ] . Mol Diagn Ther , 2023 , 27 ( 3 ): 349 - 369 . DOI: 10.1007/s40291-023-00645-2 http://doi.org/10.1007/s40291-023-00645-2

CHEN M , CHEN Y . Bioinformatics analysis of common genetic and molecular traits and association of portal hypertension with pulmonary hypertension [J ] . J Healthc Eng , 2022 , 2022 : 9237701 .

RYBICKA M , VERRIER E R , BAUMERT T F , et al . Polymorphisms within DIO 2 and GADD 45 A genes increase the risk of liver disease progression in chronic hepatitis b carriers [J ] . Sci Rep , 2023 , 13 ( 1 ): 6124 . DOI: 10.1038/s41598-023-32753-8 http://doi.org/10.1038/s41598-023-32753-8

YAO P B , ZHANG Z X , LIU H C , et al . P53 protects against alcoholic fatty liver disease via ALDH2 inhibition [J ] . EMBO J , 2023 , 42 ( 8 ): e112304 . DOI: 10.15252/embj.2022112304 http://doi.org/10.15252/embj.2022112304 https://www.embopress.org/doi/10.15252/embj.2022112304 https://www.embopress.org/doi/10.15252/embj.2022112304

XU L , CHEN Z J , ZHANG Y , et al . P53 maintains gallid alpha herpesvirus 1 replication by direct regulation of nucleotide metabolism and ATP synthesis through its target genes [J ] . Front Microbiol , 2022 , 13 : 1044141 . DOI: 10.3389/fmicb.2022.1044141 http://doi.org/10.3389/fmicb.2022.1044141 https://www.frontiersin.org/articles/10.3389/fmicb.2022.1044141/full https://www.frontiersin.org/articles/10.3389/fmicb.2022.1044141/full

CHEN S M , DUAN Y M , WU Y H , et al . A novel integrated metabolism-immunity gene expression model predicts the prognosis of lung adenocarcinoma patients [J ] . Front Pharmacol , 2021 , 12 : 728368 . DOI: 10.3389/fphar.2021.728368 http://doi.org/10.3389/fphar.2021.728368 https://www.frontiersin.org/articles/10.3389/fphar.2021.728368/full https://www.frontiersin.org/articles/10.3389/fphar.2021.728368/full

KEALEY J , DÜSSMANN H , LLORENTE-FOLCH I , et al . Effect of TP 53 deficiency and KRAS signaling on the bioenergetics of colon cancer cells in res ponse to different substrates: a single cell study [J ] . Front Cell Dev Biol , 2022 , 10 : 893677 . DOI: 10.3389/fcell.2022.893677 http://doi.org/10.3389/fcell.2022.893677 https://www.frontiersin.org/articles/10.3389/fcell.2022.893677/full https://www.frontiersin.org/articles/10.3389/fcell.2022.893677/full

JACOBERGER-FOISSAC C , COUSINEAU I , BARECHE Y , et al . CD73 inhibits cGAS-STING and cooperates with CD39 to promote pancreatic cancer [J ] . Cancer Immunol Res , 2023 , 11 ( 1 ): 56 - 71 . DOI: 10.1158/2326-6066.CIR-22-0260 http://doi.org/10.1158/2326-6066.CIR-22-0260 https://aacrjournals.org/cancerimmunolres/article/11/1/56/711811/CD73-Inhibits-cGAS-STING-and-Cooperates-with-CD39 https://aacrjournals.org/cancerimmunolres/article/11/1/56/711811/CD73-Inhibits-cGAS-STING-and-Cooperates-with-CD39

RATHER G M , PRAMONO A A , SZEKELY Z , et al . In cancer, all roads lead to NADPH [J ] . Pharmacol Ther , 2021 , 226 : 107864 . DOI: 10.1016/j.pharmthera.2021.107864 http://doi.org/10.1016/j.pharmthera.2021.107864 https://linkinghub.elsevier.com/retrieve/pii/S0163725821000668 https://linkinghub.elsevier.com/retrieve/pii/S0163725821000668

MIKI K , YAGI M , NOGUCHI N , et al . Induction of glioblastoma cell ferroptosis using combined treatment with chloramphenicol and 2-deoxy-D-glucose [J ] . Sci Rep , 2023 , 13 ( 1 ): 10497 . DOI: 10.1038/s41598-023-37483-5 http://doi.org/10.1038/s41598-023-37483-5

WANG K , LUO L , FU S Y , et al . PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma [J ] . Nat Commun , 2023 , 14 ( 1 ): 1011 . DOI: 10.1038/s41467-023-36708-5 http://doi.org/10.1038/s41467-023-36708-5

SHI T Z , YUAN Z H , HE Y Y , et al . Competition between p53 and YY1 determines PHGDH expression and malignancy in bladder cancer [J ] . Cell Oncol (Dordr) , 2023 : 46 ( 5 ): 1457 - 1472 .

SONG X M , CHEN Q , WANG J F , et al . Cl inical and prognostic implications of an immune-related risk model based on TP 53 status in lung adenocarcinoma [J ] . J Cell Mol Med , 2022 , 26 ( 2 ): 436 - 448 . DOI: 10.1111/jcmm.v26.2 http://doi.org/10.1111/jcmm.v26.2 https://onlinelibrary.wiley.com/toc/15824934/26/2 https://onlinelibrary.wiley.com/toc/15824934/26/2

ZAVILEYSKIY L , BUNIK V . Regulation of p 53 function by formation of non-nuclear heterologous protein complexes [J ] . Biomolecules , 2022 , 12 ( 2 ): 327 . DOI: 10.3390/biom12020327 http://doi.org/10.3390/biom12020327 https://www.mdpi.com/2218-273X/12/2/327 https://www.mdpi.com/2218-273X/12/2/327

INDEGLIA A , LEUNG J C , MILLER S A , et al . An African-specific variant of TP 53 reveals PADI4 as a regulator of p53-mediated tumor suppression [J ] . Cancer Discov , 2023 , 13 ( 7 ): 1696 - 1719 . DOI: 10.1158/2159-8290.CD-22-1315 http://doi.org/10.1158/2159-8290.CD-22-1315 https://aacrjournals.org/cancerdiscovery/article/13/7/1696/727617/An-African-Specific-Variant-of-TP53-Reveals-PADI4 https://aacrjournals.org/cancerdiscovery/article/13/7/1696/727617/An-African-Specific-Variant-of-TP53-Reveals-PADI4

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