2023年中国乳腺癌重要临床研究成果及最新进展

张琪; 修秉虬; 吴炅

doi:10.19401/j.cnki.1007-3639.2024.02.001

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2023年中国乳腺癌重要临床研究成果及最新进展

专家述评 | 更新时间：2025-12-31

- 2023年中国乳腺癌重要临床研究成果及最新进展
- Progress of important clinical research of breast cancer in China in 2023
- 中国癌症杂志 2024年34卷第2期页码：135-142
- 作者机构：
  
  1. 复旦大学附属肿瘤医院乳腺外科，复旦大学上海医学院肿瘤学系，上海 200032
  2. 中国上海肿瘤医学协同创新中心，上海 200032
- 作者简介：
  
  [ "张琪（ORCID: 0000-0003-0876-7495），博士，复旦大学附属肿瘤医院博士后" ]
  [ "吴炅，主任医师，教授，博士研究生导师，复旦大学附属肿瘤医院副院长，药物临床试验机构主任。学术任职包括：中国抗癌协会乳腺癌专业委员会主任委员，中国医师协会外科医师分会乳腺外科医师专业委员会副主任委员，中国医师协会肿瘤医师分会副主任委员，中华医学会肿瘤学分会常委，中华医学会外科分会乳腺外科学组副组长，上海市医学会肿瘤专科分会候任主任委员，上海市抗癌协会乳腺癌专业委员会荣誉主任委员，上海市医学会肿瘤靶分子专科分会前任主任委员。擅长乳腺癌的综合治疗，特别是新的外科诊疗技术在乳腺疾病中的应用，包括乳腺癌保乳手术、乳腺癌前哨淋巴结活检、乳腺癌即刻乳房重建手术。主持编撰了《乳腺肿瘤整形与乳房重建专家共识（2018年版）》、《保留乳房治疗专家共识（2020年版）》和《乳腺肿瘤整形与乳房重建专家共识（2022年版）》，并连续14年主办上海市乳房重建论坛。以第一作者及通讯作者在SCI收录期刊上发表论文100余篇。主编《乳腺癌术后乳房重建》、《乳腺癌的乳房重建手术》、Reconstruction Surgery in Breast Cancer，参编《现代乳腺肿瘤学进展》、《肿瘤外科手术学》、《乳腺肿瘤学》等专著。曾被授予上海市卫生局首批“医苑新星”、上海市卫生局先进工作者、复旦大学“世纪之星”，获得上海市科技启明星、上海市教委曙光计划、上海市科学技术委员会优秀学术带头人计划等人才基金。目前承担国家重大慢病非传染性疾病防控研究课题及国家自然科学基金面上项目等。2004年以第三完成人获国家科技进步二等奖（乳腺癌的临床和基础研究），并多次以主要完成人获得多项上海市科技进步奖；以第一完成人获得上海市临床医学成果奖。" ]
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2024.02.001
  中图分类号： R737.9
- 收稿：2024-01-16，
  
  修回：2024-01-30，
  
  纸质出版：2024-02-29
- 稿件说明：
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张琪, 修秉虬, 吴炅. 2023年中国乳腺癌重要临床研究成果及最新进展[J]. 中国癌症杂志, 2024,34(2):135-142.

Qi ZHANG, Bingqiu XIU, Jiong WU. Progress of important clinical research of breast cancer in China in 2023[J]. China Oncology, 2024, 34(2): 135-142.
张琪, 修秉虬, 吴炅. 2023年中国乳腺癌重要临床研究成果及最新进展[J]. 中国癌症杂志, 2024,34(2):135-142. DOI： 10.19401/j.cnki.1007-3639.2024.02.001.

Qi ZHANG, Bingqiu XIU, Jiong WU. Progress of important clinical research of breast cancer in China in 2023[J]. China Oncology, 2024, 34(2): 135-142. DOI： 10.19401/j.cnki.1007-3639.2024.02.001.

摘要

乳腺癌是全球女性发病率最高的恶性肿瘤，严重威胁女性健康。随着乳腺癌分期分型诊治原则的确立和新型抗肿瘤药物的研发与应用，乳腺癌患者的生存情况和生活质量不断得到改善。中国乳腺癌患者基数大，具有独特的发病特征，需要不断探索更合适的治疗策略；临床研究的体量和水平也在不断提升。2023年，针对不同亚型乳腺癌均有重要的临床研究成果。在外科治疗方面，关于靶向腋窝淋巴结清扫的临床试验和对侧乳腺癌风险预测

BRCA

-CRisk模型的建立为外科降阶梯治疗提供了更多的证据；在人表皮生长因子受体2（human epidermal growth factor receptor 2，HER2）阳性乳腺癌方面，吡咯替尼在晚期乳腺癌治疗中显示出明显疗效；在三阴性乳腺癌方面，精准分型治疗和免疫治疗持续改善患者的生存情况；在激素受体阳性乳腺癌方面，对低风险患者豁免化疗以及探索内分泌治疗耐药后的可选方案均有重要研究成果；在

BRCA

突变方面，BGB-290-201临床研究进一步确认了多腺苷二磷酸核糖聚合酶[poly(ADP-ribose) polymerase，PARP

]

抑制剂用于中国人群的治疗效果和安全性，对晚期HER2阴性携带

BRCA

胚系（germline

BRCA

，g

BRCA

）1/2突变的乳腺癌患者，帕米帕利将会是一个理想的治疗选择。本文对2023年中国乳腺癌领域的重要临床研究进行回顾，总结关键结果，以期为未来的临床研究提供参考。

Abstract

Breast cancer is the most prevalent malignant tumor among women globally

posing a serious threat to women's health. With the establishment of staging and typing principles for breast cancer diagnosis and treatment

and the development and application of novel antitumor drugs

the survival and quality of life of breast cancer patients have been continuously improving. In China

the large base of breast ca

ncer patients possesses unique incidence characteristics

necessitating ongoing exploration of more appropriate treatment strategies; the volume and level of clinical research are also continuously advancing. In 2023

significant clinical research results were reported for different subtypes of breast cancer. In surgical treatment

clinical trials on targeted axillary lymph node dissection and the establishment of a predictive model

BRCA

-CRisk for contralateral breast cancer risk provide more evidence for de-escalation in surgical treatment. In the area of human epidermal growth factor receptor 2 (HER2)-positive breast cancer

pyrotinib has shown significant efficacy in advanced breast cancer treatment. In triple-negative breast cancer

precision subtype treatment and immunotherapy continue to improve patient survival. For hormone receptor-positive breast cancer

significant research results were obtained in exempting low-risk patients from chemotherapy and exploring alternative options after resistance to endocrine therapy. In the aspect of

BRCA

mutations

BGB-290-201 further confirmed the therapeutic efficacy and safety of poly(ADP-ribose) polymerase (PARP) inhibitors for the Chinese population. For advanced HER2-negative patients carrying germline

BRCA

)1/2 mutations

pamiparib will be an ideal treatment choice. This article reviews the important clinical research in the field of breast cancer in China in 2023

summarizes key results

and aims to provide reference ideas for future clinical research.

关键词

Keywords

references

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邵志博 , 杨犇龙 , 吴炅 . 2022年中国乳腺癌重要临床试验成果及最新进展 [J ] . 中国癌症杂志 , 2023 , 33 ( 2 ): 103 - 109 . DOI: 10.19401/j.cnki.1007-3639.2023.02.002 http://doi.org/10.19401/j.cnki.1007-3639.2023.02.002

SHAO Zhibo , YANG Benlong , WU Jiong . Progress of important clinical trials of breast cancer in China in 2022 [J ] . China Oncology , 2023 , 33 ( 2 ): 103 - 109 . DOI: 10.19401/j.cnki.1007-3639.2023.02.002 http://doi.org/10.19401/j.cnki.1007-3639.2023.02.002

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