谷氨酰胺代谢相关蛋白在肿瘤转移中的作用研究进展

刘雪柔; 杨玉梅; 赵倩; 荣翔宇; 刘伟; 郑瑞洁; 庞金龙; 李娴; 李姗姗

doi:10.19401/j.cnki.1007-3639.2024.01.007

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谷氨酰胺代谢相关蛋白在肿瘤转移中的作用研究进展

综述 | 更新时间：2025-12-31

- 谷氨酰胺代谢相关蛋白在肿瘤转移中的作用研究进展
- Research progress on the role of glutamine metabolism-related proteins in tumor metastasis
- 中国癌症杂志 2024年34卷第1期页码：97-103
- 作者机构：
  
  1. 蚌埠医科大学药学院，安徽蚌埠 233030
  2. 安徽省生化药物工程技术研究中心，安徽蚌埠 233030
- 作者简介：
  
  [ "刘雪柔（ORCID: 0009-0004-2260-8153），硕士。" ]
  李姗姗（ORCID: 0000-0003-2201-6321），博士，副教授、硕士研究生导师。
- 基金信息：
  
  安徽省重点研究与开发计划项目(202104g01020017);安徽省重点生化工程中心科研平台开放课题(2023SYKFD05);安徽省自然科学基金(1908085QH373);国家级大学生创新创业训练计划项目(202210367064);安徽高校自然科学研究项目(KJ2021A0702)
- DOI：10.19401/j.cnki.1007-3639.2024.01.007
  中图分类号： R73-37
- 收稿：2023-10-26，
  
  修回：2023-12-20，
  
  纸质出版：2024-01-30
- 稿件说明：
移动端阅览
刘雪柔, 杨玉梅, 赵倩, 等. 谷氨酰胺代谢相关蛋白在肿瘤转移中的作用研究进展[J]. 中国癌症杂志, 2024,34(1):97-103.

Xuerou LIU, Yumei YANG, Qian ZHAO, et al. Research progress on the role of glutamine metabolism-related proteins in tumor metastasis[J]. China Oncology, 2024, 34(1): 97-103.
刘雪柔, 杨玉梅, 赵倩, 等. 谷氨酰胺代谢相关蛋白在肿瘤转移中的作用研究进展[J]. 中国癌症杂志, 2024,34(1):97-103. DOI： 10.19401/j.cnki.1007-3639.2024.01.007.

Xuerou LIU, Yumei YANG, Qian ZHAO, et al. Research progress on the role of glutamine metabolism-related proteins in tumor metastasis[J]. China Oncology, 2024, 34(1): 97-103. DOI： 10.19401/j.cnki.1007-3639.2024.01.007.

摘要

肿瘤转移是导致癌症患者高死亡率的主要原因。谷氨酰胺在肿瘤的恶性进展中发挥重要作用，近年来研究发现，谷氨酰胺与肿瘤转移密切相关，谷氨酰胺作为肿瘤细胞重要的碳源和氮源，不仅影响肿瘤细胞的增殖，还参与调控肿瘤细胞的迁移和侵袭。此外，谷氨酰胺代谢过程中的各种酶及转运体通过不同的信号转导通路参与肿瘤转移过程。本文综述近年来谷氨酰胺在肿瘤转移中作用的研究进展，并梳理有关治疗靶点，以期为临床治疗肿瘤转移提供新的策略。

Abstract

Tumor metastasis is closely related to high mortality rate of cancer. It is well known that glutamine plays an important role in the malignant progression of cancer. Notably

as an important carbon and nitrogen donor

glutamine has been found to be closely related to tumor metastasis in recent years. Glutamine is not only involved in regulating the proliferation of tumor cells

but is also closely related to the migration and invasion of tumor cells. Furthermore

various enzymes along with transporters in the metabolism of glutamine are involved in the process of tumor metastasis through different signaling pathways. This review provided a summary of the role of glutamine in tumor metastasis in recent years and proposed therapeutic targets to provide new strategies for the clinical treatment of tumor metastases.

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Keywords

references

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